登革热病毒是属于黄病毒科的虫媒病毒,其临床表现范围从无症状到极端条件(登革热出血热/登革热休克综合征)。对这种疾病已经做了很多研究,然而,这种疾病没有有效的治疗方法。这篇综述提供了对所有登革热蛋白的系统理解,其结构蛋白的作用(C蛋白,E蛋白,PRM)在病毒进入中,装配,以及在宿主细胞中的分泌,和非结构蛋白(NS1,NS2a,NS2b,NS3、NS4a、NS4b,和NS5)在病毒组装中,复制,登革热进展过程中的免疫逃避和发病机制。此外,该评论强调了与唯一市售登革热疫苗有关的争议,也就是说,Dengvaxia,以及与之相关的风险。最后,它提供了有关开发有效的抗登革热治疗的各种方法的见解。
Dengue virus is an arbovirus belonging to class Flaviviridae Its clinical manifestation ranges from asymptomatic to extreme conditions (dengue hemorrhagic fever/dengue shock syndrome). A lot of research has been done on this ailment, yet there is no effective treatment available for the disease. This
review provides the systematic understanding of all dengue proteins, role of its structural proteins (C-protein, E-protein, prM) in virus entry, assembly, and secretion in host cell, and nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5) in viral assembly, replication, and immune evasion during dengue progression and pathogenesis. Furthermore, the
review has highlighted the controversies related to the only commercially available dengue vaccine, that is, Dengvaxia, and the risk associated with it. Lastly, it provides an insight regarding various approaches for developing an effective anti-dengue treatment.