Self-injurious behavior

自我伤害行为
  • 文章类型: Journal Article
    少女怀孕仍然是全球范围内重大的全球公共卫生问题。然而,它在发达国家呈现出复杂的现象,对母亲和儿童都有潜在的短期和长期后果。
    这项混合方法研究使用了法国横断面研究“青少年肖像”的数据,其中包括6000名年龄在13至17岁之间的女孩。定量方法包括将有怀孕史的亚组与同龄人进行比较,检查他们的生活经验和心理健康。定性方法调查了“青少年对您意味着什么?”这个问题,特别是针对报告有怀孕史的女孩。
    青少年怀孕的心理健康障碍发生率升高,包括黑暗的想法,抑郁症,自我伤害,参加危险的游戏,试图自杀和增加使用精神活性物质。在有限的支持下,与他们的同龄人相比。定性方法揭示了三个主要主题:“在行动中”,\“一种感觉\”,和“关系质量”。
    这个脆弱的青少年亚组表明,需要采取协调的多学科医疗保健方法,鉴于他们有限的父母和朋友支持,患有精神健康状况不佳的高风险。此外,这些发现描绘了一个“沉默的患者”人群,其特征是由于表达情绪困扰的困难而难以识别或管理情绪。
    UNASSIGNED: Teenage pregnancy remains a significant global public health concern worldwide. However, it presents a complex phenomenon in developed countries, carrying potential short- and long-term consequences for both mothers and children.
    UNASSIGNED: This mixed method study used data from the French cross-sectional study \"Portraits of adolescents\", which included 6000 girls aged between 13 and 17 years. The quantitative approach involved comparisons between a subgroup with an history of pregnancy and their peers, examining their lived-experience and mental health. The qualitative approach investigated the question \"What does being a teenager mean for you?\" specifically for the girls who reported an history of pregnancy.
    UNASSIGNED: Teenage pregnancies presented elevated rates of mental health disorders, including dark thoughts, depression, self-harm, participating in dangerous games, attempting suicide and increased use of psychoactive substances. With limited support, in comparison to their peers. The qualitative approach revealed three major themes: \"being in action\", \"a way of feeling\", and \"quality of relationship\".
    UNASSIGNED: This vulnerable subgroup of adolescents suggests the need for a coordinated multidisciplinary healthcare approach, given their limited parental and friend support, with a high risk of experiencing poor mental health. Additionally, these findings portray a \"silent sufferer\" population characterized by difficulties recognizing or managing emotions due to difficulties in expressing their emotional distress.
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  • 文章类型: Journal Article
    背景:故意身体自我伤害(IPSI)是一项紧迫的健康挑战,对伤害模式的认识很少,管理和结果。本研究调查了奥克兰一家主要医院的IPSI流行病学和临床方面,突出人口统计,损伤模式及其对临床实践和预防的启示。
    方法:使用奥克兰市医院创伤登记数据,回顾,对2015年1月至2019年12月收治的成年患者进行了描述性研究.它评估了人口统计特征,损伤模式和结果,使用Mann-WhitneyU测试,费舍尔精确检验和卡方检验。
    结果:在137个IPSI录取中,92(67%)需要手术,24%出现术后并发症。在39例(28.5%)入院中发现了严重的创伤。排放目的地各不相同,只有64名(47%)患者在没有帮助的情况下返回家中。不同性别的伤害严重程度没有显著差异,年龄或受伤事件地点。重大伤害通常是由于跌倒(39个中的19个)和撕裂/刺伤造成的轻伤(98个中的73个)。
    结论:IPSI对奥克兰卫生服务构成了重大挑战,有明显的护理负担。该研究强调需要有针对性的干预措施来降低IPSI的发生率并改善预后。它强调了多学科护理方法的重要性,整合外科,心理健康和康复服务。
    BACKGROUND: Intentional physical self-injury (IPSI) is a pressing health challenge and there is little awareness of injury patterns, management and outcomes. This study examines IPSI\'s epidemiological and clinical aspects in one major Auckland hospital, highlighting demography, injury patterns and implications for clinical practice and prevention.
    METHODS: Using Auckland City Hospital Trauma Registry data, a retrospective, descriptive study was conducted covering adult patients admitted from January 2015 to December 2019. It assessed demographic characteristics, injury patterns and outcomes, using Mann-Whitney U tests, Fisher\'s exact tests and Chi-squared tests.
    RESULTS: Among 137 IPSI admissions, 92 (67%) required surgery, and 24% experienced post-operative complications. Major trauma was identified in 39 (28.5%) admissions. Discharge destinations varied, with only 64 (47%) patients returning home unassisted. Injury severity did not significantly vary across sex, age or injury event location. Major injuries often resulted from falls (19 of 39) and minor injuries from lacerations/stabs (73 of 98).
    CONCLUSIONS: IPSI represents a significant challenge to Auckland health services, with a notable burden of care. The study highlights the need for targeted interventions to reduce the incidence of IPSI and improve outcomes. It underscores the importance of multidisciplinary approaches to care, integrating surgical, mental health and rehabilitative services.
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  • 文章类型: Journal Article
    目的:这项研究探讨了来自不同背景的年轻人的观点,有或没有自我伤害的历史,关于在线分享自我伤害图像的动机和影响,以及将他们的社交媒体数据用于心理健康研究。
    方法:对27次半结构化一对一访谈的主题分析。
    方法:2021年举办了两次研讨会。
    方法:我们招募了27名16-24岁的研究参与者(60%为男性)。16名(59%)参与者是难民和寻求庇护者(RAS)。
    结果:产生了两个主要主题:(1)自我伤害的在线图像捕获了共享此类图像的感知动机,对他人的潜在影响和可能的审查需要。这个主题的特点是对分享动机的混合态度,有些人认为这是寻求关注,而其他人则认为这是寻求或分享痛苦的帮助。总的来说,参与者一致认为,自我伤害的图像可以触发,并应包括触发警告。(2)心理健康和自我伤害研究的数据共享捕获了使用社交媒体帖子和图像用于研究目的的观点,以及对公共和私营组织的信任水平。它概述了他们分享数据以进行公共利益研究的积极看法,但强调了同意的问题。持有和进行研究的两个最值得信赖的组织是国家卫生服务和大学。RAS组的参与者更倾向于同意使用他们的数据,并且对政府的信任度更高。
    结论:年轻人关心他们的隐私和使用他们的数据,即使这些数据是公开的。需要与年轻人共同制作资源,以支持理解和开发创新解决方案,以获得知情同意,以共享和研究公共利益。来自被排斥社区的年轻人,移民后RAS和男性应该有目的地参与未来的社交媒体研究。
    OBJECTIVE: This study explored the views of young people from diverse backgrounds, with or without a history of self-harm, on the motivation and impacts of sharing self-harm imagery online and the use of their social media data for mental health research.
    METHODS: Thematic analysis of 27 semi-structured one-to-one interviews.
    METHODS: Two workshops were conducted in 2021.
    METHODS: We recruited 27 study participants aged 16-24 (60% male). Sixteen (59%) participants were refugee and asylum seekers (RAS).
    RESULTS: Two main themes were generated: (1) Online imagery of self-harm captured perceived motivations for sharing such images, the potential impacts on others and possible need of censorship. This theme was characterised by mixed attitudes towards motivations for sharing, with some perceiving this as attention seeking, while others thought of it as help seeking or sharing of pain. Overall, participants agreed that images of self-harm can be triggering and should include trigger warnings. (2) Data sharing for mental health and self-harm research captured views on the use of social media posts and images for research purposes, and levels of trust in public and private organisations. It outlined positive views on their data being shared for research for public benefit, but highlighted issues of consent. The two most trusted organisations to hold and conduct research were the National Health Service and Universities. Participants from the RAS group were more inclined to agree to their data being used and had higher levels of trust in government.
    CONCLUSIONS: Young people care about their privacy and use of their data even when it is publicly available. Coproduction with young people of resources to support understanding and develop innovative solutions to gaining informed consent for data sharing and research for public benefit is required. Young people from excluded communities, post-immigration RAS and males should be purposively involved in future social media research.
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  • 文章类型: Journal Article
    背景:自我和异性恋暴力(SHDV)是一个严重的公共卫生问题,也是一个复杂的现象,受个人和环境因素的影响。SHDV可能特别发生在个人时刻,经济和/或社会危机。在COVID-19大流行期间,ISS-Helplines操作员已经意识到呼叫者的心理困扰和自我隔离的增加。ViolHelp项目旨在识别ISS-Helplines活动中出现的SHDV的潜在警告标志和风险因素(IstitutoSuperiorediSanità,ISS,意大利国家卫生研究所)。
    方法:开发了收集SHDV警告标志和风险因素的仪表板,用于在ISS-Helplines活动期间使用。
    结果:在一年的数据收集中,编译了135个电话。在106个电话中,来电者提到了经历过的暴力:72个自我指导的暴力(SDV),20异性恋暴力(HDV),14两者SDV最常见的警告信号和危险因素是死亡欲望(68.6%)。以前的自杀未遂(31.4%)和自残威胁(25.6%);对于HDV,情绪低落(32.4%),病理和/或精神疾病的诊断,渴望死亡,使用精神药物,和酗酒(29.4%)。
    结论:该试点项目的结果表明,能够阅读警告标志并创建一个可以改善信息的网络的重要性,为面临暴力风险的人及其家人开展预防和支持活动。
    BACKGROUND: Self- and hetero-directed violence (SHDV) is a serious public health problem and a complex phenomenon, influenced by individual and environmental factors. SHDV may occur particularly in moments of personal, economic and/or social crisis. During the COVID-19 pandemic, the ISS-Helplines operators have perceived an increase in psychological distress and self-isolation among callers. The ViolHelp project aimed at identifying potential warning signs and risk factors of SHDV emerging in the activity of the ISS-Helplines (Istituto Superiore di Sanità, ISS, Italian National Institute of Health).
    METHODS: A dashboard collecting warning signs and risk factors of SHDV was developed to be used during the ISS-Helplines activity.
    RESULTS: In one year of data collection, 135 calls were compiled. In 106 calls, callers referred experienced violence: 72 self-directed violence (SDV), 20 hetero-directed violence (HDV), 14 both. The most frequent warning signs and risk factors for SDV were desire to die (68.6%), previous suicide attempts (31.4%) and threat of self-harm (25.6%); for HDV were depressed mood (32.4%), diagnosis of pathology and/or psychiatric disorders, desire to die, use of psychotropic drugs, and alcohol abuse (29.4%).
    CONCLUSIONS: The results of this pilot project show the importance of being able to read the warning signs and to create a network that can improve information, prevention and support activities for people at risk of violence and their families.
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  • 文章类型: Journal Article
    我们旨在确定患者自身造成的肺损伤(P-SILI)相关气胸/纵隔气胸的临床特征,为了揭示其风险因素,并评估其对严重COVID-19病例的影响。总的来说,本病例对照研究包括229例患者。根据纳入和排除标准,将其随机分为病例组和对照组。进一步分析两组自发性气胸/纵隔气胸(SP/P)的危险因素。最后,分析病例组死亡的危险因素,并分析所有患者死亡与SP/P的关系.患者平均年龄为59.69±17.01岁,其中大多数是男性(74.2%),其中62.0%在入院时有合并症。呼吸频率高于30BPM是SP/P的危险因素(OR7.186,95%CI2.414-21.391,P<0.001)。早期应用HFNC或NIV导致延迟插管的患者出现SP/P时死亡率较高(P<0.05)。此外,高龄增加死亡风险(P<0.05)。最后,SP/P可能是重症COVID-19患者死亡的危险因素(OR2.047)。P-SILI发生于严重的COVID-19伴急性呼吸衰竭。有必要识别P-SILI的危险因素,严重P-SILI的指标,以及预防措施。
    We aimed to determine the clinical characteristics of patient self-inflicted lung injury (P-SILI)-associated pneumothorax/pneumomediastinum, to reveal its risk factors, and to assess its impact on severe COVID-19 cases. In total, 229 patients were included in this case-control study. They were randomly divided into either the case group or the control group as per the inclusion and exclusion criteria. The two groups were further analyzed to reveal the risk factors of spontaneous pneumothorax/pneumomediastinum (SP/P). Finally, risk factors for death were analyzed in the case group and the relationship between death and SP/P was also analyzed among all patients. The mean age of patients was 59.69 ± 17.01 years, most of them were male (74.2%), and 62.0% of them had comorbidities upon admission. A respiratory rate higher than 30 BPM was a risk factor for SP/P (OR 7.186, 95% CI 2.414-21.391, P < 0.001). Patients with delayed intubation due to early application of HFNC or NIV had a higher mortality rate when they developed SP/P (P < 0.05). Additionally, advanced age increased the risk of death (P < 0.05). Finally, SP/P may be a risk factor for death among patients with severe COVID-19 (OR 2.047). P-SILI occurs in severe COVID-19 with acute respiratory failure. It is necessary to identify the risk factors of P-SILI, the indicators of severe P-SILI, and the preventive measures.
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  • 文章类型: Journal Article
    目的:少数研究探讨了医院急诊科(ED)的自我伤害表现时间-一个可以确定患者是否接受心理健康评估的重要因素-主要集中在成人样本上。这项研究检查了对ED的自我伤害陈述的时间,使用的自我伤害方法,心理健康评估,以及不同年龄段的入院数据。
    方法:使用爱尔兰国家自我伤害登记处在13年时间框架(2007-2019年)内的数据,这项研究比较了时间,days,季节,自我伤害的方法,和儿童(8-12岁)的入院数据,青少年(13-17岁),年轻人(18-25岁)和成年人(>25岁)。
    结果:所有年龄段的152,474份自我伤害报告(78.6%)中的大多数发生在工作时间外(在标准工作时间或周一至周五09:00-17:00的工作时间之外)。午夜前四个小时,青少年(27.9%)和成年人(23.1%)的自我伤害表现比例最高,而午夜后4小时的年轻人出现自我伤害的比例最高(22.9%).午夜16:00的时间框架在儿童中出现自我伤害的比例最高(52.3%)。与年轻人的非工作时间相比,在工作时间内接受心理健康评估的患者比例更高(78.2%vs.73.3%)和成年人(76.1%vs.72.0%)。儿童和青少年在夏季的自我伤害表现最低。
    结论:医院应确保为出现自残的个人提供足够的资源,尤其是在过度拥挤的ED的情况下,和协议需要为那些表现出自我伤害由于中毒。符合国家政策,在非工作时间期间就诊的患者的协议应设计为可以纳入专职医疗多学科团队的服务,社会工作,成瘾服务和咨询组织。鉴于儿童和青少年在学校放假期间的自残率较低,必须在心理健康和自我伤害公共卫生预防干预措施的背景下考虑学校环境。
    OBJECTIVE: The few studies that have explored self-harm presentation times at hospital emergency departments (EDs) - an important factor that can determine if a patient receives a mental health assessment - primarily focus on adult samples. This study examined the times of self-harm presentations to EDs, self-harm methods used, mental health assessments, and admission data across different age-groups.
    METHODS: Using data from the National Self-Harm Registry Ireland over a 13-year timeframe (2007-2019), this study compared times, days, seasons, methods of self-harm, and admission data for children (8-12 years), adolescents (13-17 years), young adults (18-25 years) and adults (> 25 years).
    RESULTS: The majority of the 152,474 self-harm presentations (78.6%) for all ages occurred out-of-hours (outside the standard working hours or in-hours times of 09:00-17:00, Monday-Friday). The four hours before midnight had the highest proportions of self-harm presentations for adolescents (27.9%) and adults (23.1%), whereas the four hours after midnight had the highest proportion of self-harm presentations for young adults (22.9%). The 16:00-midnight timeframe had highest proportion of self-harm presentations in children (52.3%). Higher proportions of patients received a mental health assessment in-hours compared to out-of-hours among young adults (78.2% vs. 73.3%) and adults (76.1% vs. 72.0%). Self-harm presentations were lowest during summer months in children and adolescents.
    CONCLUSIONS: Hospitals should ensure that adequate resources are available for individuals presenting with self-harm, especially in the case of overcrowded EDs, and protocols need to be designed for those presenting with self-harm due to intoxication. In line with national policy, protocols for patients presenting during out-of-hours should be designed that can incorporate services from allied health multidisciplinary teams, social work, addiction services and counselling organisations. Given the lower rates of self-harm during school holidays for children and adolescents, the school environment must be considered in the context of mental health and self-harm public health prevention interventions.
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  • 文章类型: Journal Article
    目的:探讨医疗保健从业人员对老年人自残管理实践的看法。
    方法:对医疗保健从业人员进行了半结构化访谈,包括心理医生顾问,全科医生,临床心理学家,心理治疗师,临床护士专家和社会工作者。使用有目的的抽样来招募爱尔兰共和国的参与者,以确保包括医疗保健从业人员的不同观点。通过专业和临床研究网络招募了医疗保健从业人员的广告,社交媒体,和滚雪球方法。采访是录音的,逐字转录,并使用反身性主题分析法进行分析。
    结果:我们从2023年4月至7月对20名医疗保健从业人员进行了采访。产生了三个主要主题:第一,认为自杀的风险更大,并提高了对老年人自我伤害表现复杂性的认识。第二,综合护理是改善老年人自我伤害管理的途径。第三,安全规划在老年人风险评估中的重要性。
    结论:医疗从业者认为老年人的自我伤害是复杂的,具有挑战性,与高自杀风险有关,照顾和谨慎的患者。确定了相关医疗保健从业人员之间对综合支持和改进协作的需求。建议初级保健在自我伤害后识别和管理老年人中起主导作用。在这个年龄段,加强心理健康促进和对心理健康和自我伤害的认识将有助于解决当前的耻辱和耻辱。
    OBJECTIVE: To explore healthcare practitioners\' views on management practices of self-harm in older adults.
    METHODS: Semi-structured interviews were conducted with healthcare practitioners, including consultant psychiatrists, general practitioners, clinical psychologists, psychotherapists, clinical nurse specialists and social workers. Purposeful sampling was used to recruit participants in the Republic of Ireland ensuring diverse perspectives of healthcare practitioners were included. Healthcare practitioners were recruited advertising via professional and clinical research networks, social media, and snowballing methods. Interviews were audio-recorded, transcribed verbatim, and analysed using reflexive thematic analysis.
    RESULTS: We conducted interviews with 20 healthcare practitioners from April to July 2023. Three main themes were generated: first, a perceived greater risk of suicide, and increased awareness of complexity in older adults\' self-harm presentations. Second, integrated care as an avenue for improving the management of self-harm in older adults. Third, the importance of safety planning in risk assessments of older adults.
    CONCLUSIONS: Healthcare practitioners viewed self-harm in older adults as complex, challenging, and associated with high suicide risk, approaching patients with care and caution. The need for integrated support and improved collaboration between relevant healthcare practitioners was identified. Suggestions were made for primary care having a lead role in identifying and managing older adults after self-harm. Increased mental health promotion and awareness of mental health and self-harm in this age group would help address current stigma and shame.
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  • 文章类型: Journal Article
    背景:对于反复自我伤害的严重心理健康问题青少年,自我伤害预防应用程序的社会有效性知之甚少。
    目的:我们评估了可接受性,BlueIce的使用和安全,一个自我伤害预防应用程序的青少年自我伤害。
    方法:混合方法研究涉及使用后访谈的内容分析。参与者是一个由60名12-17岁的英国青少年组成的临床小组,这些青少年反复自我伤害,随机接收BlueIce。
    结果:在考虑自我伤害时,57/60(95%)的受访者使用BlueIce,47/57(82%)的受访者使用BlueIce。17/47(36%)正在考虑自我伤害的人使用了六次以上,其中36/47(77%)报告说BlueIce防止了至少一次自我伤害。33/47(70%)报告了他们使用该应用程序的情况,但仍继续自我伤害。该应用程序未使用或没有帮助的原因包括感到太苦恼,消极的心态,事先决定自残或遗忘。BlueIce在5颗星中被评为4.09(SD=0.75),对于易用性(8.70,SD=1.37)和可接受性(7.68,SD=2.05)和有用性(6.77,SD=1.72),平均评分高,为10。没有受访者认为BlueIce会引发任何自残事件。
    结论:这些发现与以前的评估一致,突出了可接受性。BlueIce的使用和安全。自我报告表明,BlueIce可以防止某些自我伤害事件。
    结论:我们的结果强调了BlueIce自我伤害应用程序对反复自我伤害的青少年的可接受性。
    BACKGROUND: Little is known about the social validity of self-harm prevention apps for young adolescents with severe mental health problems who repeatedly self-harm.
    OBJECTIVE: We assessed the acceptability, use and safety of BlueIce, a self-harm prevention app for young adolescents who self-harm.
    METHODS: Mixed methods study involving a content analysis of postuse interviews. Participants were a clinical group of 60 UK adolescents aged 12-17 with repeated self-harm, randomised to receive BlueIce.
    RESULTS: BlueIce was used by 57/60 (95%) respondents with 47/57 (82%) using BlueIce when thinking about self-harm. 17/47 (36%) who were thinking about self-harm used it on more than six occasions with 36/47 (77%) reporting that BlueIce prevented at least one episode of self-harm. 33/47 (70%) reported occasions when they used the app but still went on to self-harm. Reasons why the app was not used or not helpful included feeling too distressed, a negative mindset, prior decision to self-harm or forgetting. BlueIce was rated 4.09 (SD=0.75) out of 5 stars, with high mean ratings out of 10 for ease of use (8.70, SD=1.37) and good for acceptability (7.68, SD=2.05) and helpfulness (6.77, SD=1.72). No respondent identified BlueIce as triggering any episode of self-harm.
    CONCLUSIONS: These findings are consistent with previous evaluations and highlight the acceptability, use and safety of BlueIce. Self-reports indicate that BlueIce prevented some episodes of self-harm.
    CONCLUSIONS: Our results highlight the acceptability of the BlueIce self-harm app for young adolescents who repeatedly self-harm.
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  • 文章类型: Journal Article
    背景:自我伤害是一项重要的公共卫生挑战。它对急诊科(ED)服务的使用以及患者和家人的医疗费用造成了显着负担。医疗补助系统对于为与医疗费用作斗争的个人提供财务支持至关重要。这项研究探讨了医疗补助覆盖与自我伤害事件后急诊就诊的关系,利用韩国全国的ED监测数据。
    方法:所有年龄在14岁以上的患者的数据,这些患者在发生自残事件后出现在ED中,而不管是否打算结束生命,包括自我中毒的病例,是从国家ED信息系统(NEDIS)收集的。计算了各省每10万人的年度自残访视率(SHVR),并进行了广义线性模型分析,以SHVR为因变量,与医疗补助覆盖率相关的因素为自变量。
    结果:医疗补助入学率增加1%与SHVR显着下降14%有关。每增加1,000韩元的医疗补助支出与SHVR减少1%相关。然而,每位参保人的Medicaid访视次数的增加和Medicaid承保天数的延长与SHVR的增加相关.与老年人群相比,SHVR与青少年和年轻人的医疗补助覆盖率参数具有更强的相关性。
    结论:扩大医疗补助覆盖范围,并仔细监测医疗补助利用模式的变化,可以通过减少与自我伤害相关的就诊来减轻ED过载。
    BACKGROUND: Self-harm presents an important public health challenge. It imposes a notable burden on the utilization of emergency department (ED) services and medical expenses from patients and family. The Medicaid system is vital in providing financial support for individuals who struggle with medical expenses. This study explored the association of Medicaid coverage with ED visits following incidents of self-harm, utilizing nationwide ED surveillance data in Korea.
    METHODS: Data of all patients older than 14 years who presented to EDs following incidents of self-harm irrespective of intention to end their life, including cases of self-poisoning, were gathered from the National ED Information System (NEDIS). The annual self-harm visit rate (SHVR) per 100,000 people was calculated for each province and a generalized linear model analysis was conducted, with SHVR as a dependent variable and factors related to Medicaid coverage as independent variables.
    RESULTS: A 1% increase in Medicaid enrollment rate was linked to a significant decrease of 14% in SHVR. Each additional 1,000 Korean Won of Medicaid spending per enrollee was correlated with a 1% reduction in SHVR. However, an increase in Medicaid visits per enrollee and an extension of Medicaid coverage days were associated with an increase in SHVR. SHVR exhibited a stronger associated with parameters of Medicaid coverage in adolescents and young adults than in older adult population.
    CONCLUSIONS: Expansion of Medicaid coverage coupled with careful monitoring of shifts in Medicaid utilization patterns can mitigate ED overloading by reducing visits related to self-harm.
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  • 文章类型: Journal Article
    在临床实践中,准确识别青少年重度抑郁障碍(MDD)患者的自我伤害行为对于个体化治疗至关重要.这项研究旨在使用功能性近红外光谱(fNIRS)对患有MDD和自我伤害(SH)的青少年进行言语流畅性任务(VFT)评估与没有SH的青少年相比,检查前额叶皮层激活的差异。共纳入60名符合条件的患者进行最终分析,SH组有36名参与者,非SH组有24名参与者。我们发现,在VFT评估期间,SH组的右中额回(rMFG)比非SH组的激活程度更高(z=-3.591,p=0.004,FDR校正)。rMFG的β值的z得分与曲线下面积(AUC)在区分两组时表现出良好的辨别能力(AUC=0.775,p<0.001)。这些发现表明,fNIRS-VFT范式可能是发现患有MDD的青少年之间神经生物学差异的有用工具。
    In clinical practice, accurately identifying self-injurious behavior among adolescents with major depressive disorder (MDD) is crucial for individualized treatment. This study aimed to examine the differences in prefrontal cortex activation using the functional near-infrared spectroscopy (fNIRS) during the verbal fluency task (VFT) assessment of adolescents with MDD and self-harm (SH) compared with those without SH. A total of 60 eligible patients were included for final analysis, with the SH group containing 36 participants, and the Non-SH group containing 24 participants. We found that right middle frontal gyrus (rMFG) was more activated in the SH group than that in the Non-SH group during the VFT assessments (z = -3.591, p = 0.004, FDR correction). The z-scores of beta values of rMFG exhibited a good discriminatory power with the area under the curve (AUC) in distinguishing the two groups (AUC = 0.775, p < 0.001). These findings reveal that the fNIRS-VFT paradigm may be a useful tool for discovering neurobiological differences among adolescents with MDD.
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