■局部视网膜血氧饱和度是一种研究技术,它有可能作为糖尿病的生物标志物。然而,规范性数据尚未建立。这项研究检查了黄斑周围氧饱和度的差异,并描述了年龄之间的关系,种族,屈光不正(RE),性别,血压(BP),糖尿病前期状态和氧饱和度。
■59名年龄在22-69岁(38.8±14.7岁)的受试者包括种族多样性和性别分布相等的受试者。没有人患有眼病。使用ZiliaEocular在距中央凹3.1度的黄斑周围的4个位置测量氧饱和度,并将其平均。BP,RE,并注意到HbA1c。完成了对血氧饱和度和其他因素的回归分析,并进行了多次比较校正的t检验。
■血氧测量因种族而异,较高的色素沉着水平与较低的血氧值相关(p<0.01)。血氧饱和度与性别之间没有关系(p=0.34),RE(p=0.67),血压(收缩压p=0.61,舒张压p=0.71)或糖尿病前期状态(p=0.87)。控制种族时,血氧测定与年龄相关(P<0.002)。经鼻-颞部变异显示鼻血氧含量高于颞部(P<0.01)。
■这项研究表明种族/色素沉着是对血氧测定的重要影响。视网膜位置也会引起变异,可能是由于靠近鼻侧较大的血管。没有性别差异,观察到RE和BP都改变了局部氧饱和度。然而,考虑到年龄与种族相关。这项研究将为我们未来在不同疾病状态下的工作提供信息,并且是评估这项技术的重要第一步。
这项研究评估了一种新的研究仪器(ZiliaOcular),该仪器可以测量视网膜非常小的血管中的氧气量。我们小组希望对健康人进行评估,以了解仪器在不同性别中的测量值是否不同,年龄,种族,眼镜处方和血压。我们还研究了糖尿病前期患者是否发生了变化,以及视网膜上不同位置的变化是否不同。我们发现,不同种族和年龄的措施是不同的。测量也随着眼睛中的位置而改变。其他因素没有改变该仪器上的氧饱和度测量值。我们需要知道这些信息,因为我们想要检测不同患者群体中糖尿病视网膜的变化;然而,我们需要了解正常变化,以便更好地理解和收集这些数据。
UNASSIGNED: Local retinal oxygen saturation is a research technique, which has the potential as a biomarker for diabetes. However, normative data has not been established. This study examined differences in oxygen saturation around the macula and characterizes the relationship between age, race, refractive error (RE), sex, blood pressure (BP), prediabetic status and oxygen saturation.
UNASSIGNED: Fifty-nine subjects aged 22-69 (38.8 ± 14.7 years) were included who were racially diverse and with equal gender distribution. None had eye disease. Oxygen saturation was taken with the Zilia Ocular in 4 locations around the macula 3.1 degrees from the fovea and they were also averaged. BP, RE, and HbA1c were noted. Regression analyses for oximetry and other factors were completed as were t-tests with multiple comparison corrections.
UNASSIGNED: There were significant variations in oximetry measures by race, with higher pigmentation levels associated with lower oximetry values (p < 0.01). There was no relationship between oximetry and sex (p = 0.34), RE (p = 0.67), BP (systolic p = 0.61, diastolic p = 0.71) nor prediabetic status (p = 0.87). Oximetry was associated with age when controlling for race (P < 0.002). Nasal-temporal variations showed nasal oximetry to higher than temporal measures (P < 0.01).
UNASSIGNED: This study revealed race/pigmentation is an important influence on oximetry measures. Retinal location also caused variations, likely due to proximity to larger vessels nasally. No differences in sex, RE nor BP were observed to alter local oxygen saturation. However, age was correlated when considered with race. This study will inform our future work in different disease states and is an important first step in evaluating this technology.
This study evaluates a new research instrument (Zilia Ocular) which measures how much oxygen is in the very small blood vessels of the retina. Our group wanted to evaluate healthy people to find out if the measurements the instrument takes are different in different sexes, ages, races, glasses prescriptions and blood pressures. We also looked at if they were changed in people with prediabetes and if it is different in different locations on the retina. We found that the measures are different in different races and ages. The measures also change with location in the eye. The other factors did not change the measurements of oxygen saturation on this instrument. We need to know this information because we want to detect changes in the retina in diabetes in diverse patient groups; however, we need to know about normal variations to better understand and collect that data.