UNASSIGNED: The COVID-19 pandemic is a new phenomenon and has affected the population\'s lifestyle in many ways, such as panic buying (the so-called \"hamster shopping\"), adoption of home-office, and decline in retail shopping. For transportation planners and operators, it is interesting to analyze the spatial factors\' role in the demand patterns at a POI (Point of Interest) during the COVID-19 lockdown viz-a-viz before lockdown.
UNASSIGNED: This study illustrates a use-case of the POI visitation rate or popularity data and other publicly available data to analyze demand patterns and spatial factors during a highly dynamic and disruptive event like COVID-19. We develop regression models to analyze the correlation of the spatial and non-spatial attributes with the POI popularity before and during COVID-19 lockdown in Munich by using lockdown (treatment) as a dummy variable, with main and interaction effects.
UNASSIGNED: In our case-study for Munich, we find consistent behavior of features like stop distance and day-of-the-week in explaining the popularity. The parking area is found to be correlated only in the non-linear models. Interactions of lockdown with POI type, stop-distance, and day-of-the-week are found to be strongly significant. The results might not be transferable to other cities due to the presence of different city-specific factors.
UNASSIGNED: The findings from our case-study provide evidence of the impact of the restrictions on POIs and show the significant correlation of POI-type and stop distance with POI popularity. These results suggest local and temporal variability in the impact due to the restrictions, which can impact how cities adapt their transport services to the distinct demand and resulting mobility patterns during future disruptive events.

Aba\'s topography, weather, and climate make it prone to landslides, mudslides, and other natural disasters, which limit economic and social growth. Assessing and improving regional resilience is important to mitigate natural disasters and achieve sustainable development. In this paper, the entropy weight method is used to calculate the resilience of Aba under multi-hazard stress from 2010 to 2018 by combining the existing framework with the disaster resilience of the place (DROP) model. Then spatial-temporal characteristics are analyzed based on the coefficient of variation and exploratory spatial data analysis (ESDA). Finally, partial least squares (PLS) regression is used to identify the key influences on disaster resilience. The results show that (1) the disaster resilience in Aba increased from 2010 to 2018 but dropped in 2013 and 2017 due to large-scale disasters. (2) There are temporal and spatial differences in the level of development in each of the Aba counties. From 2010 to 2016, disaster resilience shows a significant positive spatial association and high-high (HH) aggregation in the east and low-low (LL) aggregation in the west. Then the spatial aggregation weakened after 2017. This paper proposes integrating regional development, strengthening the development level building, and emphasizing disaster management for Aba.

OBJECTIVE: Clarification of propagation patterns in amyotrophic lateral sclerosis (ALS) is challenging, but understanding these has implications for individual prognostication and clinical trial design. However, systematic knowledge in this area is lacking. The aim of this study was to characterize the spatial and temporal features of propagation patterns in ALS, and to evaluate the association between propagation patterns and survival.
METHODS: A cohort of 833 patients with ALS, diagnosed between January 2018 and December 2019 and followed to August 2021, was analysed. Spatial and temporal features of propagation patterns were determined based on the involved functional regions (bulbar, cervical, thoracic/respiratory and lumbar) in time order. The final propagation pattern was identified in patients with at least three functional regions involved. Kaplan-Meier analysis and Cox regression analysis were performed.
RESULTS: During a median follow-up of 21.2 months, 19 final propagation patterns were identified in 657 patients (78.9%). In survival analysis, we found that the earlier the respiratory functional region becomes involved, the higher the risk of death (time order: 1st: hazard ratio [HR], 3.35, 95% confidence interval [CI] 1.23-9.15; 2nd: HR 2.45, 95% CI 1.55-3.87; 3rd: HR 1.94, 95% CI 1.52-2.49), adjusting for age, sex, diagnostic delay, revised ALS Functional Rating Scale score, cognitive impairment and riluzole. Shorter interval time between involved regions was an independent adverse prognostic factor.
CONCLUSIONS: The propagation patterns of ALS are varied. The order in which the respiratory region becomes involved and the interval time between involvement of functional regions are predictors for prognosis.

Objectives: This was a long-term retrospective study, aiming to understand the temporal and spatial trend of cirrhosis in Wuwei from 1995 to 2016, explore its spatio-temporal aggregation, and find out the high incidence areas. To provide theoretical basis for the formulation of comprehensive prevention and treatment strategy of cirrhosis in Wuwei. Methods: Herein, we extracted data of cirrhosis patients who were treated in 12 sentinel hospitals in Wuwei from their medical records. We used SAS and Joinpoint Regression Program for data analysis, SaTScan 9.4 software for clustering area detection, and ArcGIS 10.2 software for geographical distribution mapping. Results: Among 3308 patients with liver cirrhosis (average age, 55.34 years) included in this study, 15.9% were aged 50-54 years. The majority were men (2716, 65.8%), with a sex ratio of 1.92:1 and peasants by occupation (1369, 60.3%). The basic social medical insurance system covered the healthcare costs of 1271 patients (63%). A Joinpoint regression analysis done for 1995-2016 revealed an increase in the standardized cirrhosis rate [average annual percent change (AAPC) = 16.7% (95% CI, 10.2-23.5%)] with three joinpoints in 2010, 2013, and 2016. The annual percent change (APC) from 1995 to 2010 was 11.13% (95% CI: 6.5-16.0), and APC from 2010 to 2013 was 66.48% (95% CI:16.0-138.9); conversely, from 2013 to 2016, APC was 4.4% (95% CI, -7.5-17.8%). Hongshagang Town showed the highest average incidence. Each township showed a gradual increase in the incidence after 2010. The results revealed that in each township, liver cirrhosis incidence had some spatial aggregation and was nonrandom. Four liver cirrhosis clusters were noted in 75 townships in Wuwei. Data were gathered from 2011 to 2016. Conclusions: From 1995 to 2016, the incidence of cirrhosis in Wuwei still showed an increasing trend, but the growth rate slowed down since 2013. In Wuwei, the rate of standardization of cirrhosis in female patients increased steadily and faster than in male patients. It is necessary to strengthen the diagnosis, treatment, prevention, and control measures of cirrhosis-related diseases. The results of spatial scanning, basic spatial distribution, aggregation time, and time trend analysis were consistent.

Weather change such as raining is a crucial factor to cause traffic congestion, especially in metropolises with the limited sewer system infrastructures. Identifying the roads which are sensitive to weather changes, defined as weather-sensitive roads (WSR), can facilitate the infrastructure development. In the literature, little research focused on studying weather factors of developing countries that might have deficient infrastructures. In this research, to fill the gap, the real-world data associating with Jakarta, Indonesia, was studied to identify WSR based on smartphone sensor data, real-time weather information, and road characteristics datasets. A spatial-temporal congestion speed matrix (STC) was proposed to illustrate traffic speed changes over time. Under the proposed STC, a sequential clustering and classification framework was applied to identify the WSR in terms of traffic speed. In this work, the causes of WSR were evaluated based on the variables\' importance of the classification method. The experimental results show that the proposed method can cluster the roads according to the pattern changes in the traffic speed caused by weather change. Based on the results, we found that the distances to shopping malls, mosques, schools, and the roads\' altitude, length, width, and the number of lanes are highly correlated to WSR in Jakarta.