Abstract：
African swine fever virus (ASFV) has been traditionally a major animal health problem worldwide, with important economic impact for the pig industry. Recently the disease has re-emerged in large areas of the world, including China and Eastern Europe. Therefore, it seems timely to summarize our current understanding of ASFV proteins and their antigenic properties, in connection with potential vaccine formulations. Here we review the main characteristics of the major structural proteins p150, p72 and p17 of ASFV and their antigenic properties. In particular, we emphasize that p17 was detected as a specific antigen in the immunoreaction of pig sera with neutralizing antibodies. In addition, specific immunoreactions against IP97, IP27, IP25.5, IP23 and IP13 viral infection proteins were also detected in these sera. The viral structural proteins have been studied with intracellular and extracellular viruses and, therefore the differences between both classes of viruses were also reviewed.
摘要：
非洲猪瘟病毒（ASFV）一直是世界范围内的主要动物健康问题，对养猪业具有重要的经济影响。最近，这种疾病在世界大片地区重新出现，包括中国和东欧。因此,总结我们目前对ASFV蛋白及其抗原特性的理解似乎是及时的，与潜在的疫苗配方有关。在这里，我们回顾了ASFV的主要结构蛋白p150，p72和p17的主要特征及其抗原特性。特别是,我们强调，在猪血清与中和抗体的免疫反应中，p17被检测为特异性抗原。此外,在这些血清中还检测到针对IP97，IP27，IP25.5，IP23和IP13病毒感染蛋白的特异性免疫反应。病毒结构蛋白已经研究了细胞内和细胞外病毒，因此，还审查了两类病毒之间的差异。
