■COPD是由遗传和环境因素共同引起的呼吸系统疾病。多态性,作为遗传因素,能影响COPD的易感性。在这项研究中,我们在中国汉族人群中评估了3个基因多态性与COPD风险之间的关系.
■本研究共纳入376例诊断为COPD的患者和284例对照受试者。采用多因素logistic回归分析3个多态性(SMAD4rs10502913、IL-4rs2070874、HSPA1Lrs2227956)与COPD易感性的关系。
■与AA基因型相比,SMAD4rs10502913GG和AG基因型显着增加COPD风险(分别为校正OR=2.235,95%CI1.198-4.104;校正OR=2.218,95%CI1.204-4.151)。在分层分析中,GG基因型显著增加了60岁及以上(校正OR=2.519,95%CI1.266~5.015)和吸烟史少于30年的受试者的COPD风险(p=0.009;校正OR=3.751;95%CI1.398~10.062).这种增加的风险在GOLDI和GOLDII组中更为明显(校正OR=3.628,95%CI1.022-12.885;校正OR=2.394,95%CI1.004-5.710)。此外,AG基因型与60岁及以上受试者(校正OR=2.599,95%CI1.304-5.176)和吸烟者(p=0.021;校正OR=2.269;95%CI1.132-4.548)的COPD风险增加相关。这种增加的风险在GOLDIIICOPD组中更为明显(p=0.047;校正OR=2.532;95%CI1.012-6.336)。
■我们目前的研究表明SMAD4rs10502913基因型GG和AG与中国汉族人群COPD风险增加相关。需要对大规模人群进行进一步的验证研究来证实我们的发现。
UNASSIGNED: COPD is a respiratory disease caused by a combination of genetic and environmental factors. Polymorphism, as a genetic factor, can affect the susceptibility of the disease of COPD. In this study, we assessed the relationship between the polymorphisms of three genes and COPD risk in a Chinese Han population.
UNASSIGNED: A total of 376 patients diagnosed with COPD and 284 control subjects were enrolled in this study. Multivariate logistic regression analysis was used to analyze the association between three polymorphisms (SMAD4 rs10502913, IL-4 rs2070874, HSPA1L rs2227956) and COPD susceptibility.
UNASSIGNED: The SMAD4 rs10502913 GG and AG genotype significantly increased COPD risk (adjusted OR = 2.235, 95% CI 1.198-4.104; adjusted OR = 2.218, 95% CI 1.204-4.151, respectively) compared with the AA genotype. In the stratification analyses, the GG genotype significantly increased the risk of COPD in subjects aged 60 and over (adjusted OR = 2.519, 95% CI 1.266-5.015) and with a smoking history of less than 30 years (p=0.009; adjusted OR = 3.751; 95% CI 1.398-10.062). This increased risk was more pronounced in the group of GOLD I and GOLD II (adjusted OR = 3.628, 95% CI 1.022-12.885; adjusted OR = 2.394, 95% CI 1.004-5.710, respectively). In addition, AG genotype was associated with an increased COPD risk in subjects aged 60 and over (adjusted OR = 2.599, 95% CI 1.304-5.176) and in smokers (p=0.021; adjusted OR = 2.269; 95% CI 1.132-4.548). This increased risk was more obvious in the group of GOLD III COPD (p=0.047; adjusted OR = 2.532; 95% CI 1.012-6.336).
UNASSIGNED: Our present study indicated that the genotype GG and AG of SMAD4 rs10502913 are associated with an increased risk of COPD in a Chinese Han population. Further validation studies with large-scale populations are needed to confirm our findings.