目的:本研究的目的是调查1990年至2019年可归因于呼吸道合胞病毒(RSV)的下呼吸道感染(LRI)负担的全球流行病学特征。
方法:我们使用最近的2019年全球疾病负担研究(GBD)来系统地评估全球可归因于RSV的LRI负担的当前负担和时间趋势,年龄,性别,地理位置,和社会经济地位。
结果:全球,可归因于RSV的LRI的残疾调整生命年(DALYs)病例从1990年的估计39,964,488[95%不确定性区间(UI):16,825,572至68,800,553]下降到2019年的14,956,514(95%UI:6,271,751至25,910,753),估计死亡病例从1990年的1,172(95下降到同样,可归因于RSV的LRI的年龄标准化DALY率从1990年的估计646.2(95%UI:276.9至1121.5)降至2019年的218.3(95%UI:92.1至376.8),年龄标准化死亡率从1990年至2019年的10.3(95%UI:4.1至18.5)降至4.8(95%UI:1.8至9.3).2019年,可归因于RSV的LRI的年龄标准化DALYs和死亡率最高的是在较低的SDI地区,孩子和老人。从1990年到2019年,年龄标准化的DALYs和可归因于RSV的LRI死亡率随着SDI的增加而下降。
结论:在这项研究中,我们发现,从1990年到2019年,RSV导致的LRI负担显著下降。然而,较低的SDI区域,儿童和老年人迫切需要具有成本效益的干预措施,以预防和减轻RSV引起的LRI负担。
OBJECTIVE: The purpose of this
study is to investigate the global epidemiological characteristics of lower respiratory infections (LRI) burden attributable to respiratory syncytial virus (RSV) from 1990 to 2019.
METHODS: We used the recent Global Burden of Disease
Study (GBD) 2019 to systematically evaluate the current burden and temporal trend of LRI burden attributable to RSV by global, age, sex, geographic location, and socio-economic status.
RESULTS: Globally, the disability-adjusted life years (DALYs) cases of LRI attributable to RSV dropped from an estimated 39,964,488 [95% uncertainty interval (UI): 16,825, 572 to 68,800,553] in 1990 to 14,956,514 (95%UI: 6,271,751 to 25,910,753) in 2019 and estimated death cases droped from 541,172 (95%UI:226,614 to 958,596) to 338,495 (95%UI:126,555 to 667,109) from1990 to 2019. Similarly, age-standardized DALYs rate of LRI attributable to RSV decreased from an estimated 646.2 (95%UI: 276.9 to 1121.5) in 1990 to 218.3 (95%UI:92.1 to 376.8) in 2019 and estimated age-standardized deaths rate decreased from 10.3 (95%UI:4.1 to 18.5) to 4.8 (95%UI:1.8 to 9.3) between 1990 and 2019. In 2019, the highest age-standardized DALYs and death rates of LRI attributable to RSV were seen in the lower SDI regions, children and old people. From 1990 to 2019, age-standardized DALYs and death rates of LRI attributable to RSV decreased with increasing SDI.
CONCLUSIONS: In this
study, we found that the LRI burden attributable to RSV decreased significantly from 1990 to 2019. However, the lower SDI regions, children and old people urgently require cost-effective interventions to prevent and reduce the LRI burden attributable to RSV.