肌腱病是一种溃疡性皮肤病,会影响有鳍鱼类。它是由Tenacibaculum属的成员引起的,导致古怪的行为变化,包括厌食症,嗜睡,和经常导致死亡的异常游泳模式。目前,怀疑导致鱼类死亡的物种包括卵形衣原体,T.Galaicum,T.变色,T.Finnmarkense,T.中亲细胞,T.比目鱼,T.双子中心,还有T.maritimum.然而,致病成员和与疾病因果关系有关的机制,programming,由于过去十年测序工作不足,传播受到限制。在这项研究中,我们使用比较基因组学方法研究了26个公开可用的肌腱杆菌属基因组的特征,并报告了我们的观察结果.我们建议对“T”进行重新分类。LitoreumHSC22“到新加坡物种和“T”的分配。sp.4G03“物种变色(带引号的物种尚未适当命名)。我们还报告了几种抗微生物耐药性/毒力基因和少数成员私有的基因的共同出现。最后,我们挖掘了几个非BDNA形成区域,操纵子,串联重复,高置信度推定效应蛋白,和分选酶可能在细菌进化中起关键作用,转录,和发病机制。
Tenacibaculosis is an ulcerative skin disorder that affects finfish. It is caused by members of the genus Tenacibaculum, resulting in eccentric behavioural changes, including anorexia, lethargy, and abnormal swimming patterns that often result in mortality. Currently, species suspected of causing fish mortality include T. ovolyticum, T. gallaicum, T. discolor, T. finnmarkense, T. mesophilum, T. soleae, T. dicentrarchi, and T. maritimum. However, pathogenic members and the mechanisms involved in disease causation, progression, and transmission are limited due to the inadequate sequencing efforts in the past decade. In this
study, we use a comparative genomics approach to investigate the characteristic features of 26 publicly available genomes of Tenacibaculum and report our observations. We propose the reclassification of \"T. litoreum HSC 22\" to the singaporense species and assignment of \"T. sp. 4G03\" to the species discolor (species with quotation marks have not been appropriately named). We also report the co-occurrence of several antimicrobial resistance/virulence genes and genes private to a few members. Finally, we mine several non-B DNA forming regions, operons, tandem repeats, high-confidence putative effector proteins, and sortase that might play a pivotal role in bacterial evolution, transcription, and pathogenesis.