Urology

泌尿外科
  • 文章类型: Journal Article
    压力性尿失禁(SUI)影响着全世界无数的女性。鉴于ChatGPT的日益普及,患者可能会转向平台寻求SUI建议。我们的目标是评估来自ChatGPT平台的SUI临床信息的质量。
    关于SUI的最多的患者问题来自社会网站和论坛的患者材料,并使用ChatGPT3.5进行查询。ChatGPT的回应被汇编成一项调查,并分发给3名AUA指南委员会成员,他们制定了女性SUI手术管理指南。他们被要求对回答的可靠性进行评级,可理解性,质量,使用DISCERN和患者教育材料评估工具标准化问卷的可操作性。使用4点Likert量表评估准确性,并使用FleschReadingEase评分评估可读性。
    总体材料被评为中等至中等质量(DISCERN=3.73/5),具有潜在的重要但没有严重的缺点。可靠性和质量分别为63%和75%。可理解性为89%,可操作性18%,准确率为88%。所有问题域的评级均为中等或更好。所有领域的可操作性都很差。每个回答都是“难以阅读”,翻译成大学毕业生的阅读水平。
    如果患者将其用于辅助医疗指导,泌尿科社区应严格评估该平台的输出。AUA委员会成员,他们是该领域的专家,ChatGPT在SUI上产生的响应率为中等至中等高质量,中等可靠性,优秀的可理解性,使用标准化问卷的可操作性较差。材料的阅读水平提高了,这是一个潜在的改进领域,可以使生成的响应更容易理解。
    UNASSIGNED: Stress urinary incontinence (SUI) affects countless women worldwide. Given ChatGPT\'s rising ubiquity, patients may turn to the platform for SUI advice. Our objective was to evaluate the quality of clinical information about SUI from the ChatGPT platform.
    UNASSIGNED: The most-asked patient questions regarding SUI were derived from patient materials from societal websites and forums, and queried using ChatGPT 3.5. The responses from ChatGPT were compiled into a survey and disseminated to 3 AUA guideline committee members who developed the Surgical Management of Female SUI guidelines. They were asked to grade responses on reliability, understandability, quality, and actionability using DISCERN and Patient Education Materials Assessment Tool standardized questionnaires. Accuracy was assessed with a 4-point Likert scale and readability using Flesch Reading Ease score.
    UNASSIGNED: The overall material was rated as moderate to moderately high quality (DISCERN = 3.73/5) with potentially important but no serious shortcomings. Reliability and quality were reported to be 63% and 75%. Understandability was 89%, actionability 18%, and accuracy 88%. All question domains were rated at moderate or better. Actionability was poor in all domains. Every response was \"hard to read\" translating to a college graduate reading level.
    UNASSIGNED: The urologic community should critically evaluate this platform\'s output if patients are to use it for adjunctive medical guidance. AUA committee members, who are experts in the field, rate ChatGPT-produced responses on SUI as moderate to moderately high quality, moderate reliability, excellent understandability, and poor actionability utilizing standardized questionnaires. The reading level of the material was advanced, which is an area of potential improvement to make generated responses more comprehensible.
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  • 文章类型: Journal Article
    背景:先前的研究指出,对临床实践指南(CPG)的依从性各不相同,但研究尚未量化美国泌尿外科协会BPH指南的依从性。我们在新的质量改进协作(QIC)的背景下研究了指导方针的遵守情况。
    方法:收集数据作为全州QIC的一部分。对2020年1月至2022年5月接受选定CPT代码的患者的医疗记录进行回顾性审查,以了解是否遵守选定的BPH指南。
    结果:大多数男性接受经尿道前列腺电切术治疗。值得注意的是,53.3%的男性完成了IPSS,52.3%的男性进行了尿液分析。4.7%的人接受了行为改变的咨询,15.0%的药物治疗,和100%的程序选项。对于管理,79.4%服用α-受体阻滞剂,59.8%服用5-ARI。为了评估,57%有PVR,63.6%有前列腺大小测量,37.4%的人有尿流测定,12.3%的患者接受了治疗失败的咨询.术后,51.6%完成了IPSS,57%有PVR,6.50%有尿流法,50.6%停用了α-阻断剂,75.0%停止了他们的5-ARI。
    结论:遵守术前检查建议,但在初始检查和术前评估中缺乏患者咨询.我们将把数据传达给关键利益相关者,将数据收集扩展到其他机构,并制定改进实施计划。
    BACKGROUND: Previous studies noted varied adherence to clinical practice guidelines (CPGs), but studies are yet to quantify adherence to American Urological Association BPH guidelines. We studied guideline adherence in the context of a new quality improvement collaborative (QIC).
    METHODS: Data were collected as part of a statewide QIC. Medical records for patients undergoing select CPT codes from January 2020 to May 2022 were retrospectively reviewed for adherence to selected BPH guidelines.
    RESULTS: Most men were treated with transurethral resection of the prostate. Notably, 53.3% of men completed an IPSS and 52.3% had a urinalysis. 4.7% were counseled on behavioral modifications, 15.0% on medical therapy, and 100% on procedural options. For management, 79.4% were taking alpha-blockers and 59.8% were taking a 5-ARI. For evaluation, 57% had a PVR, 63.6% had prostate size measurement, 37.4% had uroflowmetry, and 12.3% were counseled about treatment failure. Postoperatively, 51.6% completed an IPSS, 57% had a PVR, 6.50% had uroflowmetry, 50.6% stopped their alpha-blocker, and 75.0% stopped their 5-ARI.
    CONCLUSIONS: There was adherence to preoperative testing recommendations, but patient counseling was lacking in the initial work-up and preoperative evaluation. We will convey the data to key stakeholders, expand data collection to other institutions, and devise an improvement implementation plan.
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  • 文章类型: Journal Article
    十多年前,美国预防服务特别工作组(USPSTF)建议在所有男性中反对基于前列腺特异性抗原(PSA)的前列腺癌筛查,这在很大程度上影响了全球范围内的前列腺癌筛查政策。因此,世界上已经看到越来越多的晚期和前列腺癌死亡,后来导致USPSTF撤回了最初的声明。同时,欧盟制定了一项指令,以解决“欧洲抗癌计划”中实施前列腺癌筛查的问题。在瑞士,有关泌尿科医生成立了一个开放的瑞士前列腺癌筛查小组,以改善前列腺癌的早期发现。2023年9月20日,瑞士泌尿外科学会(SGU/SSU)在洛桑举行的年度大会期间,成员投票赞成逐步评估在瑞士实施有组织的前列腺癌筛查计划的可行性。以下文章将总结过去十年的事件和科学进展,在此期间出现了补充基于PSA的前列腺癌筛查的证据和有希望的其他方式。它还旨在概述当代战略及其潜在的危害和好处。
    Over a decade ago, the United States Preventive Services Taskforce (USPSTF) recommended against prostate-specific antigen (PSA)-based screening for prostate cancer in all men, which considerably influenced prostate cancer screening policies worldwide after that. Consequently, the world has seen increasing numbers of advanced stages and prostate cancer deaths, which later led the USPSTF to withdraw its initial statement. Meanwhile, the European Union has elaborated a directive to address the problem of implementing prostate cancer screening in \"Europe\'s Beating Cancer Plan\". In Switzerland, concerned urologists formed an open Swiss Prostate Cancer Screening Group to improve the early detection of prostate cancer. On the 20th of September 2023, during the annual general assembly of the Swiss Society of Urology (SGU/SSU) in Lausanne, members positively voted for a stepwise approach to evaluate the feasibility of implementing organised prostate cancer screening programs in Switzerland. The following article will summarise the events and scientific advances in the last decade during which evidence and promising additional modalities to complement PSA-based prostate cancer screening have emerged. It also aims to provide an overview of contemporary strategies and their potential harms and benefits.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    目的:泌尿系感染的广泛发生和不同的临床表现对个体的健康和生活质量有显著影响。指南小组的目的是为诊断提供循证指导,治疗,和预防尿路感染(UTI)和男性附件腺感染,同时解决与感染控制和抗菌药物管理相关的关键公共卫生问题。
    方法:对于2024年泌尿系统感染指南,发现了新的相关证据,整理,并通过对文献的结构化评估进行评估。搜索的数据库包括Medline,EMBASE,和Cochrane图书馆.专家组制定了指南中的建议,以优先考虑临床上重要的护理决策。每个建议的强度是根据替代管理战略的理想和不良后果之间的平衡来确定的,证据的质量(包括估计的确定性),以及患者价值观和偏好的性质和可变性。
    主要建议强调对泌尿系感染患者进行全面病史和体格检查的重要性。该指南强调了抗菌药物管理在应对日益增长的抗菌药物耐药性威胁方面的作用。提供抗生素选择的建议,给药,根据最新证据和持续时间。
    结论:2024年EAU指南的概述为管理泌尿系统感染提供了有价值的见解,并旨在有效整合到临床实践中。
    结果:欧洲泌尿外科协会发布了关于泌尿外科感染的最新指南。指南提供了诊断建议,治疗,和预防,由于全球抗生素耐药性的威胁日益增加,因此特别关注最大限度地减少抗生素的使用。
    OBJECTIVE: Urological infections significantly impact the wellbeing and quality of life of individuals owing to their widespread occurrence and diverse clinical manifestations. The objective of the guidelines panel was to provide evidence-based guidance on the diagnosis, treatment, and prevention of urinary tract infections (UTIs) and male accessory-gland infections, while addressing crucial public health aspects related to infection control and antimicrobial stewardship.
    METHODS: For the 2024 guidelines on urological infections, new and relevant evidence was identified, collated, and appraised via a structured assessment of the literature. Databases searched included Medline, EMBASE, and the Cochrane Libraries. Recommendations within the guidelines were developed by the panel to prioritise clinically important care decisions. The strength of each recommendation was determined according to a balance between desirable and undesirable consequences of alternative management strategies, the quality of the evidence (including the certainty of estimates), and the nature and variability of patient values and preferences.
    UNASSIGNED: Key recommendations emphasise the importance of a thorough medical history and physical examination for patients with urological infections. The guidelines stress the role of antimicrobial stewardship to combat the rising threat of antimicrobial resistance, providing recommendations for antibiotic selection, dosing, and duration on the basis of the latest evidence.
    CONCLUSIONS: This overview of the 2024 EAU guidelines offers valuable insights into managing urological infections and are designed for effective integration into clinical practice.
    RESULTS: The European Association of Urology has issued an updated guideline on urological infections. The guidelines provide recommendations for diagnosis, treatment, and prevention, with a particular focus on minimising antibiotic use because of the increasing global threat of antimicrobial resistance.
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  • 文章类型: Journal Article
    尿动力学测试(UDS)是管理小儿下尿路疾病的重要工具。在标准化儿科UDS命名和技术方面已经做出了显著的努力,但是没有关于临床报告中包含的基本要素的正式指南。我们试图根据专家共识确定儿科UDS评估的理想结构和要素。
    定期执行UDS的儿科泌尿科医师使用Delphi程序进行查询。与会者被邀请代表不同的地理,经验,和社会参与。参与者在2022年11月至2023年8月之间进行了3轮问卷调查,重点是报告组织。元素,定义,和自动化电子健康记录临床决策支持。还考虑了专业计费要求。共识被定义为80%同意或反对某个主题。在随后的几轮中讨论了没有达成共识的要素。
    30个提供者的不同样本,代表美国21个州的27个机构;华盛顿,哥伦比亚特区;加拿大完成了这项研究。参与者报告每周平均解释5份UDS报告(范围1-22)。最终的共识报告根据适用的研究条件和发现确定了应包括在儿科UDS报告中的93个要素。
    这份共识报告详细介绍了儿科泌尿科专家小组同意的关键要素和结构。文档的进一步标准化应有助于UDS患者的合作和研究。根据这些信息,正在开发使用电子健康记录实施原则的标准化UDS报告模板,这将公开提供给儿科泌尿科医生。
    UNASSIGNED: Urodynamic testing (UDS) is an important tool in the management of pediatric lower urinary tract conditions. There have been notable efforts to standardize pediatric UDS nomenclature and technique, but no formal guidelines exist on essential elements to include in a clinical report. We sought to identify ideal structure and elements of a pediatric UDS assessment based on expert consensus.
    UNASSIGNED: Pediatric urologists regularly performing UDS were queried using a Delphi process. Participants were invited representing varied geographic, experience, and societal involvement. Participants underwent 3 rounds of questionnaires between November 2022 and August 2023 focusing on report organization, elements, definitions, and automated electronic health record clinical decision support. Professional billing requirements were also considered. Consensus was defined as 80% agreeing either in favor of or against a topic. Elements without consensus were discussed in subsequent rounds.
    UNASSIGNED: A diverse sample of 30 providers, representing 27 institutions across 21 US states; Washington, District of Columbia; and Canada completed the study. Participants reported interpreting an average number of 5 UDS reports per week (range 1-22). The finalized consensus report identifies 93 elements that should be included in a pediatric UDS report based on applicable study conditions and findings.
    UNASSIGNED: This consensus report details the key elements and structure agreed upon by an expert panel of pediatric urologists. Further standardization of documentation should aid collaboration and research for patients undergoing UDS. Based on this information, development of a standardized UDS report template using electronic health record implementation principles is underway, which will be openly available for pediatric urologists.
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  • 文章类型: English Abstract
    Dealing efficiently with patients suffering from pain is a central medical task. Pain, as an important function in developmental physiology, warns against damage to the body caused by external noxious agents as well as internal malfunctions and requires special attention in modern medicine. Peri- and postoperative pain is known to have a negative influence on postoperative convalescence. Treatment of tumor-related pain represents another relevant challenge in uro-oncology and palliative medicine. The updated guideline on perioperative pain therapy and palliative medicine for patients with incurable diseases or cancer is dedicated to these two topics.
    UNASSIGNED: Der effiziente Umgang mit Patient:innen, die unter Schmerzen leiden, ist eine zentrale ärztliche Aufgabe. Der Schmerz als entwicklungsphysiologisch wichtige Funktion warnt vor der Schädigung des Körpers durch externe Noxen wie auch innere Fehlfunktionen, bedarf in der modernen Medizin einer besonderen Beachtung. Bekannt ist negativen Beeinflussung der postoperativen Rekonvaleszenz durch peri- und postoperativen Schmerz. Die Therapie tumorbedingten Schmerzen stellt eine weitere relevante Herausforderung in der Uroonkologie und Palliativmedizin dar. Diesen beiden Themen widmen sich die aktualisierten Leitlinien zur perioperativen Schmerztherapie sowie zur Palliativmedizin für Patient:innen mit nicht teilbar und Krebserkrankungen.
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  • 文章类型: Journal Article
    这个欧洲放射治疗和肿瘤学会(ESTRO)项目的目的,由欧洲泌尿外科协会认可,是通过对颅外转移的立体定向消融放疗(SABR)来探索对寡转移和寡进展性肾细胞癌患者的管理的专家意见,目的是为患者选择制定共识建议,治疗剂量,同时进行全身治疗。由一个核心小组准备了关于寡转移肾细胞癌SABR的问卷,并由该领域的十名著名专家组成的小组进行了审查。采用德尔菲共识方法,向被确定为该领域关键意见领袖的临床医生发送三轮问卷。在第三轮结束时,参与者能够就37个问题中的8个达成共识。具体来说,小组成员同意对SABR候选人的年龄(25[100%)/25)和原发性肾细胞癌组织学(23[92%]/25)没有限制,在低进展患者提供消融治疗的三个病变的上限阈值,以及同时施用免疫检查点抑制剂。SABR被认为是肾细胞癌骨寡转移症(25个中的20个[80%])和肾上腺寡转移症22个(88%)的首选治疗方式。没有就适当的时间表达成共识或主要协议,但是大多数民意调查(54%-58%)保留了每隔一天的时间表,作为所有被调查地点的最佳选择。当前的ESTRODelphi共识可能为SABR在寡转移肾细胞癌中的应用提供有用的方向,并突出了正在进行的辩论的关键领域。也许指导未来的研究工作来缩小知识差距。
    The purpose of this European Society for Radiotherapy and Oncology (ESTRO) project, endorsed by the European Association of Urology, is to explore expert opinion on the management of patients with oligometastatic and oligoprogressive renal cell carcinoma by means of stereotactic ablative radiotherapy (SABR) on extracranial metastases, with the aim of developing consensus recommendations for patient selection, treatment doses, and concurrent systemic therapy. A questionnaire on SABR in oligometastatic renal cell carcinoma was prepared by a core group and reviewed by a panel of ten prominent experts in the field. The Delphi consensus methodology was applied, sending three rounds of questionnaires to clinicians identified as key opinion leaders in the field. At the end of the third round, participants were able to find consensus on eight of the 37 questions. Specifically, panellists agreed to apply no restrictions regarding age (25 [100%) of 25) and primary renal cell carcinoma histology (23 [92%] of 25) for SABR candidates, on the upper threshold of three lesions to offer ablative treatment in patients with oligoprogression, and on the concomitant administration of immune checkpoint inhibitor. SABR was indicated as the treatment modality of choice for renal cell carcinoma bone oligometatasis (20 [80%] of 25) and for adrenal oligometastases 22 (88%). No consensus or major agreement was reached regarding the appropriate schedule, but the majority of the poll (54%-58%) retained the every-other-day schedule as the optimal choice for all the investigated sites. The current ESTRO Delphi consensus might provide useful direction for the application of SABR in oligometastatic renal cell carcinoma and highlight the key areas of ongoing debate, perhaps directing future research efforts to close knowledge gaps.
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  • 文章类型: Journal Article
    尽管约占诊断为膀胱癌的患者的25%,肌肉浸润性膀胱癌(MIBC)具有显著的死亡风险,几十年来没有显著改变.越来越多,临床医师和患者认识到多学科协作工作的重要性,这些工作考虑到生存和生活质量问题.本指南提供了风险分层,治疗肌肉浸润性尿路上皮膀胱癌的临床框架。
    2024年,MIBC指南通过AUA修订程序进行了更新,在该程序中,对新发布的文献进行了审查,并将其整合到先前发布的指南中,以保持货币。该修正案允许纳入自2020年上一次修正案以来发布的其他文献。更新的搜索收集了2020年5月至2023年11月的文献。这篇综述确定了3739篇摘要,其中46人符合纳入标准。如果有足够的证据,证据体被指定为强度等级A(高),B(中等),或C(低)支持强,中等,或有条件的建议。在缺乏充分证据的情况下,其他信息作为临床原则和专家意见提供。
    更新了新辅助/辅助化疗,根治性膀胱切除术,盆腔淋巴结清扫术,多模式膀胱保留疗法,和未来的方向。酌情对方法和参考部分进行了进一步修订。
    本指南旨在根据现有证据提高临床医生评估和治疗MIBC患者的能力。未来的研究对于进一步支持或完善这些陈述以改善患者护理至关重要。
    UNASSIGNED: Although representing approximately 25% of patients diagnosed with bladder cancer, muscle-invasive bladder cancer (MIBC) carries a significant risk of death that has not significantly changed in decades. Increasingly, clinicians and patients recognize the importance of multidisciplinary collaborative efforts that take into account survival and quality of life concerns. This guideline provides a risk-stratified, clinical framework for the management of muscle-invasive urothelial bladder cancer.
    UNASSIGNED: In 2024, the MIBC guideline was updated through the AUA amendment process in which newly published literature is reviewed and integrated into previously published guidelines in an effort to maintain currency. The amendment allowed for the incorporation of additional literature released since the previous 2020 amendment. The updated search gathered literature from May 2020 to November 2023. This review identified 3739 abstracts, of which 46 met inclusion criteria.When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. In the absence of sufficient evidence, additional information is provided as Clinical Principles and Expert Opinions.
    UNASSIGNED: Updates were made regarding neoadjuvant/adjuvant chemotherapy, radical cystectomy, pelvic lymphadenectomy, multi-modal bladder preserving therapy, and future directions. Further revisions were made to the methodology and reference sections as appropriate.
    UNASSIGNED: This guideline seeks to improve clinicians\' ability to evaluate and treat patients with MIBC based on currently available evidence. Future studies will be essential to further support or refine these statements to improve patient care.
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  • 文章类型: Journal Article
    本指南的目的是为所有专业的临床医生提供基于证据的评估指导,管理,和特发性膀胱过度活动症(OAB)的治疗。该指南向读者介绍了有效的诊断过程,并通过共享的决策过程为OAB患者选择治疗方案,从而最大程度地控制症状和提高生活质量。同时尽量减少不良事件和疾病负担。
    采用OVID的电子搜索用于系统地搜索MEDLINE和EMBASE数据库,以及Cochrane图书馆,用于评估2013年1月至2023年11月OAB诊断和治疗的系统评价和主要研究。纳入和排除研究的标准基于关键问题和人群,干预措施,比较器,结果,定时,感兴趣的研究和设置类型(PICOTS)。在研究选择过程之后,纳入159项研究,并用于提供循证推荐声明。
    本指南产生了33项陈述,涵盖了对有OAB症状的患者的评估和诊断;OAB患者的治疗选择,包括非侵入性治疗,药物治疗,微创疗法,侵入性治疗,和留置导管;以及BPH和OAB患者的管理。
    一旦诊断出OAB,临床医生和OAB患者有多种治疗方案可供选择,通过共同决策,制定个性化的治疗方法,同时考虑循证建议以及患者的价值观和偏好。
    UNASSIGNED: The purpose of this guideline is to provide evidence-based guidance to clinicians of all specialties on the evaluation, management, and treatment of idiopathic overactive bladder (OAB). The guideline informs the reader on valid diagnostic processes and provides an approach to selecting treatment options for patients with OAB through the shared decision-making process, which will maximize symptom control and quality of life, while minimizing adverse events and burden of disease.
    UNASSIGNED: An electronic search employing OVID was used to systematically search the MEDLINE and EMBASE databases, as well as the Cochrane Library, for systematic reviews and primary studies evaluating diagnosis and treatment of OAB from January 2013 to November 2023. Criteria for inclusion and exclusion of studies were based on the Key Questions and the populations, interventions, comparators, outcomes, timing, types of studies and settings (PICOTS) of interest. Following the study selection process, 159 studies were included and were used to inform evidence-based recommendation statements.
    UNASSIGNED: This guideline produced 33 statements that cover the evaluation and diagnosis of the patient with symptoms suggestive of OAB; the treatment options for patients with OAB, including non-invasive therapies, pharmacotherapy, minimally invasive therapies, invasive therapies, and indwelling catheters; and the management of patients with BPH and OAB.
    UNASSIGNED: Once the diagnosis of OAB is made, the clinician and the patient with OAB have a variety of treatment options to choose from and should, through shared decision-making, formulate a personalized treatment approach taking into account evidence-based recommendations as well as patient values and preferences.
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