Urology

泌尿外科
  • 文章类型: Journal Article
    背景:这项研究旨在实施一套可穿戴技术,以记录和分析外科医生在进行常规和机器人辅助腹腔镜手术期间的生理和人体工程学参数,比较外科手术过程中外科医生的人体工程学和压力水平。
    方法:本研究以两种不同的设置进行组织:模拟器任务和实验模型外科手术。参与的外科医生以随机方式在腹腔镜和机器人辅助手术中执行任务和外科手术。不同的可穿戴技术被用来记录外科医生的姿势,肌肉活动,手术期间的皮肤电活动和心电图信号。
    结果:模拟器研究涉及6名外科医生:3名经验丰富(>100例腹腔镜手术;36.33±13.65岁)和3名新手(<100例腹腔镜手术;29.33±8.39岁)。3名具有腹腔镜手术经验的不同外科专业的外科医生(>100例腹腔镜手术;37.00±5.29岁),但是没有手术机器人的经验,参加了实验模型研究。参与的外科医生在机器人辅助外科手术期间显示出增加的压力水平。总的来说,在机器人辅助手术中获得了改善的外科医生姿势,减少局部肌肉疲劳。
    结论:实施了一套可穿戴技术来测量和分析外科医生的生理和人体工程学参数。与传统的腹腔镜手术相比,机器人辅助手术对外科医生显示出更好的人体工程学结果。人体工程学分析使我们能够优化外科医生的表现并改善手术训练。
    BACKGROUND: This study aims to implement a set of wearable technologies to record and analyze the surgeon\'s physiological and ergonomic parameters during the performance of conventional and robotic-assisted laparoscopic surgery, comparing the ergonomics and stress levels of surgeons during surgical procedures.
    METHODS: This study was organized in two different settings: simulator tasks and experimental model surgical procedures. The participating surgeons performed the tasks and surgical procedures in both laparoscopic and robotic-assisted surgery in a randomized fashion. Different wearable technologies were used to record the surgeons\' posture, muscle activity, electrodermal activity and electrocardiography signal during the surgical practice.
    RESULTS: The simulator study involved six surgeons: three experienced (>100 laparoscopic procedures performed; 36.33 ± 13.65 years old) and three novices (<100 laparoscopic procedures; 29.33 ± 8.39 years old). Three surgeons of different surgical specialties with experience in laparoscopic surgery (>100 laparoscopic procedures performed; 37.00 ± 5.29 years old), but without experience in surgical robotics, participated in the experimental model study. The participating surgeons showed an increased level of stress during the robotic-assisted surgical procedures. Overall, improved surgeon posture was obtained during robotic-assisted surgery, with a reduction in localized muscle fatigue.
    CONCLUSIONS: A set of wearable technologies was implemented to measure and analyze surgeon physiological and ergonomic parameters. Robotic-assisted procedures showed better ergonomic outcomes for the surgeon compared to conventional laparoscopic surgery. Ergonomic analysis allows us to optimize surgeon performance and improve surgical training.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    背景:留置导尿管通常会导致并发症,例如有症状的尿路感染。在养老院的居民中,导管患病率很高,但是社会人口统计学特征的患病率差异,合并症,和卫生服务的使用很少被调查。这项工作的目的是描述在养老院居民中留置导尿管的使用,并检查导尿管的使用是否与个体特征有关。
    方法:分析了2014年10月至2015年4月期间在21家德国疗养院进行的“疗养院中使用不适当药物治疗”(IMREN)研究的横断面数据。对于所有相关护理单位的居民,参与机构的护士完成了包括改良Rankin量表在内的匿名问卷,以评估身体损伤.确定养老院居民留置导尿管的比例。通过聚类调整多变量逻辑回归研究导管使用与个体特征之间的关联。
    结果:在852名居民中(76.5%为女性;平均年龄83.5岁),13.4%有留置导尿管。男性使用导管的调整后优势比与女性为2.86(95%置信区间1.82-4.50).对于“中度”残疾的居民与那些“不轻微”残疾的人是3.27(1.36-7.85),对于患有“中度重度”残疾的个人与参照组为9.03(3.40-23.97),对于那些“严重”残疾的人来说参照组为26.73(8.60-83.14)。对于在过去12个月内住院的居民,未住院者为1.97(1.01-3.87)。对于年龄,痴呆症,超重/肥胖,其他留置装置,和长期用药未发现显著关联.
    结论:男性养老院居民,身体损伤程度较高的居民,在过去12个月内住院的患者使用留置导尿管的可能性高于同行.导管的情况和适应症的数据,导管类型,需要导管插入时间和导管插入时间来评估养老院居民使用导管的适当性和干预措施的必要性。
    BACKGROUND: Indwelling urinary catheters often lead to complications such as symptomatic urinary tract infections. In nursing home residents, catheter prevalence is high, but prevalence differences by sociodemographic characteristics, comorbidities, and health services use have rarely been investigated. The purpose of this work was to describe the use of indwelling urinary catheters in nursing home residents and to examine whether catheter use is associated with individual characteristics.
    METHODS: Cross-sectional data of the \"Inappropriate Medication in patients with REnal insufficiency in Nursing homes\" (IMREN) study conducted in 21 German nursing homes between October 2014 and April 2015 were analyzed. For all residents of the involved care units, nurses of the participating institutions completed an anonymous questionnaire including the Modified Rankin Scale to assess physical impairments. The proportion of nursing home residents with indwelling urinary catheter was determined. Associations between catheter use and individual characteristics were investigated via cluster-adjusted multivariable logistic regression.
    RESULTS: Of 852 residents (76.5% female; mean age 83.5 years), 13.4% had an indwelling urinary catheter. The adjusted odds ratios for catheter use for men vs. women was 2.86 (95% confidence interval 1.82-4.50). For residents with \"moderate\" disability vs. those with \"no to slight\" disability it was 3.27 (1.36-7.85), for individuals with \"moderately severe\" disability vs. the reference group it was 9.03 (3.40-23.97), and for those with \"severe\" disability vs. the reference group it was 26.73 (8.60-83.14). For residents who had been hospitalized within the last 12 months vs. those without a hospitalization it was 1.97 (1.01-3.87). For age, dementia, overweight/obesity, other indwelling devices, and long-term medications no significant associations were found.
    CONCLUSIONS: Male nursing home residents, residents with a higher degree of physical impairment, and those who had been hospitalized within the last 12 months were more likely to use an indwelling urinary catheter than their counterparts. Data on circumstances of and indications for catheters, catheter types, and duration of catheterization are needed to evaluate the appropriateness of catheter use in nursing home residents and the need for interventions.
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  • 文章类型: Journal Article
    膀胱保留方法适用于不愿意或不适合行根治性膀胱切除术(RC)的患者。文献中关于这两种方法的生存率比较存在不一致之处。我们的目标是评估接受不同治疗方法的肌肉浸润性膀胱癌(MIBC)患者的生存率。
    回顾性横断面研究。
    二级护理,克尔曼的多中心研究,伊朗2008年至2016年。
    所有200例患者被诊断为肌肉浸润性膀胱癌,并被我们的医院收治。排除了无法获取医疗档案的患者和TCC以外的其他病理患者。
    根据生存率比较了根治性膀胱切除术和不同的膀胱保存方法。
    根治性膀胱切除术或保留膀胱。
    患者的总生存期为2年[95%CI:1.37-2.63]。MIBC患者的5年总生存率为32%。总生存期为6.4年,与其他组相比,RC组的生存率最高(p=0.01);接受TMT的患者的总生存率,TURT,化疗,或放疗单药治疗为3.15年[95%CI:2.242-4.061],4.06[95%CI:3.207-4.931],2.58[95%CI:1.767-3.399],和3.14[95%CI:1.614-4.672]年,分别。65岁以下接受RC的患者的总生存期为7年,与TMT组的2年相比。(p=0.0001)。
    膀胱保存方法,作为RC的替代品,在我们的研究中显示总体生存率较低。前瞻性随机临床试验可能会宣布最佳治疗方法。
    UNASSIGNED: Bladder-Sparing Approach was presented in patients who are not willing or not suitable for Radical Cystectomy (RC). There have been inconsistencies in the literature regarding the comparison of survival rates of these two methods. Our objective is to evaluate the survival rate of patients with muscle-invasive bladder cancer (MIBC) undergoing different treatment methods.
    UNASSIGNED: Retrospective cross-sectional study.
    UNASSIGNED: A secondary care, multicenter study in Kerman, Iran 2008 to 2016.
    UNASSIGNED: All 200 patients who were diagnosed with Muscle Invasive Bladder Cancer and were admitted to our hospitals. Patients with inaccessible medical files and patients with pathologies other than TCC were excluded.
    UNASSIGNED: Radical cystectomy and different methods of bladder preservation were compared based on their survival rate.
    UNASSIGNED: Radical cystectomy or bladder preservation.
    UNASSIGNED: Overall survival of the patients was 2 years [95% CI: 1.37-2.63]. The overall 5-year survival rate of patients with MIBC was 32%. Having a 6.4 years overall survival, the RC group showed the highest survival compared with others (p = 0.01); the overall survival of patients undergoing TMT, TURT, chemotherapy, or radiotherapy monotherapy was 3.15 years [95% CI: 2.242-4.061], 4.06 [95% CI: 3.207-4.931], 2.58 [95% CI: 1.767-3.399], and 3.14 [95% CI: 1.614-4.672] years, respectively. Patients younger than 65 undergoing RC had an overall survival of 7 years, compared with 2 years for the TMT group. (p = 0.0001).
    UNASSIGNED: The Bladder-Preservation method, as a replacement for RC, showed a lower overall survival rate in our study. A prospective randomized clinical trial may declare the best treatment.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    背景:经尿道膀胱肿瘤电切术(TURBT)是泌尿科医师最常见的手术之一。它通常被描述为“无切口”和“耐受性良好”的手术。然而,许多病人经历痛苦和不适的程序。存在改善TURBT体验的大量机会。已开发出由膀胱癌患者及其提供者设计的增强术后恢复(ERAS)方案。
    方法:这是一个单中心,随机对照试验,以研究ERAS方案与常规治疗相比在接受门诊TURBT的膀胱癌患者中的有效性。ERAS协议由术前,术中和术后组件旨在优化围手术期护理的每个阶段。将招募100名年龄≥18岁的疑似或已知膀胱癌患者,接受初次或重复的动态TURBT。恢复质量15分的变化,恢复质量的衡量标准,在手术当天和术后第1天之间,将比较ERAS组和对照组。
    背景:该试验已获得约翰·霍普金斯大学机构审查委员会#00392063的批准。参与者将在参与研究之前提供知情同意书。结果将在单独的出版物中报告。
    背景:NCT05905276。
    BACKGROUND: Transurethral resection of bladder tumour (TURBT) is one of the more common procedures performed by urologists. It is often described as an \'incision-free\' and \'well-tolerated\' operation. However, many patients experience distress and discomfort with the procedure. Substantial opportunity exists to improve the TURBT experience. An enhanced recovery after surgery (ERAS) protocol designed by patients with bladder cancer and their providers has been developed.
    METHODS: This is a single-centre, randomised controlled trial to investigate the effectiveness of an ERAS protocol compared with usual care in patients with bladder cancer undergoing ambulatory TURBT. The ERAS protocol is composed of preoperative, intraoperative and postoperative components designed to optimise each phase of perioperative care. 100 patients with suspected or known bladder cancer aged ≥18 years undergoing initial or repeat ambulatory TURBT will be enrolled. The change in Quality of Recovery 15 score, a measure of the quality of recovery, between the day of surgery and postoperative day 1 will be compared between the ERAS and control groups.
    BACKGROUND: The trial has been approved by the Johns Hopkins Institutional Review Board #00392063. Participants will provide informed consent to participate before taking part in the study. Results will be reported in a separate publication.
    BACKGROUND: NCT05905276.
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  • 文章类型: Journal Article
    简介随着腹腔镜活体肾切除术(LLDN)领域多年来的发展,人们越来越重视优化手术技术和结果,以确保活体肾脏捐献者的安全和健康.对LLDN的早期经验,以挑战和担忧为标志,如开放手术的高转化率和由于技术原因导致的早期移植物丢失,促使对右侧供体肾切除术的方法进行重新评估。在这篇文章中,我们的目标是比较在我们的中心进行的右LLDN和左LLDN的安全性和有效性,并提供有价值的见解,最终可以提高患者的预后并确保活体器官捐献者的健康.方法2018年1月至2022年1月,我们收集了16例右侧LLDN,并与同期在巴林王国和约旦进行的134例左侧LLDN手术进行比较。我们分析了供体年龄的差异,性别,手术时间,热缺血时间(WIT),移植物功能,并发症,并转换为开放技术。从医疗记录和手术数据库中提取患者数据和手术结果。进行统计学分析以确定两组之间的显著差异。使用卡方检验和逻辑回归分析比较了并发症和安全性结果等分类变量。感兴趣的主要结果包括安全性指标,如并发症发生率,血管并发症,移植物丢失,术后血清肌酐水平。结果我们的研究显示两组人口统计学相似。然而,左侧LLDN的手术时间较短,81分钟,而右边为96分钟。热缺血时间(WIT)在左侧4.5分钟和右侧5.2分钟时相当。左侧移植功能延迟的发生率较低(与右侧组相比,左侧组无一例)。两组在血清肌酐水平方面具有相似的六个月移植物功能(左侧为0.98mg/dL,右侧为1.2mg/dL),住院时间(左侧为2.5天,右侧为2.8天),和估计失血量(EBL)(左侧90mL,右侧50mL)。此外,两组均不需要输血,但右侧LLDN组有1例中转开腹手术.结论我们的数据证实了正确的LLDN的安全性和有效性,与目前的文献一致。这增加了支持在指示时在右侧使用腹腔镜取回的累积证据。
    Introduction As the field of laparoscopic living donor nephrectomy (LLDN) has progressed over the years, there has been a growing emphasis on optimizing surgical techniques and outcomes to ensure the safety and well-being of living kidney donors. The early experiences with right LLDN, marked by challenges and concerns such as high conversion rates to open surgery and early graft loss due to technical reasons, prompted a reevaluation of the approach toward right-sided donor nephrectomies. In this article, we aim to compare the safety and efficacy of right LLDN to left LLDN performed in our centers and to provide valuable insights that can ultimately enhance patient outcomes and ensure the well-being of living organ donors. Methods Between January 2018 and January 2022, we conducted 16 cases of right LLDN and compared them with 134 cases of left LLDN procedures done in the Kingdom of Bahrain and Jordan over the same time period. We analyzed differences in donor age, sex, operative time, warm ischemia time (WIT), graft function, complications, and conversion to open technique. Patient data and surgical outcomes were extracted from medical records and surgical databases. Statistical analysis was conducted to identify significant differences between the two groups. Categorical variables such as complications and safety outcomes were compared using chi-square tests and logistic regression analysis. The primary outcomes of interest included safety metrics such as complication rates, vascular complications, graft loss, and postoperative serum creatinine levels for the recipients. Results Our study showed similar demographics in both groups. However, the operative time was shorter for the left LLDN, with 81 minutes compared to 96 minutes for the right. Warm ischemia times (WITs) were comparable at 4.5 minutes for the left and 5.2 minutes for the right. There was less incidence of delayed graft function on the left side (none in the left group compared to one case in the right group). Both groups had similar six-month graft function in terms of serum creatinine levels (0.98 mg/dL for the left and 1.2 mg/dL for the right), hospital stays (2.5 days for the left and 2.8 days for the right), and estimated blood loss (EBL) (90 mL for the left and 50 mL for the right). Additionally, no blood transfusions were required in either group, but there was one case of conversion to open surgery in the right LLDN group. Conclusion Our data confirm the safety and efficacy of the right LLDN, consistent with the current literature. This increases the cumulative evidence supporting the use of laparoscopic retrieval on the right side when indicated.
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  • 文章类型: Journal Article
    睾丸扭转(TT)是一种罕见但紧急的疾病;它导致严重的疼痛和肿胀,必须立即诊断和治疗,预期期为6-8小时。这是到达急诊科的重要预后因素。提高对TT的认识对于确保早期诊断和及时治疗至关重要,可以防止不可逆的损害和生育能力的丧失。
    我们的研究旨在测量意识,知识,沙特阿拉伯普通人群对睾丸扭转(TT)的态度。
    这是一项对居住在沙特阿拉伯的普通人群进行的横断面研究。使用在线调查在人群中分发了一份自我管理的问卷。问卷包括社会人口统计特征(即,年龄,性别,区域,等。),评估睾丸扭转知识的问卷,和调查问卷来评估患病率,管理,以及对睾丸扭转的态度。
    在473名参与者中,56%是男性,61%的人年龄在18至30岁之间。不幸的是,我们四分之一的人口对睾丸扭转有很好的了解。关于睾丸扭转评分的总体平均知识低于平均水平(8分中的3分)。与知识增加相关的因素包括年龄较小,男性,生活在中部地区,在医疗领域工作,听说了睾丸扭转,有睾丸扭转的个人或家族史。
    总而言之,一般人群缺乏睾丸扭转知识。应该进行进一步的研究和社会运动,以鼓励普通人群的理解并提高他们的知识水平。
    UNASSIGNED: Testicular torsion (TT) is a rare but urgent condition; it leads to severe pain and swelling that must be diagnosed and treated immediately, where there is an expectant period of 6-8 h. It is an important prognostic factor in the arrival time to the emergency department. Raising awareness about TT is essential to ensure early diagnosis and timely treatment, which can prevent irreversible damage and loss of fertility.
    UNASSIGNED: Our study aimed to measure the awareness, knowledge, and attitude toward testicular torsion (TT) among the general population in Saudi Arabia.
    UNASSIGNED: This is a cross-sectional study conducted among the general population living in Saudi Arabia. A self-administered questionnaire was distributed among the population using an online survey. The questionnaire includes socio-demographic characteristics (i.e., age, gender, region, etc.), a questionnaire to assess the knowledge of testicular torsion, and questionnaires to assess the prevalence, management, and attitude toward testicular torsion.
    UNASSIGNED: Of the 473 participants, 56% were males, and 61% were aged between 18 to 30 years old. Unfortunately, One quarter of our population has a good knowledge level about testicular torsion. The overall mean knowledge about Testicular Torsion score was below average (3 out of 8 points). Factors associated with increased knowledge include younger age, male gender, living in the Central Region, working in the medical field, having heard of testicular torsion, and having a personal or family history of testicular torsion.
    UNASSIGNED: In conclusion, there was a lack of testicular torsion knowledge among the general population. Further studies and social campaigns should be done to encourage the general population\'s understanding and increase their knowledge level.
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  • 文章类型: Journal Article
    背景:有限的研究探索了药剂师主导的抗菌药物管理计划(ASP)在泌尿科的有效性。
    目的:评估药剂师主导的多方面ASP对抗生素使用和临床结果的影响。
    方法:我们对在广州某大型教学医院泌尿科接受一种或多种抗生素治疗的住院患者进行处方审查,中国,从2019年4月到2023年3月。药剂师主导的多方面ASP干预包括指南制定,培训,药物咨询,医疗订单的审查,指标监测,和咨询。我们的主要结果是抗生素消耗。使用中断时间序列(ITS)分析来分析数据。
    结果:在实施ASP之后,我们观察到抗生素总消费量立即下降(β=-32.42DDDs/100PD和-36.24DOT/100PD,P<0.001),抗生素使用率(β=-7.87%,P=0.002),第二代头孢菌素(β=-12.43DDDs/100PD和-15.18DOT/100PD,P<0.001),第三代头孢菌素类药物(β=-5.13DDDs/100PD,P=0.001和-6.16DOT/100PD,P=0.002),氟喹诺酮类药物(β=-12.26DDDs/100PD和-12.70DOT/100PD,P<0.001),和世界卫生组织观察类别抗生素(β=-32.07DDDs/100PD和-34.96DOT/100PD,P<0.001)。干预前后的死亡率没有差异,使用ITS对住院时间(LOS)没有发现明显的短期或长期影响。然而,对平均抗生素成本有显著的短期影响(β=-446.83元,P=0.004)。
    结论:实施以药师为主导的多方面ASP在不增加LOS的前提下,对减少抗菌药物的消费产生了积极的影响。抗生素成本,或死亡率。
    BACKGROUND: Limited research has explored the effectiveness of pharmacist-led antimicrobial stewardship programs (ASPs) in the urology department.
    OBJECTIVE: To evaluate the impact of pharmacist-led multifaceted ASPs on antibiotic use and clinical outcomes.
    METHODS: We conducted a prescription review of inpatients receiving one or more antibiotics in the urology department of a large teaching hospital in Guangzhou, China, from April 2019 to March 2023. The pharmacist-led multifaceted ASPs intervention included guidelines development, training, medication consultation, review of medical orders, indicator monitoring, and consultation. Our primary outcome was antibiotic consumption. The data was analysed using interrupted time series (ITS) analysis.
    RESULTS: Following the implementation of ASPs, we observed an immediate decrease in total antibiotic consumption (β = -32.42 DDDs/100PD and -36.24 DOT/100PD, P < 0.001), Antibiotic use rate (β = -7.87 %, P = 0.002), Second-generation cephalosporins (β = -12.43 DDDs/100PD and -15.18 DOT/100PD, P < 0.001), Third-generation cephalosporins (β = -5.13 DDDs/100PD, P = 0.001 and -6.16 DOT/100PD, P = 0.002), Fluoroquinolones (β = -12.26 DDDs/100PD and -12.70 DOT/100PD, P < 0.001), and WHO Watch category antibiotics (β = -32.07 DDDs/100PD and -34.96 DOT/100PD, P < 0.001). There were no differences observed in mortality rate before and after the intervention, and no significant short-term or long-term effects were found on length of hospital stay (LOS) using ITS. However, there was a significant short-term effect on average antibiotic cost (β = -446.83 RMB, P = 0.004).
    CONCLUSIONS: The implementation of pharmacist-led multifaceted ASPs had positive impacts on reducing antimicrobial consumption without increasing LOS, antibiotic cost, or mortality rate.
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