脱发,或者脱发,与几种心理社会和医学合并症有关,它仍然是个人和社会的经济负担。脱发可归因于多种机制,并具有多因素倾向,和现有的常规医疗干预措施有几个局限性。因此,目前正在探索再生医学中脱发的几种治疗策略,随着越来越多的证据表明间充质干细胞(MSC)植入,MSC来源的分泌组治疗,血液来源的富含血小板的血浆疗法是潜在的治疗选择。在这次审查中,我们搜查了Cochrane图书馆,MEDLINE(PubMed),EMBASE,和Scopus使用各种术语组合,如“干细胞,\"\"脱发,\"\"脱发,\"\"雄激素性脱发,\"\"男性型脱发,\"\"女性型脱发,\"\"再生头发的生长,细胞疗法,间充质干细胞,“\”MSC衍生的细胞外囊泡,\"\"MSC衍生的外泌体,“和“富血小板血浆”,并总结了最有希望的脱发再生治疗方法。此外,讨论了提高疗效的进一步机会和促进临床应用的创新策略。
Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities, and it remains an economic burden to individuals and the society. Alopecia is attributable to varied mechanisms and features a multifactorial predisposition, and the available conventional medical interventions have several limitations. Thus, several therapeutic strategies for alopecia in regenerative medicine are currently being explored, with increasing evidence suggesting that mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, and blood-derived platelet-rich plasma therapies are potential treatment options. In this
review, we searched the Cochrane Library, MEDLINE (PubMed), EMBASE, and Scopus using various combinations of terms, such as \"stem cell,\" \"alopecia,\" \"hair loss,\" \"Androgenetic alopecia,\" \"male-pattern hair loss,\" \"female-pattern hair loss,\" \"regenerative hair growth,\" \"cell therapy,\" \"mesenchymal stem cells,\" \"MSC-derived extracellular vesicles,\" \"MSC-derived exosomes,\" and \"platelet-rich plasma\" and summarized the most promising regenerative treatments for alopecia. Moreover, further opportunities of improving efficacy and innovative strategies for promoting clinical application were discussed.