Translational Science, Biomedical

翻译科学,生物医学
  • 文章类型: Journal Article
    背景:合作健康研究,如综合知识翻译(IKT),要求研究人员具有与知识用户合作的特定知识和技能。研究生往往没有机会学习如何与卫生系统或社区的知识使用者建立合作关系的技能,尽管它在研究中很重要。此环境扫描的目的是确定研究生学员在研究中使用IKT方法的可用指南。
    方法:我们进行了三个独立的系统搜索环境扫描,以确定可用于支持研究生参与IKT研究方法的指南:(i)定制的Google搜索;(ii)有针对性的加拿大大学网站搜索;(iii)向研究生课程管理员发送电子邮件,要求提供为研究生设计的指南和文件。使用标准化的数据提取工具提取数据,并使用定向内容分析方法进行分析。由于基于先验资格标准包含的结果最少,我们返回了排除的记录,以进一步审查IKT研究受训者支持的环境现状.
    结果:我们的搜索策略产生了22.900个项目,经过严格的纳入标准的两步筛选程序后,三份文件符合资格标准。所有三个文件都强调了在整个研究过程中需要IKT计划以使知识用户参与。此外,文件强调需要采取切实步骤来指导研究生与知识用户进行有效的沟通。由于缺少检索到的文档,我们对排除在外的相关IKT文件进行了事后内容分析,并确定了5个主题,表明在人际和组织层面对IKT方法的教育和参与度有所提高.
    结论:我们确定了三份文件,为受训者在健康研究中使用协作方法提供指导。该扫描强调了两个关键发现,包括支持受训者让知识用户参与研究以及与研究计划一起准备IKT计划的重要性。需要进一步的研究来共同设计指南,以支持研究生和学员参与IKT方法。
    BACKGROUND: Collaborative health research, such as integrated knowledge translation (IKT), requires researchers to have specific knowledge and skills in working in partnership with knowledge users. Graduate students are often not provided with the opportunity to learn skills in how to establish collaborative relationships with knowledge users in the health system or communities, despite its importance in research. The objective of this environmental scan is to identify available guidelines for graduate trainees to use an IKT approach in their research.
    METHODS: We conducted an environmental scan with three separate systematic searches to identify guidelines available to support graduate students in engaging in an IKT approach to research: (i) a customized Google search; (ii) a targeted Canadian university website search; and (iii) emails to administrators of graduate studies programmes asking for available guidelines and documents designed for graduate students. Data were extracted using a standardized data extraction tool and analysed using a directed content analysis approach. Due to the minimal results included based on the a priori eligibility criteria, we returned to the excluded records to further review the current state of the environment on trainee support for IKT research.
    RESULTS: Our search strategy yielded 22 900 items, and after a two-step screening process with strict inclusion criteria three documents met the eligibility criteria. All three documents highlighted the need for an IKT plan for knowledge user involvement throughout the research process. Furthermore, documents emphasized the need for tangible steps to guide graduate students to engage in effective communication with knowledge users. Due to the lack of documents retrieved, we conducted a post hoc content analysis of relevant IKT documents excluded and identified five themes demonstrating increased education and engagement in an IKT approach at an interpersonal and organizational level.
    CONCLUSIONS: We identified three documents providing guidance to trainees using a collaborative approach in their health research. This scan highlighted two key findings including the importance of supporting trainees to engage knowledge users in research and preparing an IKT plan alongside a research plan. Further research is needed to co-design guidelines to support graduate students and trainees in engaging in an IKT approach.
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    人类微生物组研究的跨学科性质使得研究结果的组织和报告跨越流行病学,生物学生物信息学,转化医学和统计学是一个挑战。用于观察性或遗传流行病学研究的常用报告指南缺乏特定于微生物组研究的关键特征。因此,一组多学科的微生物组流行病学研究人员调整了观察和遗传研究的指南,以培养独立的人类微生物组研究,并为实验室开发了新的报告元素,为微生物组研究量身定制的生物信息学和统计分析。生成的工具,名为“加强微生物组研究的组织和报告”(风暴),由17项清单组成,分为六个部分,与科学出版物的典型部分相对应,呈现为可编辑的表格,以包含在补充材料中。STORMS清单为微生物组研究的简明和完整报告提供了指导,这将有助于手稿的准备,同行评审,和读者对出版物的理解以及对出版结果的比较分析。
    The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a challenge. Commonly used reporting guidelines for observational or genetic epidemiology studies lack key features specific to microbiome studies. Therefore, a multidisciplinary group of microbiome epidemiology researchers adapted guidelines for observational and genetic studies to culture-independent human microbiome studies, and also developed new reporting elements for laboratory, bioinformatics and statistical analyses tailored to microbiome studies. The resulting tool, called \'Strengthening The Organization and Reporting of Microbiome Studies\' (STORMS), is composed of a 17-item checklist organized into six sections that correspond to the typical sections of a scientific publication, presented as an editable table for inclusion in supplementary materials. The STORMS checklist provides guidance for concise and complete reporting of microbiome studies that will facilitate manuscript preparation, peer review, and reader comprehension of publications and comparative analysis of published results.
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  • 文章类型: Review
    2010年,全球投入2400亿美元进行健康研究;不幸的是,2000亿被滥用在所研究证据的生产和报告中。大学可以帮助学生获得领导能力,将进行良好的研究成果转化为实际用途;这可能是减少投资滥用的重要举措。
    根据赤道网络和Cochrane指南进行了文献综述,然后是三轮Delphi来选择能力。
    从1121个项目中分析了11篇论文,并将39/78个识别的能力优先放在Delphi中。12名参与者中有4人被接受参与这个项目,经过三轮谈判,22项能力达成共识和稳定。这个框架将能力概念化为知识,技能,态度和价值观。能力分为四个领域:知识管理,让不同的其他人参与公共卫生倡议,培训和能力建设/变革管理和沟通。
    该框架在指导学生具备KT领导能力时,为大学提供指导。该项目强调,有效的领导应包括个人良心和自决价值观。
    In 2010, 240 billion US dollars was invested worldwide to conduct research for health; unfortunately, 200 billion was misused in the production and reporting of the evidence researched. Universities could facilitate students to acquire leadership competencies to move well-conducted research findings into practical use; this could be an essential move to reduce the misuse of investment.
    A literature review was done based on the Equator Network and Cochrane guidelines, followed by three Delphi rounds to select competencies.
    Eleven papers were analysed out of 1121 items and 39/78 identified competencies were prioritized to be presented in the Delphi. Four out of 12 participants accepted to be involved in this project, and 22 competencies reached consensus and stability after three rounds. This framework conceptualizes competencies as the knowledge, skills, attitudes and values. The competencies were framed in four domains: knowledge management, engage diverse others in public health initiatives, training and capacity building/change management and communication.
    This framework offers guidance to universities when instructing students with leadership competencies for KT. This project emphasizes that effective leadership should include personal conscience and self-determination values.
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