背景:道路交通伤害(RTI)是全球最重要的问题之一。一些研究报告说,感染嗜神经寄生虫弓形虫(T。gondii)增加了车祸的风险。在这项研究中,我们的目的是调查潜在弓形虫之间可能的关联,巨细胞病毒(CMV),和单纯疱疹病毒(HSV)感染在Jahrom(法尔斯省)有摩托车事故的风险,这是伊朗摩托车事故率很高的县。
方法:在病例对照研究的背景下;176名摩托车手,包括88名摩托车事故幸存者和88名没有事故的摩托车手,被认为是病例组和对照组,分别。弓形虫潜伏感染率,CMV,和HSV通过酶联免疫吸附测定(ELISA)进行评估。
结果:病例组88例中有11例(12.5%),对照组88例中有22例(25.0%)抗T。刚地IgG抗体,差异有统计学意义(OR=0.42;CI:0.19-0.95,p=0.03).CMV的一般血清阳性率(病例组中94.3%与对照组87.5%,OR=2.37;CI:0.78-7.13,p=0.12)和HSV(病例组的63.6%与对照组62.5%,OR=1.05;CI:0.57-1.94,p=0.87)在病例组和对照组之间没有显着差异。
结论:尽管在最近的报告中潜伏性弓形虫病与交通事故有关,我们发现,在这些事故的幸存者中,潜在弓形虫病和摩托车事故之间呈负相关。因此,与对照组相比,潜伏性CMV和HSV感染在病例之间没有显着差异。
BACKGROUND: Road traffic injuries (RTIs) are among the most important issues worldwide. Several studies reported that infection with the neurotropic parasite Toxoplasma gondii (T. gondii) increased the risk of car accidents. In this study, our objective was to investigate the possible associations among latent T. gondii, Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV) infections with the risk of motorcycle accidents in Jahrom (Fars Province), which is a county with a high rate of motorcycle accidents in Iran.
METHODS: In the setting of a
case-control study; 176 motorcyclist men, including 88 survivors of motorcycle accidents and 88 motorcyclist without accidents, were considered as case and control groups, respectively. Rates of latent infections with T. gondii, CMV, and HSV were assessed by an enzyme-linked immunosorbent assay (ELISA).
RESULTS: Eleven of 88 (12.5%) in the case group and 22 of 88 (25.0%) in controls were positive for anti-T. gondii IgG antibodies, this difference was statistically significant (OR = 0.42; CI: 0.19-0.95, p = 0.03). The general seroprevalence of CMV (94.3% in the
case group vs. 87.5% in the control group, OR = 2.37; CI: 0.78-7.13, p = 0.12) and HSV (63.6% in the
case group vs. 62.5% in the control group, OR = 1.05; CI: 0.57-1.94, p = 0.87) were not significantly different between the
case and control groups.
CONCLUSIONS: Although latent toxoplasmosis has been associated with traffic accidents in recent
reports, we found a negative association between latent toxoplasmosis and motorcycle accidents among survivors of these accidents. As such, latent CMV and HSV infections did not differ significantly between the cases compared to the control groups.