PDF(Pubmed)
Abstract：
Alpha-fetoprotein (AFP) is a serum protein highly produced during the fetal period. It is also known as a biomarker of various pathologies. Commonly, tumors requiring diagnosis and monitoring through AFP determination appear during the first year of life, with poorer outcomes when presenting in fetal life. Due to advancements in imaging technology, the detectability of ovarian masses in infants is higher. However, the use of AFP as a biomarker could improve diagnosis in cases when imaging and histological examinations are not sensitive enough to detect tumors. From the outcome of our investigation, it is possible to conclude that there is evidence of an association between increased AFP levels and ovarian masses. However, previous studies have presented contradictory and unverified results, with the authors emphasizing that future research is needed. In this article, an analysis of the available literature on AFP as a biomarker of ovarian masses in children was performed. Two types of literature were reviewed: guidance and published studies (clinical trials, reviews, and systematic reviews). We searched the Embase, PubMed, ScienceDirect, and Web of Science databases to collect essential data.
摘要：
甲胎蛋白（AFP）是在胎儿期大量产生的血清蛋白。它也被称为各种病理的生物标志物。通常,需要通过AFP测定进行诊断和监测的肿瘤出现在生命的第一年，在胎儿生命中表现较差的结局。由于成像技术的进步，婴儿卵巢肿块的可检测性较高。然而,在影像学和组织学检查对检测肿瘤不够敏感的情况下,使用AFP作为生物标志物可以改善诊断.从我们的调查结果来看,可以得出结论,有证据表明AFP水平升高与卵巢肿块之间存在关联.然而,以前的研究提出了矛盾和未经证实的结果，作者强调未来的研究是必要的。在这篇文章中,我们对现有的关于AFP作为儿童卵巢肿块生物标志物的文献进行了分析.审查了两种类型的文献：指导和已发表的研究(临床试验，reviews,和系统评价)。我们搜查了Embase,PubMed,ScienceDirect,和WebofScience数据库来收集基本数据。
