■原发性阴道癌是一种罕见的疾病。一些研究表明,在因癌前和恶性宫颈疾病而接受子宫切除术的患者中,阴道癌的风险增加。然而,关于良性子宫切除术后原发性阴道癌的文献有限.
■这篇综述旨在调查有关临床特征的现有证据,治疗,良性疾病子宫切除术后原发性阴道癌的结局。此外,我们提供一例因异常子宫出血而接受子宫切除术10年后发生原发性阴道癌的患者.
■我们对PubMed进行了全面的文献检索,Scopus,WebofScience使用标题和摘要的组合,以“子宫切除术”为代表,和“阴道癌”;“阴道肿瘤”;和“阴道癌”。未应用文章类型限制。
■本综述纳入8项研究,共56例。观察到的主要症状是阴道出血。鳞状细胞癌是最常见的类型,其次是腺癌。大多数阴道癌病例发生在子宫切除术后约10年。肿瘤最常见的位置是在阴道尖部。管理方法各不相同,有25个案例提供了详细信息。其中,7例单纯放疗,1例同步放化疗,其余病例接受手术作为主要治疗,有或没有额外的辅助治疗。15例患者有随访数据,2例死亡,2例复发。在考虑随访时,其他病例还活着并且很好。
■子宫切除术后的原发性阴道癌是一种极其罕见的疾病。必须有高水平的证据来指导这种罕见疾病的筛查和治疗策略。一部分因良性疾病而接受子宫切除术的妇女可以从阴道细胞学评估中受益。手术后推迟初始筛查并延长后续筛查之间的间隔是合理的。进一步的回顾性病例对照试验有望确定上述患者的哪些特定亚组可能最有可能从筛查中受益。子宫切除术后阴道癌的治疗决策更有利于基于放疗的管理而不是手术。阴道子宫内膜样腺癌可能起因于子宫内膜异位症的恶性转化。预计更多的研究将探讨这两种疾病之间的相关性。
UNASSIGNED: Primary vaginal cancer is a rare condition. Some studies have revealed an increased risk of vaginal cancer among patients who have undergone hysterectomy for premalignant and malignant cervical disease. However, there is limited literature available on primary vaginal cancer following hysterectomy for benign conditions.
UNASSIGNED: This
review aimed to investigate available evidence on clinical characteristics, treatments, and outcomes of primary vaginal cancer following hysterectomy for benign diseases. Additionally, we provide a case of a patient who developed primary vaginal cancer 10 years after undergoing hysterectomy for abnormal uterine bleeding.
UNASSIGNED: We conducted a comprehensive literature search on PubMed, Scopus, Web of Science using a combination of title and abstract represented by \"hysterectomy\", and \"vaginal cancer\"; \"vaginal neoplasm\"; and \"cancer of vagina\". No article type restrictions were applied.
UNASSIGNED: Eight studies with a total of 56 cases were included in this
review. The main symptom observed was vaginal bleeding. Squamous cancer was found to be the most common type, followed by adenocarcinoma. The majority of vaginal cancer cases occurred approximately 10 years after undergoing hysterectomy. The most common location of the tumor was in the vaginal apex. The management approaches varied and details were available in 25 cases. Among these, 7 cases were treated with radiotherapy alone, 1 case received concurrent chemoradiation therapy, and the of rest of the cases underwent surgery as the primary treatment, with or without additional adjuvant therapy. Data of follow-up was available for 15 cases, with 2 cases resulting in death and 2 cases experiencing recurrence. The other cases were alive and well at the time of considered follow up.
UNASSIGNED: Primary vaginal cancer after hysterectomy for benign conditions is an extremely rare condition. It is essential to have high-level evidence to guide the screening and treatment strategy for this rare condition. A part of women who have undergone hysterectomy for benign disorders can benefit from vaginal cytology evaluation. It is reasonable to postpone the initial screening after surgery and to extend the interval between subsequent screenings. Further retrospective case-control trials are expected to determine which specific subgroups of patients mentioned above might most potentially benefit from screening. The treatment decision for vaginal cancer after hysterectomy is more favorable to radiotherapy-based management rather than surgery. Vaginal endometrioid adenocarcinoma may arise from the malignant transformation of endometriosis. More studies are expected to investigate the correlation between these two diseases.