背景:腺苷是一种嘌呤能信号分子,具有广泛的生理功能,包括抗疼痛和先兆感受特性。腺苷受体在三叉神经血管系统中表达,和腺苷受体拮抗剂,咖啡因,缓解偏头痛。我们对有关腺苷在偏头痛病理生理学中的作用的临床前数据文献进行了系统综述。
方法:PubMed和EMBASE于9月5日进行了关于腺苷在偏头痛病理生理学中作用的临床前研究,2021年。
结果:通过标题和摘要筛选了总共2510项研究。其中,13项评估腺苷的临床前研究,包括腺苷A1、A2A和A3受体。这些研究表明腺苷信号通路参与控制血管张力。此外,三叉神经节的电刺激可调节三叉神经节和三叉神经尾核中腺苷A1和A2A受体的表达,这与疼痛传递中的腺苷信号通路有关。
结论:临床前研究表明,由于不同的受体激活,腺苷对血管舒张和三叉神经痛通路具有双重作用,提示腺苷在偏头痛病理生理学中的可能作用。需要研究腺苷受体亚型的药理学特征,以进一步阐明其作为偏头痛治疗的潜在靶标的作用。
BACKGROUND: Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist, caffeine, relieves migraine headache. We performed a systematic
review of the literature of preclinical data addressing the role of adenosine in migraine pathophysiology.
METHODS: PubMed and EMBASE were searched for pre-clinical studies on the role of adenosine in migraine pathophysiology on September 5th, 2021.
RESULTS: A total of 2510 studies were screened by title and abstract. Of these, thirteen pre-clinical studies evaluating adenosine, adenosine A1, A2A and A3 receptors were included. These studies showed that adenosine signaling pathway is involved in controlling vascular tone. Furthermore, electrical stimulation of the trigeminal ganglion modulates the expression of adenosine A1 and A2A receptors in the trigeminal ganglion and trigeminal nucleus caudalis implicating adenosine signaling pathway in pain transmission.
CONCLUSIONS: Preclinical studies showed that adenosine has a dual effect on vasodilation and trigeminal pain pathway due to different receptor activation, suggesting a possible role of adenosine in migraine pathophysiology. Studies investigating pharmacological characteristics of subtypes of adenosine receptors are needed to further elucidate their role as a potential target for migraine treatment.