Research methodology

研究方法
  • 文章类型: Journal Article
    目的:已经开发了用于评估横断面研究的潜在偏倚风险(RoB)的不同工具,但目前尚不清楚是否解决了所有相关的偏见概念。我们旨在确定适用于横断面研究有效性的RoB概念,并探索现有评估工具中每个概念的覆盖范围。
    方法:这项范围审查遵循了乔安娜·布里格斯研究所的方法。我们包括任何描述或报告方法的研究设计记录,在健康研究中用于考虑RoB的概念或工具报告为描述性/患病率调查或分析/关联(横断面)研究设计。综合包括定量和定性分析。
    结果:在筛选的4,556条记录中,90人被选中纳入;67人(74%)描述了发展,或验证过程,评估工具,15(17%)描述了与RoB相关的方法学内容或理论,用于横断面研究,8(9%)记录了方法学系统综述。方法学报告的审查确定了用于描述性/患病率和分析/关联研究的重要RoB概念。确定的工具(n=64个独特的工具)旨在评估质量或评估多项研究设计中的RoB,包括横断面研究(n=21;33%)或仅横断面设计(n=43;67%)。对几种现有工具进行了修改(n=17;27%),以应用于横断面研究。RoB工具中最常见的RoB项目是暴露(53%)或结果(65%)测量的有效性和可靠性以及研究人群的代表性(59%)。大多数工具都没有适当地或根本没有考虑到无响应或错误。
    结论:评估横断面研究涉及独特的偏倚风险(RoB)考虑因素。我们确定了设计用于各种研究设计的广泛适用性的RoB工具,以及专门为横断面研究量身定制的工具。然而,已确定的工具均未全面解决与横断面研究相关的所有潜在偏见.我们的发现表明需要持续改进RoB工具,并建议开发针对此研究设计的特定环境或更精确的工具可能是必要的。
    OBJECTIVE: Different tools to assess the potential risk of bias (RoB) for cross-sectional studies have been developed, but it is unclear whether all pertinent bias concepts are addressed. We aimed to identify RoB concepts applicable to cross-sectional research validity and to explore coverage for each in existing appraisal tools.
    METHODS: This scoping review followed the Joanna Briggs Institute methodology. We included records of any study design describing or reporting methods, concepts or tools used to consider RoB in health research reported to be descriptive/prevalence survey or analytic/association (cross-sectional) study designs. Synthesis included quantitative and qualitative analysis.
    RESULTS: Of the 4556 records screened, 90 were selected for inclusion; 67 (74%) described the development of, or validation process for, appraisal tools, 15 (17%) described methodological content or theory relevant to RoB for cross-sectional studies and 8 (9%) records of methodological systematic reviews. Review of methodological reports identified important RoB concepts for both descriptive/prevalence and analytic/association studies. Tools identified (n = 64 unique tools) were either intended to appraise quality or assess RoB in multiple study designs including cross-sectional studies (n = 21; 33%) or cross-sectional designs alone (n = 43; 67%). Several existing tools were modified (n = 17; 27%) for application to cross-sectional studies. The RoB items most frequently addressed in the RoB tools were validity and reliability of the exposure (53%) or outcome (65%) measurement and representativeness of the study population (59%). Most tools did not consider nonresponse or missingness appropriately or at all.
    CONCLUSIONS: Assessing cross-sectional studies involve unique RoB considerations. We identified RoB tools designed for broad applicability across various study designs as well as those specifically tailored for cross-sectional studies. However, none of the identified tools comprehensively address all potential biases pertinent to cross-sectional studies. Our findings indicate a need for continued improvement of RoB tools and suggest that the development of context-specific or more precise tools for this study design may be necessary.
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  • 文章类型: Journal Article
    目的:本研究的目的是回顾使用定性研究方法的基于医院的健康信息系统(HIS)研究,并评估其方法学背景和含义。此外,我们为计划使用定性研究方法的HIS研究人员提出了实用指南.
    方法:我们通过搜索PubMed和CINAHL数据库收集了2012年至2022年发表的论文。作为搜索关键字,我们使用了与HIS相关的特定系统术语,如“电子病历”和“临床决策支持系统”,“与他们的操作条款联系在一起,如“实施”和“适应”,“和定性方法论术语,如“观察”和“深度访谈”。“我们最终选择了74项符合本综述纳入标准的研究,并对所选研究进行了分析性综述。
    结果:我们根据以下四点对所选文章进行了分析:所选文章的一般特征;研究设计;参与者抽样,identification,和招聘;和数据收集,processing,和分析。这篇综述发现了有关研究人员反思的方法论问题,参与者抽样方法和研究可及性,和数据管理。
    结论:关于定性研究过程的报告应包括对研究人员的反思和伦理考虑的描述,这对于加强定性研究的严谨性和可信度具有重要意义。基于这些讨论,我们建议指导道德,可行,以及对医院环境中HIS的可靠定性研究。
    OBJECTIVE: The aim of this study was to review hospital-based health information system (HIS) studies that used qualitative research methods and evaluate their methodological contexts and implications. In addition, we propose practical guidelines for HIS researchers who plan to use qualitative research methods.
    METHODS: We collected papers published from 2012 to 2022 by searching the PubMed and CINAHL databases. As search keywords, we used specific system terms related to HISs, such as \"electronic medical records\" and \"clinical decision support systems,\" linked with their operational terms, such as \"implementation\" and \"adaptation,\" and qualitative methodological terms such as \"observation\" and \"in-depth interview.\" We finally selected 74 studies that met this review\'s inclusion criteria and conducted an analytical review of the selected studies.
    RESULTS: We analyzed the selected articles according to the following four points: the general characteristics of the selected articles; research design; participant sampling, identification, and recruitment; and data collection, processing, and analysis. This review found methodologically problematic issues regarding researchers\' reflections, participant sampling methods and research accessibility, and data management.
    CONCLUSIONS: Reports on the qualitative research process should include descriptions of researchers\' reflections and ethical considerations, which are meaningful for strengthening the rigor and credibility of qualitative research. Based on these discussions, we suggest guidance for conducting ethical, feasible, and reliable qualitative research on HISs in hospital settings.
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  • 文章类型: Journal Article
    尽管进行了数十年的社会流行病学研究,健康不平等在加拿大和其他地方仍然普遍存在和无处不在。一个原因可能是我们使用社会经济衡量标准,这通常依赖于单一的时间点暴露。为了探索研究人员将动态社会经济测量纳入心血管健康结果评估的程度,我们进行了叙述性审查。我们估计了社会经济纵向心血管研究的患病率,这些研究在2019年至2023年之间的两个或多个时间点确定了社会经济暴露。我们将心血管结局研究定义为检查冠状动脉疾病的研究,心肌梗塞,急性冠脉综合征,中风,心力衰竭,心律失常,心脏死亡,心脏代谢因子,短暂性脑缺血发作,外周动脉疾病,或高血压。社会经济风险包括个人收入,邻里收入,代际社会流动,教育,职业,保险状况,和经济安全。7%的社会经济心血管结局研究在整个随访期间测量了两个或多个时间点的社会经济状况。动态社会经济措施影响结果的假设机制集中在社会流动性上,积累,和关键时期理论。洞察力,含义,并讨论了未来的方向,其中我们强调了邮政编码数据的方式,可以在方法上更好地利用它作为一种动态的社会经济措施。未来的研究必须纳入动态的社会经济测量,以更好地揭示根本原因,干预措施,和卫生系统设计,如果要改善卫生公平。
    Despite decades of social epidemiologic research, health inequities remain pervasive and ubiquitous in Canada and elsewhere. One reason may be our use of socioeconomic measurement, which has often relied on single point-in-time exposures. To explore the extent to which researchers have incorporated dynamic socioeconomic measurement into cardiovascular health outcome evaluations, we performed a narrative review. We estimated the prevalence of socioeconomic longitudinal cardiovascular research studies that identified socioeconomic exposures at 2 or more points in time between the years of 2019 and 2023. We defined cardiovascular outcome studies as those that examined coronary artery disease, myocardial infarction, acute coronary syndrome, stroke, heart failure, cardiac arrhythmias, cardiac death, cardiometabolic factors, transient ischemic attacks, peripheral artery disease, or hypertension. Socioeconomic exposures included individual income, neighbourhood income, intergenerational social mobility, education, occupation, insurance status, and economic security. Seven percent of socioeconomic cardiovascular outcome studies have measured socioeconomic status at 2 or more points in time throughout the follow-up period, hypothesized mechanisms by which dynamic socioeconomic measures affected outcome focused on social mobility, accumulation, and critical period theories. Insights, implications, and future directions are discussed, in which we highlight ways in which postal code data can be better used methodologically as a dynamic socioeconomic measure. Future research must incorporate dynamic socioeconomic measurement to better inform root causes, interventions, and health-system designs if health equity is to be improved.
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  • 文章类型: Journal Article
    多年的牙科研究结果是医学实践的基础,就此而言,牙科。医生可能对技术和材料有自己的偏好,但是无论是直接还是间接,他们的决策受到系统评价和荟萃分析的影响.然而,由于研究进行得不好或提出得不好,这个非常基本的基础可能不可靠。研究中的偏见是可能使研究结果或研究本身不可靠的几个因素之一。偏见可以在许多阶段引入研究,故意或不知不觉。偏见可以出现在研究过程中的任何时候,甚至在研究本身开始之前。在研究中有很多偏见,但其中一些与牙科研究更相关。因为据说“眼睛看到头脑知道的东西”,必须全面了解不同类型的偏见,他们如何以及何时根深蒂固,以及如果它们确实发生,可以采取什么步骤来防止或减轻它们。这篇综述提供了牙科研究偏见的全面总结。目标是通过提供描述性和评估性摘要来确定已经采取或应该采取的差距和措施,以及文献中的例子,当需要的时候。
    The results of years of dental study serve as the foundation for the practise of medicine and, for that matter, dentistry. Doctors may have their own preferences for techniques and materials, but whether directly or indirectly, their decisions are influenced by systematic reviews and meta-analyses. However, due to poorly conducted or presented research, this very basic foundation may not be reliable. Bias in research is one of several factors that might make study results or research itself unreliable. Bias can be introduced into research at many stages, deliberately or unknowingly. Bias can appear at any point during the research process, even before the study itself begins. There are many biases in research, but some of them are more relevant to dentistry research than others. Because it is said that \"eyes see what the mind knows\", it is essential to have a complete understanding of the different types of bias, how and when they get entrenched, and what steps may be taken to prevent or lessen them if they do occur. This comprehensive summary of bias in dentistry research is provided by this synoptic review. The goal is to identify gaps and measures that have been taken-or that should have been taken-by providing both descriptive and evaluative summaries, as well as examples from the literature, when needed.
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  • 文章类型: Journal Article
    背景:了解堕胎护理的障碍在Dobbs后尤为重要。然而,许多堕胎准入研究从堕胎提供机构招募,这忽略了不参加诊所护理的个人。据我们所知,没有研究回顾文献中的研究招募策略,也没有研究它们如何影响我们对堕胎障碍的认识.我们旨在确定美国(US)堕胎障碍研究中包含的人群和采样方法。
    方法:我们使用范围审查方案在5个数据库中搜索了研究美国个体堕胎经历的文章。我们纳入了2011年1月至2022年2月期间发表的英文文章。对于纳入的研究,我们确定了抽样策略和招募的人群.
    结果:我们的搜索产生了2,763篇文章,其中71人符合纳入标准。一半的论文包括在堕胎提供机构招募的参与者(n=35),而其余的是从网上招募的(n=14),其他诊所(n=10),专业组织(n=8),堕胎基金(n=2),社区组织(n=2),关键线人(n=2),和堕胎讲故事项目(n=1)。大多数文章(n=61)报道了人们讨论自己堕胎的信息;其余的询问非堕胎寻求者(例如,医师,遗传咨询师,律师)关于护理障碍。
    结论:堕胎障碍研究招募了来自一系列场所的参与者,但是大多数招募堕胎的人,一半从堕胎诊所招募。随着堕胎在后Roe环境中受到限制并被定罪,我们的研究结果表明,研究者可能会从不同的环境中招募研究参与者,以充分了解寻求堕胎的经历.
    Understanding barriers to abortion care is particularly important post-Dobbs. However, many abortion access studies recruit from abortion-providing facilities, which overlook individuals who do not present for clinic-based care. To our knowledge, no studies have reviewed research recruitment strategies in the literature or considered how they might affect our knowledge of abortion barriers. We aimed to identify populations included and sampling methods used in studies of abortion barriers in the United States.
    We used a scoping review protocol to search five databases for articles examining US-based individuals\' experiences accessing abortion. We included English-language articles published between January 2011 and February 2022. For included studies, we identified the sampling strategy and population recruited.
    Our search produced 2763 articles, of which 71 met inclusion criteria. Half of the included papers recruited participants at abortion-providing facilities (n = 35), while the remainder recruited from online sources (n = 14), other health clinics (n = 10), professional organizations (n = 8), abortion funds (n = 2), community organizations (n = 2), key informants (n = 2), and an abortion storytelling project (n = 1). Most articles (n = 61) reported information from people discussing their own abortions; the rest asked nonabortion seekers (e.g., physicians, genetic counselors, attorneys) about barriers to care.
    Studies of abortion barriers enroll participants from a range of venues, but the majority recruit people who obtained abortions, and half recruit from abortion clinics.
    As abortion access becomes constrained and criminalized in the post-Roe context, our findings indicate how investigators might recruit study participants from a variety of settings to fully understand the abortion seeking experience.
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  • 文章类型: Journal Article
    目的:确定自我报告与方法间的一致性登记\'病假\'(SA)和\'返回工作\'(RTW)结果测量的数据。
    方法:我们对报告平均差异(MD)以及自我报告与敏感性和特异性的研究进行了系统评价和荟萃分析登记数据和对自我报告问题表述的归纳分析。一名信息专家搜索了Medline,Embase,PsycINFO从开始到2022年11月发表的研究。筛选和数据提取由两名作者独立完成。
    结果:纳入了23项研究,其中18项总体偏倚风险较高。自我报告的合并MD为1.84SA天(95%置信区间[CI]0.26-3.41,I298%,18项研究,38,716名参与者),而研究中的注册记录从204天多到17天不等。自我报告组研究中的平均病假中位数为8天(四分位数范围4-23天)。与注册数据相比,用自我报告测量的缺勤敏感性为0.83(0.76-0.8895%CI),特异性为0.92(0.88-0.9495%CI)。研究中的高度异质性不能用回忆时间来解释,性别,寄存器类型,前瞻性或回顾性自我报告,健康问题,基线时的SA或偏倚风险。研究缺乏标准的结果报告,在自我报告中提出了不清楚的问题,关于登记册质量的信息很少。
    结论:当前的自我报告可能与基于注册的缺勤数据不同,但方式不一致。由于不一致和偏见的高风险,证据被认为具有非常低的确定性。需要进一步研究以制定明确的标准问题,可用于SA和RTW自我报告。需要更好地评估寄存器的质量。积极和消极一致的百分比,对于调查SA和RTW结果测量之间协议的研究,应报告MD和2×2表。
    OBJECTIVE: To determine the intermethod agreement of self-reported vs. register data of \'sickness absence\' (SA) and \'return to work\' (RTW) outcome measurements.
    METHODS: We conducted a systematic review and a meta-analysis of studies reporting mean differences (MDs) and sensitivity and specificity for self-report vs. register data and an inductive analysis of the self-report question formulations. An information specialist searched Medline, Embase, PsycINFO for studies published from inception to November 2022. Screening and data extraction was done by two authors independently.
    RESULTS: Twenty-three studies were included of which eighteen with an overall high risk of bias. Self-reports had a pooled MD of 1.84 SA days (95% confidence interval [CI] 0.26-3.41, I2 98%, 18 studies, 38,716 participants) compared to registries which varied among studies from 204 more to 17 days less. The median average sick leave in studies in the self-report group was 8 days (interquartile range 4-23 days). Being absent from work measured with self-report had a sensitivity of 0.83 (0.76-0.88 95% CI) and a specificity of 0.92 (0.88-0.94 95% CI) compared to registry data. The high heterogeneity amongst the studies could not be explained by recall time, gender, register type, prospective or retrospective self-reports, health problem, SA at baseline or risk of bias. Studies lacked standard outcome reporting, had unclearly formulated questions in self-reports and there was little information on the registers\' quality.
    CONCLUSIONS: Current self-reports may differ from register-based absence data but in an inconsistent way. Due to inconsistency and high risk of bias the evidence is judged to be of very low certainty. Further research is needed to develop clear standard questions which can be used for SA and RTW self-reports. Quality of registers needs to be better evaluated. Percentage positive and negative agreement, MDs and 2 × 2 tables should be reported for studies investigating agreement between SA and RTW outcome measures.
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  • 文章类型: Journal Article
    受微生物影响的混凝土腐蚀(MICC)给现代社会造成了巨大的经济损失。几十年来,人们对混凝土腐蚀与各种环境因素的关系进行了广泛的研究。随着公众对微生物腐蚀对环境和经济影响的认识的提高,MICC越来越引起公众的关注。在这次审查中,阐述了各种微生物群落对MICC的作用及相应的MICC防护措施。此外,讨论了MICC的研究现状和研究方法。因此,这项审查旨在深入了解MICC及其机制以及保护可能性的发展。
    Microbially influenced concrete corrosion (MICC) causes substantial financial losses to modern societies. Concrete corrosion with various environmental factors has been studied extensively over several decades. With the enhancement of public awareness on the environmental and economic impacts of microbial corrosion, MICC draws increasingly public attention. In this review, the roles of various microbial communities on MICC and corresponding protective measures against MICC are described. Also, the current status and research methodology of MICC are discussed. Thus, this review aims at providing insight into MICC and its mechanisms as well as the development of protection possibilities.
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  • 文章类型: Journal Article
    维基百科是一个开源的在线百科全书,也是最受欢迎的在线健康信息来源之一。同样,还对维基百科页面视图进行了分析,以告知公共卫生服务和政策。本综述分析了29项利用维基百科页面视图进行健康研究的研究。大多数综述的研究是近年来发表的,来自高收入国家。连同维基百科页面视图,大多数研究还使用其他互联网来源的数据,比如Google,Twitter,YouTube,Reddit审查的研究还探讨了各种非传染性疾病,传染病,和健康干预措施来描述维基百科在线健康信息利用的变化,为了检查公共事件对公共利益的影响以及与健康相关的维基百科页面的信息使用,估计和预测疾病的发病率和患病率,预测来自其他互联网数据源的数据,评估健康教育活动的有效性,并探索健康主题的演变。鉴于复制一些综述研究的局限性,未来的研究可以指定特定的维基百科页面或分析页面,维基百科页面的语言被检查,数据收集的日期,探索日期,数据类型,以及页面浏览量是否仅限于Internet用户,以及是否包括网络爬虫和重定向到Wikipedia页面。未来的研究还可以探索公众对维基百科上其他常见健康主题的兴趣,开发基于维基百科的模型,可用于预测疾病发病率和改善基于维基百科的健康教育活动。
    Wikipedia is an open-source online encyclopedia and one of the most-read sources of online health information. Likewise, Wikipedia page views have also been analyzed to inform public health services and policies. The present review analyzed 29 studies utilizing Wikipedia page views for health research. Most reviewed studies were published in recent years and emanated from high-income countries. Together with Wikipedia page views, most studies also used data from other internet sources, such as Google, Twitter, YouTube, and Reddit. The reviewed studies also explored various non-communicable diseases, infectious diseases, and health interventions to describe changes in the utilization of online health information from Wikipedia, to examine the effect of public events on public interest and information usage about health-related Wikipedia pages, to estimate and predict the incidence and prevalence of diseases, to predict data from other internet data sources, to evaluate the effectiveness of health education activities, and to explore the evolution of a health topic. Given some of the limitations in replicating some of the reviewed studies, future research can specify the specific Wikipedia page or pages analyzed, the language of the Wikipedia pages examined, dates of data collection, dates explored, type of data, and whether page views were limited to Internet users and whether web crawlers and redirects to the Wikipedia page were included. Future research can also explore public interest in other commonly read health topics available in Wikipedia, develop Wikipedia-based models that can be used to predict disease incidence and improve Wikipedia-based health education activities.
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  • 文章类型: Systematic Review
    背景:脆弱,神经变性和老年综合征在临床上造成重大影响,社会,和经济水平,主要是在老龄化世界的背景下。最近,信息和通信技术(ICT),虚拟现实工具,机器学习模型越来越多地应用于老年患者的护理,以改善诊断,预后,和干预。然而,到目前为止,该领域研究的方法论局限性阻止了将数据推广到真实单词。这篇综述系统地概述了应用技术评估和治疗老年人衰老相关综合征的研究设计。
    方法:遵循PRISMA指南,PubMed的记录,EMBASE,和WebofScience进行了系统筛选,以选择原始文章,其中使用了介入或观察性设计来研究技术在脆弱样本中的应用,共病,或者多病人。
    结果:34篇符合纳入标准。大多数研究使用诊断准确性设计来测试评估程序或回顾性队列设计来构建预测模型。少数为随机或非随机介入研究。质量评估显示,观察性研究存在很高的偏倚风险,而介入研究的偏倚风险较低。
    结论:大多数审查的文章主要使用观察性设计来研究诊断程序,并且存在较高的偏倚风险。方法学上健壮的介入研究很少,这可能表明该领域处于起步阶段。将介绍如何标准化该领域的程序和研究质量的方法。
    Frailty, neurodegeneration and geriatric syndromes cause a significant impact at the clinical, social, and economic level, mainly in the context of the aging world. Recently, Information and Communication Technologies (ICTs), virtual reality tools, and machine learning models have been increasingly applied to the care of older patients to improve diagnosis, prognosis, and interventions. However, so far, the methodological limitations of studies in this field have prevented to generalize data to real-word. This review systematically overviews the research designs used by studies applying technologies for the assessment and treatment of aging-related syndromes in older people.
    Following the PRISMA guidelines, records from PubMed, EMBASE, and Web of Science were systematically screened to select original articles in which interventional or observational designs were used to study technologies\' applications in samples of frail, comorbid, or multimorbid patients.
    Thirty-four articles met the inclusion criteria. Most of the studies used diagnostic accuracy designs to test assessment procedures or retrospective cohort designs to build predictive models. A minority were randomized or non-randomized interventional studies. Quality evaluation revealed a high risk of bias for observational studies, while a low risk of bias for interventional studies.
    The majority of the reviewed articles use an observational design mainly to study diagnostic procedures and suffer from a high risk of bias. The scarce presence of methodologically robust interventional studies may suggest that the field is in its infancy. Methodological considerations will be presented on how to standardize procedures and research quality in this field.
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  • 文章类型: Journal Article
    最近开发了两个用于MEDLINE的去处方搜索过滤器和一个用于Embase的去处方搜索过滤器,包括客观开发的搜索过滤器。本案例研究的目的是在系统评价(SR)搜索策略中实施这三个取消处方的搜索过滤器,并评估其对性能的影响。选择独立开发原始搜索策略(OSS)的SR。去处方过滤器在每个OSS中实现,在MEDLINE中生成两个已实施的搜索策略(ISS1和ISS2),在Embase中生成一个ISS(ISS3)。OSS与ISS在同一日期重新运行。计算并比较了ISS和OSS的性能。包括两个SR(SR1和SR2)。对于MEDLINE,SR1包括12篇文章。OSS的灵敏度为50%,58%的ISS1和42%的ISS2。SR2包括四篇文章。OSS的灵敏度,ISS1和2为25%。对于Embase,SR1包括12篇文章。OSS的灵敏度为33%,ISS3的灵敏度为58%。SR2包括四篇文章。所包含的四篇文章均未通过OSS或ISS3检索到。虽然OSS的敏感性是中等的,客观开发的去处方过滤器在实施时保持或略微改善了这种灵敏度。
    Two deprescribing search filters for MEDLINE and one deprescribing search filter for Embase have been recently developed, including objectively developed search filters. The objective of this case study was to implement these three deprescribing search filters in systematic review (SR) search strategies and to assess their effect on performances. SR that independently developed original search strategies (OSS) were selected. The deprescribing filters were implemented in each OSS, generating two implemented search strategies (ISS1 and ISS2) in MEDLINE and one ISS (ISS3) in Embase. OSS were re-run on the same date as ISS. The performances of ISS and OSS were calculated and compared. Two SR were included (SR1 and SR2). For MEDLINE, SR1 included 12 articles. The sensitivity was 50% for OSS, 58% for ISS1 and 42% for ISS2. SR2 included four articles. The sensitivity of OSS, ISS 1 and 2 was 25%. For Embase, SR1 included 12 articles. The sensitivity was 33% for OSS and 58% for ISS3. SR2 included four articles. None of the four included articles were retrieved with OSS or ISS3. While sensitivity of OSS was moderate, the objectively developed deprescribing filters maintained or slightly improved this sensitivity when implementing.
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