背景:重度抑郁症是精神疾病中最致残和最常见的诊断之一,目前全球患病率为一般人群的5-10%,终生高达20-25%。
背景:如今,常规治疗包括心理治疗和药物治疗;然而,超过60%的治疗患者反应不满意,在长期随访中,几乎五分之一的人对这些疗法无效。
■日益增长的社会能力和经济负担使医学界努力寻求更好的治疗方法,并发症少。各种非药理技术,如电惊厥疗法,迷走神经刺激,经颅磁刺激,病变手术,为此目的开发了深部脑刺激。
结论:我们回顾了20世纪初直到2009年7月的文献,并描述了这些方法的早期临床效果和主要报道的并发症。
BACKGROUND: Major depressive disorder is one of the most disabling and common diagnoses amongst psychiatric disorders, with a current worldwide prevalence of 5-10% of the general population and up to 20-25% for the lifetime period.
BACKGROUND: Nowadays, conventional treatment includes psychotherapy and pharmacotherapy; however, more than 60% of the treated patients respond unsatisfactorily, and almost one fifth becomes refractory to these therapies at long-term follow-up.
UNASSIGNED: Growing social incapacity and economic burdens make the medical community strive for better therapies, with fewer complications. Various nonpharmacological techniques like electroconvulsive therapy, vagus nerve stimulation, transcranial magnetic stimulation, lesion surgery, and deep brain stimulation have been developed for this purpose.
CONCLUSIONS: We reviewed the literature from the beginning of the twentieth century until July 2009 and described the early clinical effects and main reported complications of these methods.