SMARCB1(INI1)缺陷型鼻腔鼻窦癌是最近公认的具有广泛组织形态学谱的实体。鼻窦腺癌(SNAC)的分类是复杂的,还有待重新定义,尤其是高等级的非肠道型SNAC。最近,已经报道了SMARCB1(INI1)缺陷的SNACs具有独特的肿瘤细胞样/横纹肌样细胞形态和不同程度的腺体形成。在这里,我们描述了SMARCB1(INI1)缺陷型SNAC的罕见病例,该病例主要由具有混合固体和筛状模式的肿瘤细胞样/横纹肌样细胞组成。该病例最初被诊断为非肠道型SNAC,并通过免疫组织化学(IHC)由于SMARCB1(INI1)的完全缺失表达而被重新分类。SMARCB1(INI1)染色剂为鉴定这种特定类型的SNAC提供了有价值的工具。我们将此病例与我们部门诊断的其他SNAC进行了比较,并回顾了有关该特定类型SNAC的相关文献。
SMARCB1(INI1)-deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. The classification of sinonasal adenocarcinoma (SNAC) is complex and yet to be redefined, especially the category of high-grade non-intestinal-type SNAC. Recently SMARCB1(INI1)-deficient SNACs with an unique oncocytoid/rhabdoid cytomorphology and variable degrees of glandular formation have been reported. Here we described a rare
case of SMARCB1(INI1)-deficient SNAC composed of mainly oncocytoid/rhabdoid cells with mixed solid and cribriform patterns. This
case was originally diagnosed as non-intestinal-type SNAC and was reclassified due to complete loss expression of SMARCB1(INI1) by immunohistochemistry (IHC). The SMARCB1(INI1) stain provides a valuable tool for identification of this specific type of SNAC. We compared this
case with other SNACs diagnosed in our department and reviewed relevant literature for this specific type of SNAC.