UNASSIGNED:多项研究探索了使用视觉皮层非侵入性脑刺激(NIBS)增强视觉功能的方法。这些研究的样本量各不相同,结果衡量标准,和方法论。我们进行了系统评价和荟萃分析,以评估NIBS对视力正常的人类参与者的视觉功能的影响。
未经批准:我们遵循了PRISMA指南,并且在研究开始前在PROSPERO注册了审查方案(CRD42021255882)。我们搜查了Embase,Medline,PsychInfo,PubMed,OpenGrey和WebofScience使用相关关键字。搜索时间为2000年1月1日至2021年9月1日。采用综合荟萃分析(CMA)软件进行定量分析。
UNASSIGNED:50项研究纳入系统评价。只有5项研究使用经颅磁刺激(TMS),没有TMS研究符合我们预先指定的荟萃分析标准。19项经颅电刺激研究(tES,38%)符合荟萃分析的标准,是我们综述的重点。Meta分析显示tES对对比敏感度的急性效应(Hedges\sg=0.232,95%CI:0.023-0.442,p=0.029)和后效应(0.590,95%CI:0.182-0.998,p=0.005)。视觉诱发电位(VEP)振幅在tES后立即显着增强(0.383,95%CI:0.110-0.665,p=0.006)。tES(0.563,95%CI:0.230-0.896,p=0.001)和单独的经颅直流电刺激(a-tDCS)(0.655,95%CI:0.273-1.038,p=0.001)均可减少周边视觉中的拥挤。tES对视力的影响,运动知觉和反应时间无统计学意义。
UNASSIGNED:视觉皮层tES对对比敏感度有显著影响,VEP振幅,皮质兴奋性指数,在正常视力的个体中拥挤。需要其他研究才能对TMS效应进行可比的荟萃分析。未来的研究需要进行稳健的实验设计,以将这些发现扩展到视力丧失的人群。
未经评估:ClinicalTrials.gov/,标识符CRD42021255882。
UNASSIGNED: Multiple studies have explored the use of visual cortex non-invasive brain stimulation (NIBS) to enhance visual function. These studies vary in sample size, outcome measures, and methodology. We conducted a systematic
review and meta-analyses to assess the effects of NIBS on visual functions in human participants with normal vision.
UNASSIGNED: We followed the PRISMA guidelines, and a
review protocol was registered with PROSPERO before study commencement (CRD42021255882). We searched Embase, Medline, PsychInfo, PubMed, OpenGrey and Web of Science using relevant keywords. The search covered the period from 1st January 2000 until 1st September 2021. Comprehensive meta-analysis (CMA) software was used for quantitative analysis.
UNASSIGNED: Fifty studies were included in the systematic
review. Only five studies utilized transcranial magnetic stimulation (TMS) and no TMS studies met our pre-specified criteria for meta-analysis. Nineteen transcranial electrical stimulation studies (tES, 38%) met the criteria for meta-analysis and were the focus of our
review. Meta-analysis indicated acute effects (Hedges\'s g = 0.232, 95% CI: 0.023-0.442, p = 0.029) and aftereffects (0.590, 95% CI: 0.182-0.998, p = 0.005) of tES on contrast sensitivity. Visual evoked potential (VEP) amplitudes were significantly enhanced immediately after tES (0.383, 95% CI: 0.110-0.665, p = 0.006). Both tES (0.563, 95% CI: 0.230-0.896, p = 0.001) and anodal-transcranial direct current stimulation (a-tDCS) alone (0.655, 95% CI: 0.273-1.038, p = 0.001) reduced crowding in peripheral vision. The effects of tES on visual acuity, motion perception and reaction time were not statistically significant.
UNASSIGNED: There are significant effects of visual cortex tES on contrast sensitivity, VEP amplitude, an index of cortical excitability, and crowding among normally sighted individuals. Additional studies are required to enable a comparable meta-analysis of TMS effects. Future studies with robust experimental designs are needed to extend these findings to populations with vision loss.
UNASSIGNED: ClinicalTrials.gov/, identifier CRD42021255882.