UNASSIGNED：这项研究的目的是调查与全膝关节置换术（TKA）发生最密切相关的骨关节炎危险因素随时间的变化。我们假设纵向病例对照研究的稳健性将提供有关TKA之前不同时间范围内各种临床和结构参数变化之间关联的新信息。
未经评估：病例（195；进入队列后的TKA）和对照（468）年龄匹配，性别,收入,WOMAC疼痛，Kellgren-Lawrence分级和随访时间来自骨关节炎倡议队列。社会人口变化之间的关联，临床,使用条件logistic回归分析对发生TKA的影像学和骨关节炎治疗进行了分析.
UNASSIGNED：WOMAC分数的恶化（cOR1.02-1.20，第0.012页），KOOS（1.02-1.04，第0.014页），膝关节损伤持续30~40年(女性2.70,p=0.034)和外翻对齐(1.10,p=0.052)与TKA的发生相关.同样与TKA相关的是外侧软骨体积损失（总体1.76，p=0.025；女性1.93，p=0.047）和内侧隔室（10%，总体1.54，p=0.027；男性2.34，p=0.008），发生内侧半月板脱出（总体1.77，p=0.046；男性2.86，p=0.028），女性的骨髓病变（BMLs）增加（1.09，p=0.048）。当WOMAC疼痛增加和软骨体积损失（1.85，p=0.001）相结合时，危险因素与TKA的关联得到加强。止痛药的使用，主要是麻醉剂和关节内类固醇注射（IASI），也与TKA有关，对软骨损失或结构的变化没有影响。
UNASSIGNED：这项研究提供了有关与TKA发生相关的危险因素的性别差异的新信息。外翻对准恶化，外侧隔室软骨体积损失，BMLs和老年损伤是女性的重要危险因素，而男性的内侧间室软骨丢失和半月板挤压。止痛药和IASI的使用尽管与TKA无关，但与TKA无关。
UNASSIGNED: The aim of this study was to investigate changes over time in osteoarthritis risk factors most closely associated with the occurrence of total knee arthroplasty (TKA). We hypothesize that the robustness of a longitudinal
case-control study will provide new information on the association between changes in various clinical and structural parameters in different time frames before TKA.
UNASSIGNED: Cases (195; TKA after cohort entry) and controls (468) matched for age, gender, income, WOMAC pain, Kellgren-Lawrence grade and follow-up duration were from the Osteoarthritis Initiative cohort. Associations between changes in sociodemographic, clinical, imaging and osteoarthritis therapies with the occurrence of TKA were performed using conditional logistic regression analyses.
UNASSIGNED: Worsening of WOMAC scores (cOR 1.02-1.20, p ⩽ 0.012), KOOS (1.02-1.04, p ⩽ 0.014), knee injuries sustained in the previous 30-40 years (women 2.70, p = 0.034) and valgus alignment (1.10, p = 0.052) were associated with the occurrence of TKA. Also associated with TKA was cartilage volume loss in the lateral (overall 1.76, p = 0.025; women 1.93, p = 0.047) and medial compartments (⩾10%, overall 1.54, p = 0.027; men 2.34, p = 0.008), occurrence of medial meniscal extrusion (overall 1.77, p = 0.046; men 2.86, p = 0.028), and increase in bone marrow lesions (BMLs) for women (1.09, p = 0.048). The association of risk factors with TKA was reinforced when both an increase in WOMAC pain and cartilage volume loss (1.85, p = 0.001) were combined. Pain medication usage, mainly narcotics and intra-articular steroid injections (IASI), was also associated with TKA, with no impact on changes in cartilage loss or structure.
UNASSIGNED: This study provides new information about gender differences in risk factors associated with the occurrence of TKA. Worsening of valgus alignment, cartilage volume loss in the lateral compartment, BMLs and older injuries are important risk factors in women, while medial compartment cartilage loss and meniscal extrusion are in men. The use of pain medication and IASI although associated was found not causal with TKA.
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