背景:皮质性耳聋是一种罕见的由脑听觉网络损伤引起的听觉功能障碍。目的是报告内在听觉中功能连通性的改变,电机,皮质性耳聋患者的感觉网络。
■一名41岁的女性患有右侧的肠外出血。八年前,她遭受了左卵黄出血,并有轻微的后遗症。她有四肢瘫痪,不平衡,感觉减退,和完全的听力损失。
■她被诊断为皮质性耳聋。六个月后,进行静息态功能磁共振成像(rs-fMRI)和弥散张量成像(DTI).DTI显示,使用确定性跟踪方法,当皮质脊髓束和体感轨迹完好无损时,声辐射被破坏。此外,患者显示听觉和感觉运动网络之间的功能连通性下降.
方法:患者接受2个月的住院卒中康复治疗。
结果:步态功能和日常生活活动能力得到改善。然而,完全性听力障碍在双侧型出血性卒中后6个月内持续存在.
结论:我们的病例报告似乎表明,听觉和感觉运动网络中自发神经元活动的功能改变与皮质性耳聋患者的运动和感觉障碍有关。
BACKGROUND: Cortical deafness is a rare auditory dysfunction caused by damage to brain auditory networks. The aim was to report alterations of functional connectivity in intrinsic auditory, motor, and sensory networks in a cortical deafness patient.
METHODS: A 41-year-old woman suffered a right putaminal hemorrhage. Eight years earlier, she had suffered a left putaminal hemorrhage and had minimal sequelae. She had quadriparesis, imbalance, hypoesthesia, and complete hearing loss.
METHODS: She was diagnosed with cortical deafness. After 6 months, resting-state functional magnetic resonance imaging (rs-fMRI) and diffuse tensor imaging (DTI) were performed. DTI revealed that the acoustic radiation was disrupted while the corticospinal tract and somatosensory track were intact using deterministic tracking methods. Furthermore, the patient showed decreased functional connectivity between auditory and sensorimotor networks.
METHODS: The patient underwent in-patient stroke rehabilitation therapy for 2 months.
RESULTS: Gait function and ability for activities of daily living were improved. However, complete hearing impairment persisted in 6 months after bilateral putaminal hemorrhagic stroke.
CONCLUSIONS: Our
case report seems to suggest that functional alterations of spontaneous neuronal activity in auditory and sensorimotor networks are related to motor and sensory impairments in a patient with cortical deafness.