头发皮质醇浓度(HCC)已显示出显著的希望,全身皮质醇的非侵入性测量;然而,尽管方法取得了进步,通常在健康成年人中看到的价值尚未确定。因此,我们试图回顾相关文献,以确定健康肝癌的参考值(即,非临床)成人。为此,我们对PubMed进行了系统的审查,Scopus,和CINAHL数据库,用于使用免疫分析方法测量健康成人HCC的研究,鉴于这些是最广泛使用的分析工具。有资格,研究必须以英文发表,提供了相关的描述性统计数据(即,均值和标准差),并使用了健康的成年人样本。我们发现17项研究符合我们的纳入标准;这些报告涉及1348名参与者,平均年龄约38岁。由于我们发现了大量的研究之间的异质性,我们完成了随机效应meta回归分析,发现检测试剂盒供应商是模型中唯一有意义的变量.因此,当使用传统有限混合分布的方法来确定个体健康成年人中平均和升高的HCC的参考值时,我们计算了每个主要测试套件供应商的这些估计值。未来的工作将需要确定我们的估计参考值是否需要修改,这些努力将得到解释潜在调节因素的研究的极大帮助,比如年龄,性别,和种族。
Hair cortisol concentration (HCC) has shown remarkable promise as a stable, non-invasive measure of systemic cortisol; however, despite methodological advances, the value that would typically be seen in healthy adults has not been established. Therefore, we sought to
review the relevant literature to determine a reference value for HCC in healthy (i.e., non-clinical) adults. To this end, we conducted a systematic
review of the PubMed, Scopus, and CINAHL databases for studies that measured healthy adult HCC using immunoassay methods, given that these are the most widely accessible analytical tools. To be eligible, studies were required to have been published in English, to have provided relevant descriptive statistics (i.e., means and standard deviations), and to have used a healthy adult human sample. We found 17 studies that met our inclusion criteria; the reports involved 1348 participants with a mean age of about 38 years. Since we identified a large amount of between-study heterogeneity, we completed a random-effect meta-regression analysis and found that test kit vendor was the only significant variable of the model. As a result, when using methodologies from traditional finite mixture distributions to determine reference values for mean and elevated HCC in individual healthy adults, we calculated these estimates for each of the major test kit vendors. Future work will need to determine whether our estimated reference values need to be modified, and these efforts will be greatly assisted by studies that account for potential moderating factors, such as age, sex, and ethnicity.