较高水平的腹内脂肪组织(IAAT),包括内脏脂肪组织(VAT),肌间脂肪组织(IMAT),和肝脏脂肪被认为是肥胖相关慢性疾病风险的驱动因素。据推测,快餐有助于IAAT模式。
我们量化了腹部皮下脂肪组织(SAT)的水平,IAAT,根据过去25年的平均快餐摄入量,中年人患代谢相关脂肪肝(MAFLD)的几率。
我们分析了年轻人冠状动脉风险发展(CARDIA)研究的数据。参与者在25年内接受了6次临床检查和测量,使用计算机断层扫描测量的增值税,SAT,和IMAT(n=3156),加上由肝脏衰减(≤40Hounsfield单位)定义的MAFLD和25年时的1种代谢异常(2010年,n=3001,n例=302)。我们估计了增值税的方式,SAT,IMAT,根据社会人口统计学和生活方式因素和逻辑回归估计25年MAFLD的比值比,根据过去25年的平均快餐摄入量类别,在25年的检查中进行肝脏衰减。
超过25年的平均快餐摄入量较高(分类如下:从不-1×/月,>1×-3×/mo,1-<2×/周,2-<3×/周,≥3×/周),增值税水平单调较高(98.5、127.6、134.5、142.0、145.5cm3),P趋势<0.0001,这在人体测量分类的肥胖类别中是一致的。肝脏脂肪也有类似的模式。有较高水平的IMAT和SAT与较高的快餐摄入量(P趋势=0.003,0.0002,分别),金额稳定在≥2×/周。此外,与从不吃快餐的参与者相比-1倍/个月,在第25年,平均快餐摄入量较高的MAFLD的可能性较高,吃快餐≥3×/周的参与者的OR为MAFLD=5.18(95%CI:2.87,9.37)。
增值税水平单调较高,肝脏脂肪,
Higher levels of intra-abdominal adipose tissue (IAAT) comprising visceral adipose tissue (VAT), intermuscular adipose tissue (IMAT), and liver fat are posited drivers of obesity-related chronic disease risk. Fast food is hypothesized to contribute to IAAT patterns.
We quantified levels of abdominal subcutaneous adipose tissue (SAT), IAAT, and odds of metabolic-associated fatty liver disease (MAFLD) in middle age according to average fast-food intake over the preceding 25 y.
We analyzed data from the Coronary Artery Risk Development in Young Adults (CARDIA)
study. Participants underwent 6 clinical exams and measurements over 25 y with computed tomography-measured VAT, SAT, and IMAT (n = 3156), plus MAFLD defined by liver attenuation (≤40 Hounsfield units) and 1 metabolic abnormality at year 25 (2010, n = 3001, n cases = 302). We estimated means of VAT, SAT, IMAT, and liver attenuation at the year 25 exam according to categories of average fast-food intake over the previous 25 y adjusted for sociodemographic and lifestyle factors and logistic regression to estimate the odds ratio of MAFLD at year 25.
With higher average fast-food intake over 25 y (categorized as follows: never-1×/mo, >1×-3×/mo, 1-<2×/wk, 2-<3×/wk, ≥3×/wk), there were monotonic higher levels of VAT (98.5, 127.6, 134.5, 142.0, 145.5 cm3), P-trend < 0.0001, which were consistent across anthropometrically classified obesity categories. There was a similar pattern with liver fat. There were higher levels of IMAT and SAT with higher fast-food intake (P-trend = 0.003, 0.0002, respectively), with amounts leveling off at ≥2×/wk. In addition, compared with participants who ate fast food never-1×/mo, there were monotonic higher odds of having MAFLD at year 25 with higher average fast-food intake, with participants who ate fast food ≥3×/wk having an OR of MAFLD = 5.18 (95% CI: 2.87, 9.37).
There were monotonic higher levels of VAT, liver fat, and odds of having MAFLD in middle age according to higher average fast-food intake over the preceding 25 y.