目的:本研究旨在通过荟萃分析评估早期乳腺癌与体型之间的关系,并给出相应的建议。
方法:到2021年4月5日的观察性研究,这些研究探索有/无乳腺癌的女性,这些女性在18岁之前使用StunkardFigure评定量表/SørensenSomatotypes评估其体型和远处乳腺癌风险。使用随机/固定效应模型,估计了合并相对风险(RR)和95%置信区间(CIs).然后使用受限三次样条分析进行非线性剂量-反应荟萃分析。
结果:纳入了涉及来自341,905名个体的15,211名乳腺癌患者的六篇文章,用于对早期体型和乳腺癌风险进行荟萃分析。汇总结果表明,随着体型的增加,保护作用变得更强,直到达到6。受限三次样条模型表明体型与乳腺癌之间存在线性关系(P非线性=0.533)。绝经状态的亚组分析显示,从3型到6型,儿童期增加的体型对绝经后乳腺癌的保护作用越来越大,增加0.887倍(RR=0.887,95%CI:0.842,0.934)至0.759倍(RR=0.759,95%CI:0.631,0.913)降低了乳腺癌的风险(P非线性=0.880)。但在绝经前乳腺癌患者中没有发现这种关联(P-非线性=0.757).当按年龄分层时,在10岁以下的人群中,体型的增加与乳腺癌风险的统计学显著降低相关.从体型3到体型6,患乳腺癌的风险降低了9.7-27.7%(P非线性=0.175)。
结论:早期肥胖,我们的数据支持与乳腺癌风险呈负相关,特别是年龄小于10岁和绝经后妇女。由于超重的女孩可能在成年期仍然超重甚至肥胖。虽然超重和肥胖的成年人患乳腺癌和其他类型的癌症和各种慢性疾病的风险增加。因此,我们建议儿童在生命的所有时期都应保持正常或稍胖的体型。
This study aims to evaluate the relationship between breast cancer and
somatotypes during early life by meta-analysis and give the corresponding advice.
Observational studies till April 5, 2021, which explore women with/without breast cancer who used the Stunkard Figure Rating Scale/Sørensen
Somatotypes to evaluate their somatotype before 18 years of age and distant breast cancer risk were included. Using random/fixed-effect models, the pooled relative risks (RRs) and 95% confidence intervals (CIs) were estimated. Then a nonlinear dose-response meta-analysis was conducted using restricted cubic spline analysis.
Six articles involving 15,211 breast cancer patients from 341,905 individuals were included for performing a meta-analysis of early somatotype and breast cancer risk. The pooled results showed that the protection became stronger with the increase of somatotype until it reached 6. The restricted cubic spline model indicated a linear relationship between
somatotypes and breast cancer (P-nonlinearity = 0.533). Subgroup analysis of menopausal status showed that increasing somatotype during childhood was increasingly protective against postmenopausal breast cancer from somatotype 3 to somatotype 6, with a 0.887-fold (RR = 0.887, 95% CI: 0.842, 0.934) to 0.759-fold (RR = 0.759, 95% CI: 0.631, 0.913) decreased risk of breast cancer (P-nonlinearity = 0.880), but this association was not found in the population with premenopausal breast cancer (P-nonlinearity = 0.757). When stratified by age, among people younger than 10 years of age, an increase in somatotype was associated with a statistically significant reduction in breast cancer risk. From somatotype 3 to somatotype 6, the risk of breast cancer was reduced by 9.7-27.7% (P-nonlinearity = 0.175).
With early-life adiposity, our data support an inverse association with breast cancer risk, especially age less than 10 years and in postmenopausal women. Since girls with overweight likely remain overweight or even develop obesity in adulthood. While adults with overweight and obese are at increased risk of breast cancer and other types of cancer and various chronic diseases. Hence, we recommend that children should maintain a normal or slightly fat somatotype throughout all periods of life.