我们报告了一例69岁的男性,患有难治性糖尿病性舞蹈病,表现出精神症状。右舞蹈病持续3个月,难以控制糖尿病或服用氟哌啶醇和苯二氮卓类药物。只有tiapride的管理是有效的。磁共振波谱和多巴胺转运体-单光子发射计算机断层扫描显示纹状体持续缺血可能导致多巴胺转运体表达受损。从而导致间接途径的恶化。Tiapride抑制多巴胺D2受体,从而恢复间接途径的功能并导致糖尿病性舞蹈病的改善。
We report a
case of a 69-year-old man with treatment-resistant diabetic chorea presenting psychiatric symptoms. The right chorea lasted for 3 months and was refractory to control of diabetes mellitus or administration of haloperidol and benzodiazepines. Only administration of tiapride was efficacious. Magnetic resonance spectrometry and dopamine transporter-single photon emission computed tomography suggested that sustained ischemia at the striatum may lead to impaired expression of dopamine transporters, thereby resulting in deterioration in the indirect pathway. Tiapride inhibited dopamine D2 receptors, thereby restoring the function of the indirect pathway and resulting in improvement of diabetic chorea.