目的:对膀胱癌患者的血、尿检测结果异常的关注有限。本研究旨在确定血液和尿液参数是否与膀胱癌相关。
方法:我们使用病例对照设计,并将每位膀胱癌患者与三个年龄和性别相同的健康对照进行匹配。使用单变量条件逻辑回归计算粗和调整后的比值比(OR)及其95%CI。多因素条件逻辑回归用于混杂因素调整,用Spearman相关系数评估肿瘤T分期与尿液参数的相关性。
结果:招募了膀胱癌患者(n=360)和对照组(n=1050)。在单变量条件逻辑分析中,尿液pH值升高与膀胱癌风险降低相关(OR=0.67,95%CI=0.57-0.78),而尿蛋白值较高(OR=4.55,95%CI=3.36-6.15),尿糖(OR=1.56,95%CI=1.18-2.05),尿隐血(OR=4.27,95%CI=3.44~5.29)与膀胱癌风险增加相关。调整体重指数后,空腹血糖,高血压,红细胞,白细胞,淋巴细胞,中性粒细胞,和血小板,尿液pH值仍有显著性(OR=0.68,95%CI=0.53-0.88),尿蛋白(OR=1.97,95%CI=1.21-3.19),尿糖(OR=2.61,95%CI=1.39-4.89),和尿液潜血(OR=3.54,95%CI=2.73-4.58)。
结论:这项研究表明,较低的尿液pH值和较高的尿蛋白值,尿葡萄糖,尿潜血可能是膀胱癌的危险因素。
OBJECTIVE: Limited attention has been paid to abnormal blood and urine test results for patients with bladder cancer. The present study aimed to identify whether blood and urine parameters are associated with bladder cancer.
METHODS: We used a
case-control design and matched each patient with bladder cancer with three healthy controls of the same age and sex. Univariate conditional logistic regression was used to calculate the crude and adjusted odds ratio (OR) and its 95% CI. Multivariate conditional logistic regression was performed for confounders adjustment, and Spearman\'s correlation coefficient was used to assess the correlation between tumor T stages and urine parameters.
RESULTS: Patients with bladder cancer (n = 360) and controls (n = 1050) were recruited. In the univariate conditional logistic analysis, higher urine pH was associated with a decreased risk of bladder cancer (OR = 0.67, 95% CI = 0.57-0.78), while higher values of urine protein (OR = 4.55, 95% CI = 3.36-6.15), urine glucose (OR = 1.56, 95% CI = 1.18-2.05), and urine occult blood (OR = 4.27, 95% CI = 3.44-5.29) were associated with an increased risk of bladder cancer. After adjustment for body mass index, fasting blood glucose, hypertension, red blood cells, white blood cells, lymphocytes, neutrophils, and platelets, significance still remained for urine pH (OR = 0.68, 95% CI = 0.53-0.88), urine protein (OR = 1.97, 95% CI = 1.21-3.19), urine glucose (OR = 2.61, 95% CI = 1.39-4.89), and urine occult blood (OR = 3.54, 95% CI = 2.73-4.58).
CONCLUSIONS: This study indicated that lower urine pH and higher values of urine protein, urine glucose, and urine occult blood might be risk factors for bladder cancer.