PDF(Pubmed)
Abstract：
OBJECTIVE: The objective of the current study is to compare the treatment effects of different vitamins on essential hypertension to provide an initial basis for developing evidence-based practices.
METHODS: Systematic review and network meta-analysis.
METHODS: Five electronic databases (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched from their inception to 25 September 2023.
RESULTS: The primary outcomes were the difference between the intervention group and the control group in changes in office systolic blood pressure (SBP) and office diastolic blood pressure (DBP) from baseline. The secondary outcomes were the difference between the intervention group and the control group in changes in 24-hour mean ambulatory systolic blood pressure (24 hours SBP), 24-hour mean ambulatory diastolic blood pressure (24 hours DBP) and heart rate (HR) from baseline.
RESULTS: A total of 23 studies comparing five vitamins (vitamin B2, vitamin C, vitamin D, vitamin E, folic acid) and involving 2218 participants were included. The included trials were all vitamin versus placebo, so the network was star-shaped. Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo. In addition, no evidence was found that any of the five vitamins influenced DBP, 24 hours SBP, 24 hours DBP, or HR. The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity. Sensitivity and subgroup analysis revealed that the effect of vitamin intervention on blood pressure varies according to different doses of vitamins.
CONCLUSIONS: According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
UNASSIGNED: CRD42022352332.
METHODS: Systematic review and network meta-analysis.
METHODS: Five electronic databases (PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov) were searched from their inception to 25 September 2023.
RESULTS: The primary outcomes were the difference between the intervention group and the control group in changes in office systolic blood pressure (SBP) and office diastolic blood pressure (DBP) from baseline. The secondary outcomes were the difference between the intervention group and the control group in changes in 24-hour mean ambulatory systolic blood pressure (24 hours SBP), 24-hour mean ambulatory diastolic blood pressure (24 hours DBP) and heart rate (HR) from baseline.
RESULTS: A total of 23 studies comparing five vitamins (vitamin B2, vitamin C, vitamin D, vitamin E, folic acid) and involving 2218 participants were included. The included trials were all vitamin versus placebo, so the network was star-shaped. Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo. In addition, no evidence was found that any of the five vitamins influenced DBP, 24 hours SBP, 24 hours DBP, or HR. The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity. Sensitivity and subgroup analysis revealed that the effect of vitamin intervention on blood pressure varies according to different doses of vitamins.
CONCLUSIONS: According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
UNASSIGNED: CRD42022352332.
摘要：
目的：本研究的目的是比较不同维生素对原发性高血压的治疗效果，为制定循证实践提供初步依据。
方法：系统评价和网络荟萃分析。
方法：五个电子数据库(PubMed，Embase,WebofScience,Cochrane中央受控试验和ClinicalTrials.gov）从开始到2023年9月25日进行了搜索。
结果：主要结局是干预组和对照组在办公室收缩压（SBP）和办公室舒张压（DBP）相对于基线的变化方面的差异。次要结局是干预组和对照组的24小时平均动态收缩压（24小时SBP）变化的差异，基线的24小时平均动态舒张压(24小时DBP)和心率(HR)。
结果：共有23项研究比较了五种维生素（维生素B2，维生素C，维生素D,维生素E,叶酸），并包括2218名参与者。纳入的试验都是维生素和安慰剂，所以网络是星形的。在五种维生素中，只有维生素E在降低SBP方面显着更有效（平均差异：-14.14mmHg，95%可信区间：-27.62至-0.88）比安慰剂。此外,没有证据表明五种维生素中的任何一种都会影响DBP，24小时SBP,24小时DBP,或HR。维生素的剂量，地理区域和男性百分比(仅SBP)可能是异质性的来源。敏感性和亚组分析显示，维生素干预对血压的影响因维生素剂量的不同而异。
结论：根据结果，维生素E可能是降低SBP的有效措施，但需要更多的研究来验证这一发现。
■CRD42022352332。
方法：系统评价和网络荟萃分析。
方法：五个电子数据库(PubMed，Embase,WebofScience,Cochrane中央受控试验和ClinicalTrials.gov）从开始到2023年9月25日进行了搜索。
结果：主要结局是干预组和对照组在办公室收缩压（SBP）和办公室舒张压（DBP）相对于基线的变化方面的差异。次要结局是干预组和对照组的24小时平均动态收缩压（24小时SBP）变化的差异，基线的24小时平均动态舒张压(24小时DBP)和心率(HR)。
结果：共有23项研究比较了五种维生素（维生素B2，维生素C，维生素D,维生素E,叶酸），并包括2218名参与者。纳入的试验都是维生素和安慰剂，所以网络是星形的。在五种维生素中，只有维生素E在降低SBP方面显着更有效（平均差异：-14.14mmHg，95%可信区间：-27.62至-0.88）比安慰剂。此外,没有证据表明五种维生素中的任何一种都会影响DBP，24小时SBP,24小时DBP,或HR。维生素的剂量，地理区域和男性百分比(仅SBP)可能是异质性的来源。敏感性和亚组分析显示，维生素干预对血压的影响因维生素剂量的不同而异。
结论：根据结果，维生素E可能是降低SBP的有效措施，但需要更多的研究来验证这一发现。
■CRD42022352332。
