■精神分裂症(SCZ)和自闭症谱系障碍(ASD)是神经发育疾病,其特征在于不同的精神病理学表现和不同的临床轨迹。在这两种疾病中,已经报道了谷氨酸能突触的各种改变,包括异常的NMDA和代谢型受体信号传导。
■我们进行了一项双中心研究,以评估NMDA受体相关的谷氨酸能氨基酸及其前体的血清水平,包括L-谷氨酸,L-谷氨酰胺,D-天冬氨酸,L-天冬氨酸,L-天冬酰胺,D-丝氨酸,L-丝氨酸和甘氨酸,在ASD,SCZ患者及其各自的对照受试者。具体来说,SCZ患者被细分为耐药和非耐药SCZ患者,基于他们对传统抗精神病药的反应。
■与对照组相比,SCZ患者的D-丝氨酸和D-天冬氨酸血清减少。相反,在所分析的两个ASD队列中,病例和对照组之间的氨基酸浓度没有显著差异.
■该结果进一步鼓励了未来的研究,以评估选定的D-氨基酸作为SCZ病理生理学和诊断的外周标志物的预测作用。
UNASSIGNED: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations and divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both disorders, including abnormal NMDA and metabotropic receptor signaling.
UNASSIGNED: We conducted a bicentric study to assess the blood serum levels of NMDA receptors-related glutamatergic amino acids and their precursors, including L-glutamate, L-glutamine, D-aspartate, L-aspartate, L-asparagine, D-serine, L-serine and glycine, in ASD, SCZ patients and their respective control subjects. Specifically, the SCZ patients were subdivided into treatment-resistant and non-treatment-resistant SCZ patients, based on their responsivity to conventional antipsychotics.
UNASSIGNED: D-serine and D-aspartate serum reductions were found in SCZ patients compared to controls. Conversely, no significant differences between cases and controls were found in amino acid concentrations in the two ASD cohorts analyzed.
UNASSIGNED: This result further encourages future research to evaluate the predictive role of selected D-amino acids as peripheral markers for SCZ pathophysiology and diagnosis.