Although high-intensity focused ultrasound (HIFU) has been applied widely in medicine, utilising its non-invasive dual ablation and thermal coagulation properties, its application in dentistry has primarily remained in the research phase, predominantly in in vitro studies. Nonetheless, there has been a consistent increase in the number of publications on this subject in recent decades, focusing on areas such as remineralisation of dentine surfaces, removal of smear layers, drug delivery, and microbial elimination. The number of advantages HIFU can offer, such as its non-surgical nature, absence of ionising radiation, lack of residue, and absence of aerosols, is driving this upward trend, indicating the potential for HIFU in clinical dentistry and ongoing efforts towards developing HIFU-based devices for routine dental use. This succinct review aims to outline the historical context, operational mechanisms of HIFU, summarise recent dental research, and provide a forward-looking perspective on the role of HIFU in modern clinical dentistry.

This study aimed to conduct a systematic review and critical analysis of the evidence pertaining to the efficacy of laser-activated irrigation (LAI) versus ultrasonic-activated irrigation (UAI) in mature permanent teeth. A comprehensive literature search was performed using PubMed and Google Scholar. Additionally, a hand search was performed to identify relevant studies related to UAI and LAI. The search covered all articles published from January 1997 to December 2021. The identified studies were screened for eligibility using the inclusion and exclusion criteria. The included articles were then subjected to data extraction and analysis. The search yielded 1,637 results. Of these, 23 articles were included in this systematic review. All included articles were assessed for the outcomes of antimicrobial efficacy, smear layer, and dentin debris removal. The majority of the articles reported the superiority of LAI over UAI. Within the confines of this systematic review, the current evidence mandates that LAI has superior efficacy over UAI in the elimination of microorganisms, dentin debris, and smear layer from the root canal system.