创新疫苗产品对于帮助解决阻碍实现麻疹和风疹(MR)疫苗覆盖目标的现有实施障碍至关重要。克服这些障碍是实现“2030年免疫议程”目标的必要条件。微阵列补丁(MAP),一种创新的无针输送装置目前正在临床开发中,可以在这方面改变游戏规则,并有助于在低收入和中等收入国家公平地提供疫苗以及大流行的防范和应对。深入了解MRMAP的最理想和最有影响力的用途,可以证明对识别目标产品概况的关键属性至关重要。告知政策和收养决定,并帮助评估这项技术的潜在公共卫生和经济价值。此过程的第一步是定义MR-MAP的潜在用例,即,该产品最有可能在免疫计划中使用的地点和方式。
■通过应用基于设计的以用户为中心的方法,我们实施了一个三步的过程,包括案头审查,一项调查,和采访,为MRMAPS定义最相关的用例。
■六个用例已被确定为与所有不同国家和免疫计划设计相关,并由专家验证。
■确定的用例已经为MR-MAP的需求估计提供了信息,并为开发初始的完整疫苗价值评估奠定了基础。我们相信,在未来,它们将非常有价值,以确保这种有前途的创新的设计方式最大化影响,特别是在最需要的人口和国家。
Innovative vaccine products will be critical in helping to address the existing implementation barriers that have prevented the achievement of the measles and
rubella (MR) vaccine coverage targets. Overcoming those barriers will be necessary to achieve the \"Immunization Agenda 2030\" goals. Microarray patches (MAPs), an innovative needle-free delivery device currently in clinical development, can be a potential game changer in this respect and contribute to the equitable delivery of vaccines in low- and middle-income countries and pandemic preparedness and response. Developing in-depth knowledge of the most desired and impactful uses of MRMAPs can prove critical to identifying the critical attributes of the target product profile, informing policy and adoption decisions, and helping to evaluate the potential public health and economic value of this technology. The first step in this process is the definition of the potential use cases for MR-MAPs, i.e., where and how this product is most likely to be used within the immunization programme.
By applying a design-based user-centric approach, we implemented a three-step process, including a desk review, a survey, and interviews, to define the most relevant use cases for MR MAPS.
Six use cases have been identified as relevant across all different countries and immunization programme designs and validated by experts.
The identified use cases have already informed the demand estimate for MR-MAPs and provided the foundation for developing an initial full vaccine value assessment. We believe that, in the future, they will be highly valuable in ensuring that the roll-out of this promising innovation is designed in a way that maximizes the impact, particularly in populations and countries that are most in need.