背景:有限的研究探索了药剂师主导的抗菌药物管理计划(ASP)在泌尿科的有效性。
目的:评估药剂师主导的多方面ASP对抗生素使用和临床结果的影响。
方法:我们对在广州某大型教学医院泌尿科接受一种或多种抗生素治疗的住院患者进行处方审查,中国,从2019年4月到2023年3月。药剂师主导的多方面ASP干预包括指南制定,培训,药物咨询,医疗订单的审查,指标监测,和咨询。我们的主要结果是抗生素消耗。使用中断时间序列(ITS)分析来分析数据。
结果:在实施ASP之后,我们观察到抗生素总消费量立即下降(β=-32.42DDDs/100PD和-36.24DOT/100PD,P<0.001),抗生素使用率(β=-7.87%,P=0.002),第二代头孢菌素(β=-12.43DDDs/100PD和-15.18DOT/100PD,P<0.001),第三代头孢菌素类药物(β=-5.13DDDs/100PD,P=0.001和-6.16DOT/100PD,P=0.002),氟喹诺酮类药物(β=-12.26DDDs/100PD和-12.70DOT/100PD,P<0.001),和世界卫生组织观察类别抗生素(β=-32.07DDDs/100PD和-34.96DOT/100PD,P<0.001)。干预前后的死亡率没有差异,使用ITS对住院时间(LOS)没有发现明显的短期或长期影响。然而,对平均抗生素成本有显著的短期影响(β=-446.83元,P=0.004)。
结论:实施以药师为主导的多方面ASP在不增加LOS的前提下,对减少抗菌药物的消费产生了积极的影响。抗生素成本,或死亡率。
BACKGROUND: Limited research has explored the effectiveness of pharmacist-led antimicrobial stewardship programs (ASPs) in the
urology department.
OBJECTIVE: To evaluate the impact of pharmacist-led multifaceted ASPs on antibiotic use and clinical outcomes.
METHODS: We conducted a prescription review of inpatients receiving one or more antibiotics in the
urology department of a large teaching hospital in Guangzhou, China, from April 2019 to March 2023. The pharmacist-led multifaceted ASPs intervention included guidelines development, training, medication consultation, review of medical orders, indicator monitoring, and consultation. Our primary outcome was antibiotic consumption. The data was analysed using interrupted time series (ITS) analysis.
RESULTS: Following the implementation of ASPs, we observed an immediate decrease in total antibiotic consumption (β = -32.42 DDDs/100PD and -36.24 DOT/100PD, P < 0.001), Antibiotic use rate (β = -7.87 %, P = 0.002), Second-generation cephalosporins (β = -12.43 DDDs/100PD and -15.18 DOT/100PD, P < 0.001), Third-generation cephalosporins (β = -5.13 DDDs/100PD, P = 0.001 and -6.16 DOT/100PD, P = 0.002), Fluoroquinolones (β = -12.26 DDDs/100PD and -12.70 DOT/100PD, P < 0.001), and WHO Watch category antibiotics (β = -32.07 DDDs/100PD and -34.96 DOT/100PD, P < 0.001). There were no differences observed in mortality rate before and after the intervention, and no significant short-term or long-term effects were found on length of hospital stay (LOS) using ITS. However, there was a significant short-term effect on average antibiotic cost (β = -446.83 RMB, P = 0.004).
CONCLUSIONS: The implementation of pharmacist-led multifaceted ASPs had positive impacts on reducing antimicrobial consumption without increasing LOS, antibiotic cost, or mortality rate.