背景:烧蚀分数CO2激光被广泛用于解决各种皮肤问题,但治疗通常会导致不良反应,如红斑,色素沉着,和延长的恢复期,对患者生活质量产生负面影响。
目的:本研究旨在评估含CEFerulic血清和白藜芦醇BE夜间血清的局部护肤方案在中国人群中的疗效和安全性。
方法:在本随机分组中,调查员失明,分割面,对照试验,接受消融性CO2激光治疗的年龄在18-65岁的个体被随机分配到面部的任一侧应用CEFerulic加白藜芦醇BE血清(CEF-RBE),另一侧应用生理盐水(NS),连续14天。主要终点是第14天的红斑指数(EI),关键次要终点包括结痂脱离时间,EI和黑色素指数(MI)的百分比变化,皮肤水合作用,经皮水分流失,皮肤皮脂含量,水肿,和整体主题满意度。
结果:该研究包括51名患者,其中29人(56.9%)为女性,平均(SD)年龄为29.8(5.39)岁。在第14天,CEF-RBE侧的EI显着低于NS侧(308.9vs.325.3,p=0.034)。CEF-RBE侧完全结痂脱离的中位数(IQR)时间(天)为6.0(5.0-8.0),而NS侧为6.5(5.0-9.0)(p=0.018)。此外,CEF-RBE侧显示MI从基线到第14天下降7.4%,而NS侧增加0.2%(Δ=-7.6%,p=0.044)。在整个14天的随访中,CEF-RBE侧始终显示出比NS侧更高的皮肤水合作用。
结论:该研究强调了激光治疗后结合CEF-RBE在减少红斑和色素沉着方面的益处,促进伤口愈合,保持皮肤水合,尽管应考虑污染和依从性等限制。
BACKGROUND: Ablative fractional CO2 laser is widely used to address various skin problems, but the treatment often leads to adverse effects such as erythema, dyspigmentation, and extended recovery periods, negatively impacting patients\' quality of life.
OBJECTIVE: This
study aimed to evaluate the efficacy and safety of a topical skincare regimen containing both CE Ferulic serum and Resveratrol BE night serum following fractional CO2 laser treatment in Chinese population.
METHODS: In this randomized, investigator-blinded, split-face, controlled
trial, individuals aged 18-65 undergoing ablative CO2 laser treatment were randomly assigned to apply CE Ferulic plus resveratrol BE serum (CEF-RBE) to either side of face and normal saline (NS) to the other, for 14 consecutive days. The primary endpoint was erythema index (EI) on day 14, with key secondary endpoints including scabbing detachment time, percentage changes in EI and melanin index (MI), skin hydration, transepidermal water loss, skin sebum content, oedema, and overall subject satisfaction.
RESULTS: The
study included 51 patients, of whom 29 (56.9%) were female, with a mean (SD) age of 29.8 (5.39) years. On day 14, the CEF-RBE side exhibited significantly lower EI than the NS side (308.9 vs. 325.3, p = 0.034). The median (IQR) time (days) for complete scabbing detachment at the CEF-RBE side was 6.0 (5.0-8.0) compared to 6.5 (5.0-9.0) at NS side (p = 0.018). Additionally, the CEF-RBE side showed a 7.4% decrease in MI from baseline to day 14, while the NS side experienced a 0.2% increase (Δ = -7.6%, p = 0.044). Throughout the 14-day follow-up, the CEF-RBE side consistently displayed higher skin hydration than the NS side.
CONCLUSIONS: The
study highlighted the benefits of incorporating CEF-RBE following laser treatment in reducing erythema and hyperpigmentation, promoting wound healing, and maintaining skin hydration, although limitations such as contamination and adherence issues should be considered.