背景:结节病是一种多系统肉芽肿性疾病,不仅影响皮肤,还可累及淋巴结,眼睛,还有肺.皮下结节病(SCS),是一种罕见的结节病,通常在40多岁和50多岁的女性中更为普遍,以皮下为特征,肉色结节,大多位于四肢。一项回顾性研究,以调查受SCS影响的患者的临床特征和对治疗的反应。
方法:2012年至2022年在我院门诊就诊的所有系统性和/或皮肤结节病患者。在这个群体中,临床特征,并对SCS患者的管理进行分析。
结果:在102例皮肤结节病特定病变患者中,有或没有系统参与,13例(13%)被诊断为SCS。
结论:我们的研究证实,正如预期的那样,SCS的系统参与是普遍的发现。此外,SCS患者预后相对较好,全身治疗与皮肤结节病的一线治疗没有区别。
BACKGROUND: Sarcoidosis is a multisystemic granulomatous disease which not only affect the skin but can also involve the lymph nodes, eyes, and lungs. Subcutaneous sarcoidosis (SCS), is a rare form of sarcoidosis which is generally more prevalent in women in their 40s and 50s, characterized by subcutaneous, flesh-colored nodules, mostly localized on the limbs. A retrospective study to investigate clinical features and response to treatment in patients affected by SCS.
METHODS: All patients with systemic and/or cutaneous sarcoidosis visited in our clinic hospital between 2012 and 2022. Out of this group, clinical features, and management of SCS patients were analyzed.
RESULTS: Out of 102 patients with specific lesions of cutaneous sarcoidosis, with or without systemic involvement, 13 (13%) were diagnosed with SCS.
CONCLUSIONS: Our study confirms that systemic involvement in SCS is the prevalent finding as expected. Moreover, SCS patients have a relatively good prognosis, and systemic treatment does not differ from first-line therapies for cutaneous sarcoidosis.