疼痛是类风湿关节炎(RA)患者报告的最常见症状,即使在慢性关节炎症消退后也是如此。人们认为,RA相关的疼痛不仅仅是由于炎症,但也可能归因于中枢神经系统的异常改变。P2X4受体(P2X4R)是一种ATP激活的嘌呤能受体,在神经系统和疼痛中的信息传递中起着重要作用。P2X4R在慢性炎性疼痛和神经性疼痛的发病机理中的参与是公认的。这种受体的减弱减轻了疾病的发病机制和相关症状,包括痛觉过敏和异常性疼痛。尽管一些研究揭示了P2X4R在促进RA关节炎症中的作用,它如何暗示周围和中枢神经系统与RA相关的疼痛仍然缺乏。在这次审查中,研究了P2X4R在神经系统中的可能作用以及它如何影响疼痛传递和反应。
Pain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is believed that RA-associated pain is not solely due to inflammation, but could also be attributed to aberrant modifications to the central nervous system. The P2X4 receptor (P2X4R) is an ATP-activated purinergic receptor that plays a significant role in the transmission of information in the nervous system and pain. The involvement of P2X4R during the pathogenesis of chronic inflammatory pain and neuropathic pain is well-established. The attenuation of this receptor alleviates disease pathogenesis and related symptoms, including hyperalgesia and allodynia. Although some studies have revealed the contribution of P2X4R in promoting joint inflammation in RA, how it implicates pain associated with RA at peripheral and central nervous systems is still lacking. In this
review, the possible contributions of P2X4R in the nervous system and how it implicates pain transmission and responses were examined.