背景:核黄素(维生素B2)是一种水溶性微量营养素,被认为是核苷酸黄素腺嘌呤二核苷酸和黄素单核苷酸的前体。这种维生素构成线粒体复合物,并作为酶辅助因子参与与能量代谢相关的几种机制。
目的:本系统综述收集并讨论了关于核黄素在脂质能量代谢中的作用的最相关结果,蛋白质,和碳水化合物。
方法:在PubMed-Medline中进行了系统搜索,Scopus,Embase,和使用PICOS(人口,干预,比较,结果,研究设计)策略。
方法:按照预定的合格标准,筛选研究经历了两个阶段。提取的信息涵盖了参考细节,研究设计,人口特征,实验模型,治疗参数和剂量,给药途径,治疗持续时间,和结果发现。
方法:使用用于体内研究的SYRCLE偏差风险(RoB)工具和适用于体外研究的QUIN工具评估偏差风险,利用10个领域,包括选择偏差,性能偏差,检测偏差,减员偏差,报告偏见,和其他偏见,评价纳入研究的方法学质量。
结论:这篇综述得出结论,核黄素通过激活初级代谢途径调节能量代谢,并参与能量平衡稳态。
BACKGROUND: Riboflavin (vitamin B2) is a water-soluble micronutrient considered to be a precursor of the nucleotides flavin adenine dinucleotide and flavin mononucleotide. This vitamin makes up mitochondrial complexes and participates as an enzymatic cofactor in several mechanisms associated with energy metabolism.
OBJECTIVE: This systematic
review collected and discussed the most relevant results on the role of
riboflavin in the energy metabolism of lipids, proteins, and carbohydrates.
METHODS: A systematic search was carried out in the PubMed-Medline, Scopus, Embase, and Web of Science databases using the PICOS (Population, Intervention, Comparison, Outcome, Study design) strategy.
METHODS: The screening of studies went through 2 stages following predefined eligibility criteria. The information extracted covered reference details, study design, population characteristics, experimental model, treatment parameters and dosage, route of administration, duration of treatment, and results found.
METHODS: The risk of bias was assessed using the SYRCLE Risk of Bias (RoB) tool for in vivo studies and the QUIN tool adapted for in vitro studies, utilizing 10 domains, including selection bias, performance bias, detection bias, attrition bias, reporting bias, and other biases, to evaluate the methodological quality of the included studies.
CONCLUSIONS: This
review concludes that
riboflavin regulates energy metabolism by activating primary metabolic pathways and is involved in energy balance homeostasis.