Spinal

脊柱
  • 文章类型: Case Reports
    妊娠期自发性脊髓硬膜下-硬膜外血肿很少见。
    一名29岁的GravidaII患者出现呕吐,头痛,进行性轻瘫.最初的非对比脑计算机断层扫描和凝血功能均为阴性。第二天,脊柱磁共振成像(MRI)显示有C7-T4硬膜外血肿;对比研究显示无伴随血管病变.在第3天,她接受了剖宫产,然后进行了C3-T1椎板切除术。她的感觉和括约肌功能在术后第2天恢复,但在术后6个月,她继续表现出3/5的轻瘫。
    妊娠合并急性轻瘫患者应进行脊柱STATMRI筛查,以寻找硬膜外/硬膜下血肿。
    UNASSIGNED: Spontaneous spinal subdural-epidural hematoma during pregnancy is rare.
    UNASSIGNED: A 29-year-old gravida II patient experienced the onset of vomiting, headache, and progressive paraparesis. The initial non-contrast brain computed tomography and coagulation profiles were negative. The next day, the spine magnetic resonance imaging (MRI) revealed a C7-T4 epidural hematoma; contrast studies revealed no accompanying vascular lesions. On day 3, she underwent a cesarean delivery followed by a C3-T1 laminectomy. Her sensory and sphincteric function returned on postoperative day 2, but at 6 postoperative months, she continued to exhibit a 3/5 paraparesis.
    UNASSIGNED: Pregnant patients with acute paraparesis should undergo STAT MRI screening of the spine to look for epidural/subdural hematomas.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:非典型畸胎样/横纹肌样瘤(AT/RT)是一种罕见的恶性肿瘤,很少发生在脊柱间隙,尤其是在马尾.仅报道了8例小儿马尾草AT/RT。因此,其临床行为和最佳治疗仍不清楚。
    方法:作者描述了一个9岁男孩出现进行性背部和左腿疼痛的案例。最初的磁共振成像显示L3-4级别的硬膜内髓外病变,在一个月内迅速发展到L2-5水平。他接受了L2-5椎板切除术的部分切除肿瘤。病理诊断为AT/RT。他接受了辅助化疗和放疗,他的步态障碍在术后有所改善。在6个月的随访中,未观察到疾病复发。
    结论:虽然极为罕见,鉴别诊断中应包括AT/RT,以便及时进行治疗干预。具有最小功能损害的安全切除,术后放化疗,可以导致肿瘤控制和改善神经功能。https://thejns.org/doi/10.3171/CASE24219。
    BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon malignant neoplasm and rarely occurs in the spinal space, especially in the cauda equina. Only 8 cases of pediatric AT/RT of the cauda equina have been reported. Therefore, its clinical behavior and optimal treatment remain unclear.
    METHODS: The authors describe the case of a 9-year-old boy who presented with progressive back and left leg pain. Initial magnetic resonance imaging showed an intradural extramedullary lesion at the L3-4 level, which progressed rapidly to the L2-5 level within a month. He underwent partial resection of the tumor with an L2-5 laminectomy. The histopathological diagnosis was AT/RT. He received adjuvant chemotherapy and radiotherapy, and his gait disturbance improved postoperatively. At 6 months\' follow-up, disease recurrence was not observed.
    CONCLUSIONS: Although extremely rare, AT/RT should be included in the differential diagnosis for prompt therapeutic intervention. Safe resection with minimal functional impairment, followed by postoperative chemoradiation, can lead to tumor control and improve neurological function. https://thejns.org/doi/10.3171/CASE24219.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    脊柱受累是人类布鲁氏菌病的常见但严重的并发症。然而,关于布鲁氏菌病患者脊髓受累相关危险因素的信息有限.
    这项回顾性病例对照研究旨在确定与布鲁氏菌病住院患者脊柱并发症相关的潜在危险因素。
    在研究期间,在377名患者中诊断出布鲁氏菌病,其中108人(28.64%)出现脊髓受累。脊柱受累的患者明显比对照组的患者年龄大(平均年龄[标准差],53.25[10.48]对43.12[13.84]年,分别;P<.001)。脊柱受累患者的诊断延迟明显长于对照组(平均延迟[标准差],11.17[13.55]vs6.03[8.02]周;P=.001)。年龄>40岁(赔率比,5.42[95%置信区间,2.65-11.05];P<.001)和诊断延迟>4周(2.94[1.62-5.35];P<.001)与布鲁氏菌病的脊髓受累独立相关。L3-5水平的腰椎受影响最大(249中的152[61.04%])。两组之间的背痛(病例患者108中的92例与对照组108中的21例;P<.001)和脾肿大(分别为108中的23例与42例;P=.005)显着差异。
    年龄>40岁和诊断延迟>4周增加了布鲁氏菌病脊柱受累的风险。因此,从症状发作到诊断的时间应该缩短,采取有效措施降低脊柱受累风险。
    UNASSIGNED: Spinal involvement is a common but serious complication of human brucellosis. However, information on the risk factors associated with spinal involvement in individuals with brucellosis is limited.
    UNASSIGNED: This retrospective case-control study aimed to determine the potential risk factors associated with spinal complications in inpatients with brucellosis.
    UNASSIGNED: During the study period, brucellosis was diagnosed in 377 patients, of whom 108 (28.64%) showed spinal involvement. Those with spinal involvement were significantly older than patients in the control group (mean age [standard deviation], 53.25 [10.48] vs 43.12 [13.84] years, respectively; P < .001). The diagnostic delays were significantly longer in patients with spinal involvement than in the control group (mean delay [standard deviation], 11.17 [13.55] vs 6.03 [8.02] weeks; P = .001). Age >40 years (odds ratio, 5.42 [95% confidence interval, 2.65-11.05]; P < .001) and diagnostic delay >4 weeks (2.94 [1.62-5.35]; P < .001) were independently associated with spinal involvement in brucellosis. The lumbar spine at the L3-5 level was the most affected (152 of 249 [61.04%]). Back pain (92 of 108 in case patients vs 21 of 108 in controls; P < .001) and splenomegaly (23 vs 42 of 108, respectively; P = .005) differed significantly between the 2 groups.
    UNASSIGNED: Age >40 years and diagnostic delay >4 weeks increased the risk of spinal involvement in brucellosis. Therefore, the time from symptom onset to diagnosis should be shortened, using effective measures to reduce spinal involvement risk.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Systematic Review
    背景:广泛的脊髓硬膜外脓肿(ESEA)是一种罕见的临床实体,需要延迟诊断,这可以通过硬膜外收集的扩展来解释,从而延迟其临床表现的质量效应。
    方法:我们报告了一例54岁接受抗生素治疗的男性患者出现广泛的C7至T10硬膜外脓肿的罕见病例,椎板切除术,脓肿引流。此外,我们根据“系统评价的首选报告项目”指南进行了系统的文献检索。从PubMed数据库中确定了报告ESEA患者的相关研究(1980年至2023年)。
    结果:本研究共纳入48项研究报告55名患者,平均年龄为55.7±14.6岁,男性占61.8%(n=34)。中位随访时间为38个月[21.5-64.3]。ESEA的死亡率为1.8%,发病率为21.8%,据报道76.4%(n=42)在手术后有所改善。
    结论:单层和多层椎板切除术联合脓肿引流治疗广泛的脊髓硬膜外脓肿均可使患者从这种破坏性疾病中恢复。需要使用Nadir时间和Nadir手术数据评估结果,以编纂ESEA管理。
    BACKGROUND: Extensive spinal epidural abscess (ESEA) is a rare clinical entity subject to delayed diagnosis, which can be explained by the extension of the epidural collection, thereby delaying the mass effect responsible for its clinical manifestations.
    METHODS: We report a rare case of an extensive C7-T10 epidural abscess in a 54-year-old man treated with antibiotics, laminectomy, and abscess drainage. In addition, we conducted a systematic literature search according to the \"Preferred Reporting Items for Systematic Reviews\" guidelines. Relevant studies (1980-2023) reporting patients with ESEA were identified from PubMed databases.
    RESULTS: A total of 48 studies reporting 55 patients were included in this study with a mean age of 55.7 ± 14.6 years with a male predominance of 61.8% (n = 34). The median duration of follow-up was 38 months (21.5-64.3). The mortality rate of ESEA was 1.8% for a 21.8% morbidity rate with 76.4% (n = 42) reported to have been improved after surgery.
    CONCLUSIONS: Both single and multilevel laminectomy with abscess drainage for ESEA leads to patient recovery from this devastating condition. Evaluation of the outcome with data on time-to-Nadir and Nadir-to-surgery is needed to codify ESEA management.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Journal Article
    颈椎病是一种罕见的病理,发病率为每10万人0.5-2.5,带来重大潜在风险。这种类型的感染可导致高达29%的患者的神经功能缺损。感染段的根治性手术清创术,聚变,静脉注射抗生素方案仍然是大多数脊柱中心的金标准。本研究旨在根据疾病严重程度分析三级脊柱中心的手术结果。
    在这项研究中,我们回顾性纳入了2017年1月至2022年5月在奥格斯堡大学医院接受治疗的所有诊断为颈椎病的患者.我们收集并分析了有症状的临床表现的基线参数,实验室参数,放射学外观,和手术参数,如方法和植入物的类型,以及神经和放射学结果。使用SPSS进行描述性统计,并对独立样本采用t检验和卡方检验进行相关相关性检验。
    确定了24例(9%)患有颈椎病的患者。22例(92%)经手术治疗的患者被细分为复杂椎间盘炎组(n=14,64%)和无复杂椎间盘炎组(n=8,36%)。17名患者(71%)入院时出现败血症,17例患者(71%)在主要影像学上诊断为硬膜外脓肿,5例患者(21%)在远处的脊柱节段有一个以上的椎间盘炎病变。硬膜外脓肿的存在与全身性脓毒症(OR=6.2;p=0.03)和脊髓病症状(OR=14.4;p=0.00)显着相关。最常见的标本是多敏金黄色葡萄球菌(10例,42%)。6名患者(25%)在中位20天后死亡,尽管有准确的抗生素治疗,其中五人被诊断出患有复杂的椎间盘炎。15例(63%)的随访数据显示9例(38%)的永久性神经损伤。值得注意的是,手术方式是翻修手术的重要因素(p=0.008),因为五分之三(60%)患有复杂椎间盘炎的腹背侧病例进行了修订。
    颈椎病是一种严重的传染病,通常与永久性神经损伤或致命后果有关。尽管有足够的手术和抗生素治疗。复杂类型的椎间盘炎可能需要更具挑战性的手术和临床过程。
    UNASSIGNED: Cervical spondylodiscitis is a rare pathology, with an incidence of 0.5-2.5 per 100,000 population, posing significant potential risks. This type of infection can lead to neurological impairment in up to 29% of patients. Radical surgical debridement of the infected segment, fusion, and an intravenous antibiotic regimen remains the gold standard in most spine centers. This study aimed to analyze the surgical outcome in a tertiary spine center based on disease severity.
    UNASSIGNED: In this study, we retrospectively included all patients diagnosed with cervical spondylodiscitis and treated at the University Hospital Augsburg between January 2017 and May 2022. We collected and analyzed baseline parameters on clinical presentation with symptoms, laboratory parameters, radiological appearance, and surgical parameters such as type of approach and implant, as well as neurological and radiological outcomes. Descriptive statistics were performed using SPSS, and relevant correlations were examined using the t-test for independent samples and the chi-square test.
    UNASSIGNED: Twenty-four patients (9%) with cervical spondylodiscitis were identified. Twenty-two (92%) surgically treated patients were subdivided into the complicated discitis group (n = 14, 64%) and the uncomplicated discitis group (n = 8, 36%). Seventeen patients (71%) presented with sepsis on admission, 17 patients (71%) were diagnosed with epidural abscess on primary imaging, and 5 patients (21%) had more than one discitis lesion at a distant spinal segment. The presence of epidural abscess was significantly associated with systemic sepsis (OR = 6.2; p = 0.03) and myelopathy symptoms (OR = 14.4; p = 0.00). The most frequently detected specimen was a multisensitive Staphylococcus aureus (10 patients, 42%). Six patients (25%) died after a median of 20 days despite antibiogram-accurate therapy, five of whom were diagnosed with a complicated type of discitis. The follow-up data of 15 patients (63%) revealed permanent neurological damage in 9 patients (38%). Notably, the surgical approach was a significant factor for revision surgery (p = 0.008), as three out of five (60%) ventrodorsal cases with complicated discitis were revised.
    UNASSIGNED: Cervical spondylodiscitis represents a severe infectious disease that is often associated with permanent neurological damage or a fatal outcome, despite adequate surgical and antibiotic treatments. Complicated types of discitis may require a more challenging surgical and clinical course.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    脊髓硬膜外脓肿是一种罕见但严重的疾病,预后不良。这是新背痛的经典三合会,神经功能缺损和发热仅在15%的病例中出现,最初在75-89%的病例中被误诊。6,7延迟治疗与较差的预后相关。谵妄本身是死亡的危险因素,但认知和记忆障碍也会使临床评估复杂化。1,2,3,4,5和模糊,脊髓硬膜外脓肿。这个病例突出了诊断脊髓硬膜外脓肿的困难,需要对病情有很高的怀疑指数,并及时采取行动将发病率降至最低。此外,它证明了将无法解释的谵妄作为急诊治疗的价值和诊断性过早关闭的危险。最后,对困惑和不合作的患者进行持续临床检查的重要性。
    Spinal epidural abscess is a rare but serious condition with poor outcomes. It\'s classic triad of new back pain, neurological deficit and fever is only present in 15% of cases at presentation and is initially misdiagnosed in 75-89%.6,7 Delaying treatment is associated with worse outcomes. Delirium is itself a risk factor for mortality but the disturbance in cognition and memory can also complicate clinical assessment.1-5 We present a case of delirium caused by, and obscuring, a spinal epidural abscess. This case highlights the difficulties in diagnosing spinal epidural abscesses, the need for a high index of suspicion for the condition and timely action to minimise morbidity. In addition, it demonstrates the value of treating unexplained delirium as an emergency and the danger of diagnostic premature closure. Finally, the importance of persistent clinical examination of the confused and non-cooperative patient.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    血吸虫病,一种寄生虫病,是由血吸虫属的血吸虫引起的。神经血吸虫病是最严重的血吸虫病,当宿主的大脑和脊髓对卵子的沉积作出反应时,导致神经症状.神经血吸虫病引起各种体征和症状,比如脊髓病,神经根病,颅内压升高.
    一名来自埃塞俄比亚的12岁儿童,下肢进行性无力,持续2个月。除了弱点,患者下肢也有刺痛感和麻木。此外,他有膀胱和肠失禁。脊柱MRI显示有粘液乳头状室管膜瘤的征象,但组织病理学结果显示血吸虫病。术后,患者的下肢无力(手指闪烁)略有改善。然而,他的节制能力没有改善。
    曼氏血吸虫感染最常见的神经系统表现是脊髓病,其中包括亚急性脊髓病和急性横贯性脊髓炎。马尾和延髓圆锥是最常受影响的区域。
    当脊柱血吸虫病表现为模仿脊柱肿瘤时,它提出了一个复杂的临床挑战,需要一个全面的跨学科方法,以确保准确的诊断和有效的治疗。这是当务之急的保健医生,以提高他们的知识和这种罕见的寄生虫感染的认识,特别是在流行的地区。
    UNASSIGNED: Schistosomiasis, a parasitic disease, is caused by blood flukes from the schistosoma genus. Neuroschistosomiasis is the most severe form of schistosomiasis, which occurs when the host\'s brain and spinal cord react to the deposition of eggs, leading to neurological symptoms. Neuroschistosomiasis causes various signs and symptoms, such as myelopathy, radiculopathy, and elevated intracranial pressure.
    UNASSIGNED: A 12-year-old child from Ethiopia who presented with progressive weakness in his lower extremities that has been ongoing for 2 months. Alongside the weakness, the patient also experienced tingling sensations and numbness in his lower extremities. Additionally, he had bladder and bowel incontinence. Spinal MRI showed signs suggestive of myxopapillary ependymoma, but the histopathology result showed schistosomiasis. Postoperatively, the patient had a slight improvement in terms of lower extremity weakness (flickering of the digits). However, there was no improvement in his continence ability.
    UNASSIGNED: The most common neurological manifestation of Schistosoma mansoni infection is myelopathy, which includes subacute myeloradiculopathy and acute transverse myelitis. The cauda equina and conus medullaris are the areas most frequently affected.
    UNASSIGNED: When spinal schistosomiasis presents itself as a mimicking spinal tumour, it poses a complex clinical challenge that necessitates a comprehensive interdisciplinary approach to ensure accurate diagnosis and effective treatment. It is imperative for healthcare practitioners to enhance their knowledge and awareness of this uncommon parasitic infection, particularly in regions where it is prevalent.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    毛细血管瘤,通常在皮肤和粘膜组织中发现,很少在脊髓内遇到,提出了重大的诊断挑战。我们报告了一名66岁女性患者的脊髓圆锥硬膜内髓外毛细血管瘤的罕见病例。由于存在囊性形成和壁结节增强,因此根据MRI发现,我们的初步诊断倾向于囊性血管母细胞瘤。然而,手术探查和随后的病理检查显示病变为毛细血管血管瘤。就作者所知,该病例可能是首次有文献记载的脊髓毛细血管瘤,其模拟囊性血管母细胞瘤。
    Capillary hemangiomas, usually found in skin and mucosal tissues, are rarely encountered within the spinal cord, presenting a significant diagnostic challenge. We report a rare case of intradural extramedullary capillary hemangioma at the conus medullaris in a 66-year-old female patient. Our initial diagnosis leaned towards a cystic hemangioblastoma based on MRI findings due to the presence of cystic formation with an enhanced mural nodule. However, surgical exploration and subsequent pathological examination revealed the lesion as a capillary hemangioma. To the authors\' knowledge, this case may represent the first documented instance of a spinal capillary hemangioma that mimics a cystic hemangioblastoma.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Systematic Review
    背景:髓内脑膜瘤是一种极为罕见的脊柱肿瘤亚型,仅占原发性脊柱肿瘤的5%。鉴于它们的稀缺性和独特的特征,了解最佳管理方法对于改善临床决策至关重要。本系统综述旨在巩固现有文献,并提供详细的病例说明,以增强对这种罕见脊柱肿瘤实体的理解。
    方法:根据系统评价和Meta分析指南的首选报告项目进行系统检索。符合条件的研究包括病例报告,案例系列,队列研究,reviews,和荟萃分析。数据提取和综合侧重于人口特征,肿瘤位置,临床表现,影像学发现,手术干预,组织病理学特征,和结果。
    结果:系统评价共纳入15篇高质量的科学文章,提供有关髓内脑膜瘤各个方面的见解。人口统计学分析显示,受影响患者的年龄分布广泛,性别分布相等。常见的临床表现包括行走困难,感觉障碍,痉挛性轻瘫,和尿失禁.神经影像学检查结果表明,T1和T2加权图像上的信号强度变化不均匀,在钆增强的图像上具有可变的增强模式。手术干预,主要是全切除,在大多数情况下导致良好的术后结局。
    结论:髓内脑膜瘤由于其稀有性和独特的特点,提出了诊断和治疗的挑战。量身定制的手术方法,结合术中神经生理监测和荧光辅助切除等技术,对于减少神经功能缺损和优化患者预后至关重要。尽管他们的频率不高,在脊柱肿瘤的鉴别诊断中认识髓内脑膜瘤对于及时诊断和及时干预至关重要。最终改善患者预后。
    BACKGROUND: Intramedullary meningiomas are an exceptionally rare subtype of spinal tumors, accounting for only 5% of primary spinal neoplasms. Given their scarcity and unique characteristics, understanding optimal management approaches is crucial for improved clinical decision-making. This systematic review aims to consolidate existing literature and present a detailed case illustration to enhance understanding of this uncommon spinal tumor entity.
    METHODS: A systematic search adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted. Eligible studies included case reports, case series, cohort studies, reviews, and meta-analyses. Data extraction and synthesis focused on demographic characteristics, tumor location, clinical presentation, imaging findings, surgical interventions, histopathological features, and outcomes.
    RESULTS: A total of 15 high-quality scientific articles were included in the systematic review, providing insights into various aspects of intramedullary meningiomas. Demographic analysis revealed a broad age distribution with an equal gender distribution among affected patients. Common clinical presentations included difficulty walking, sensory disturbances, spastic paraparesis, and urinary incontinence. Neuroimaging findings demonstrated heterogeneous signal intensity variations on T1- and T2-weighted images, with variable enhancement patterns on gadolinium-enhanced images. Surgical interventions, predominantly total resection, resulted in favorable postoperative outcomes in most cases.
    CONCLUSIONS: Intramedullary meningiomas pose diagnostic and therapeutic challenges due to their rarity and unique characteristics. Tailored surgical approaches, incorporating techniques such as intraoperative neurophysiological monitoring and fluorescence-aided resection, are crucial for minimizing neurological deficits and optimizing patient outcomes. Despite their infrequency, recognizing intramedullary meningiomas in the differential diagnosis of spinal tumors is essential for prompt diagnosis and timely intervention, ultimately improving patient prognosis.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

    求助全文

  • 文章类型: Case Reports
    脊髓硬膜外动静脉瘘合并骶动静脉畸形(AVM)是一种罕见的脊髓动静脉瘘。有两种类型的脊髓硬膜外动静脉瘘(SEDAVFs),1型涉及硬膜内静脉引流,2型不涉及硬膜内静脉引流。我们介绍了1例经动脉栓塞治疗1型SEDAVFs与骶骨AVM的病例。在8个月内,一名14岁男孩表现为下肢逐渐变弱和膀胱肠功能障碍。整个脊柱的磁共振成像(MRI)显示胸椎脊髓充血,从腰骶骨区域到延髓圆锥的单个扩张的流动空隙,并继续通过髓周静脉引流至C5水平。在栓塞AVMnidus后,通过优先喂食器填充静脉囊。三个月后,临床随访显示运动功能改善,虽然温和。SEDAVF1型的血管内治疗可能已实现完全闭塞,而没有任何手术并发症。然而,它可以是非常具有挑战性的,由于多个馈线和AVMnidus像在这种情况下的存在。然而,在瘘管病例中最困难的事情是建立诊断和找到瘘管点。需要早期治疗,由于长期的病变可能造成不可逆的损伤。
    Spinal epidural arteriovenous fistulas with sacral arteriovenous malformation (AVM) are a rare type of spinal arteriovenous fistulas. There are two varieties of spinal epidural arteriovenous fistulas (SEDAVFs), with type 1 involving intradural venous drainage and type 2 not involving intradural venous drainage. We present a case of transarterial embolization for type 1 SEDAVFs with sacral AVM. Within 8 months, a 14-year-old boy presented with progressively weaker lower extremities and bladder-bowel dysfunction. Magnetic resonance imaging (MRI) of the whole spine revealed thoracic spinal cord congestion, a single dilated flow void running from the lumbosacral area to the conus medullaris, and continuing cranial draining up to the C5 level via the perimedullary vein. Filling of the venous sac through a preferential feeder after embolizing the AVM nidus was performed. After 3 months, the clinical follow-up showed improvement of motoric function, although mild. Endovascular treatment for SEDAVF type 1 might have achieved total obliteration without any procedural complications. Nevertheless, it can be very challenging due to multiple feeders and the presence of an AVM nidus like in this case. However, the most difficult thing in fistula cases is establishing the diagnosis and finding the fistula point. Early treatment is required, due to the fact that longstanding lesions could cause irreversible damage.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号