关键词： AA, alopecia areata AA-PRP, autologous activated PRP AD-MSCs, adipose tissue derived mesenchymal stromal cells ADRCs, adipose-derived regenerative cells ADSVCs, adipose-derived stromal vascular cells AE, anagen effluvium AGA, androgenetic alopecia Alopecia BM-MSCs, bone marrow derived mesenchymal stromal cells CA, cicatricial alopecia CD, cluster of differentiation CM, conditioned medium DHT, dihydrotestosterone ECM, extracellular matrix EGF, epidermal growth factor EMA, European Medicines Agency EMI, epithelial–mesenchymal interaction EVs, extracellular vesicles FDA, United States Food and Drug Administration FGF, fibroblast growth factor FPHL, female-pattern hair loss GMP, good manufacturing practice GVHD, graft-versus-host disease HF, hair follicle HFSCs, hair follicle stem cells Hair follicle regeneration Hair loss Hair regrowth IGF, insulin-like growth factor IL, interleukin ISSCR, The International Society for Stem Cell Research KGF, keratinocyte growth factor LA, lipedematous alopecia LS, lipedematous scalp MAPK/ERK, mitogen-activated protein kinases or extracellular signal-regulated kinases MCP1, monocyte chemoattractant protein 1 MMP, matrix metalloproteinase MPHL, male-pattern hair loss MSCs, mesenchymal stromal cells OS, oxidative stress PDGF, platelet-derived growth factor PG, prostaglandin PI3K/Akt, phosphatidylinositol 3-kinase/protein kinase B PMD-Act, pharmaceuticals and Medical Devices Agency-Act PRP, platelet-rich plasma ROS, reactive oxygen species SALT, severity of alopecia tool SCs, stem cells SLE, systemic lupus erythematosus SVF, stromal vascular fraction Stem cell extracellular vesicles Stem cell therapy TA, traction alopecia TE, telogen effluvium TGF-β, transforming growth factor β TNF, tumor necrosis factor TTM, trichotillomania Th, T helper Treg, regulatory T cells VEGF, vascular endothelial growth factor Wnt, wingless/integrated-1 hDPCs, human dermal papilla cells hUC-MSCs, umbilical cord blood-derived mesenchymal stromal cells iPSC-MSCs, induced pluripotent stem cells derived mesenchymal stem cells iPSCs, induced pluripotent stem cells non-CA, non-cicatricial alopecia

来  源：   DOI：10.1016/j.reth.2022.10.005   PDF(Pubmed)

Abstract：
Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities, and it remains an economic burden to individuals and the society. Alopecia is attributable to varied mechanisms and features a multifactorial predisposition, and the available conventional medical interventions have several limitations. Thus, several therapeutic strategies for alopecia in regenerative medicine are currently being explored, with increasing evidence suggesting that mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, and blood-derived platelet-rich plasma therapies are potential treatment options. In this review, we searched the Cochrane Library, MEDLINE (PubMed), EMBASE, and Scopus using various combinations of terms, such as \"stem cell,\" \"alopecia,\" \"hair loss,\" \"Androgenetic alopecia,\" \"male-pattern hair loss,\" \"female-pattern hair loss,\" \"regenerative hair growth,\" \"cell therapy,\" \"mesenchymal stem cells,\" \"MSC-derived extracellular vesicles,\" \"MSC-derived exosomes,\" and \"platelet-rich plasma\" and summarized the most promising regenerative treatments for alopecia. Moreover, further opportunities of improving efficacy and innovative strategies for promoting clinical application were discussed.
摘要：
脱发,或者脱发,与几种心理社会和医学合并症有关，它仍然是个人和社会的经济负担。脱发可归因于多种机制，并具有多因素倾向，和现有的常规医疗干预措施有几个局限性。因此，目前正在探索再生医学中脱发的几种治疗策略，随着越来越多的证据表明间充质干细胞（MSC）植入，MSC来源的分泌组治疗，血液来源的富含血小板的血浆疗法是潜在的治疗选择。在这次审查中,我们搜查了Cochrane图书馆,MEDLINE(PubMed),EMBASE,和Scopus使用各种术语组合，如“干细胞，\"\"脱发,\"\"脱发,\"\"雄激素性脱发,\"\"男性型脱发,\"\"女性型脱发,\"\"再生头发的生长，细胞疗法,间充质干细胞，“\”MSC衍生的细胞外囊泡，\"\"MSC衍生的外泌体,“和“富血小板血浆”，并总结了最有希望的脱发再生治疗方法。此外，讨论了提高疗效的进一步机会和促进临床应用的创新策略。
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