目的:我们的研究目的是研究13种单核苷酸多态性对炎症性肠病(IBD)的影响。包括克罗恩病(CD)和溃疡性结肠炎(UC)。
方法:从包括PubMed在内的书目数据库中检索到44篇文章,Embase,SpingerLink,WebofScience,中国国家知识基础设施(CNKI),还有万方。通过全面的过滤程序,在荟萃分析中收集了13个单核苷酸多态性,这是由ReviewManager5.0完成的。
结果:经过系统过滤,我们的荟萃分析涉及44篇文章中的13种单核苷酸多态性(SNPs).我们的结果表明,发现3个SNP与CD/UC/IBD显着相关:IRF5rs4728142(UC:OR=1.21,95%CI=1.09-1.35,P=0.0003;OR=1.30,95%CI=1.08-1.57,亚洲人群P=0.006),PTGER4rs4613763(CD:总OR=1.28,95%CI=1.01-1.64,P=0.04;IBD:OR=1.31,95%CI=1.04-1.65,P=0.02),IL12Brs6887695(CD:总OR=1.17,95%CI=1.06-1.30,P=0.002;UC:总OR=1.13,95%CI=1.01-1.26,P=0.03;IBD:总OR=1.15,95%CI=1.06-1.24,P=0.0009)。
结论:我们的荟萃分析表明SNP(IRF5rs4728142,PTGER4rs4613763和IL12Brs6887695)与CD/UC/IBD之间存在显著关联。
OBJECTIVE: The goal of our study is to investigate the contribution of the 13 single-nucleotide polymorphisms to inflammatory bowel disease (IBD), including Crohn\'s disease (CD) and Ulcerative colitis (UC).
METHODS: A total of 44 articles were retrieved from bibliographic databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Through a comprehensive filtering procedure, 13 single-nucleotide polymorphisms were collected in the meta-analysis, which was done by
Review Manager 5.0.
RESULTS: After a systematic filtration, there were 13 single-nucleotide polymorphisms (SNPs) from 44 articles involved in our meta-analysis. Our results demonstrated that 3 SNPs were found to be significantly associated with CD/UC/IBD: IRF5 rs4728142 (UC: OR = 1.21, 95% CI = 1.09-1.35, P = 0.0003; OR = 1.30, 95% CI = 1.08-1.57, P = 0.006 in Asian), PTGER4 rs4613763 (CD: the overall OR = 1.28, 95% CI = 1.01-1.64, P = 0.04; IBD: OR = 1.31, 95% CI = 1.04-1.65, P = 0.02), IL12B rs6887695 (CD: the overall OR = 1.17, 95% CI = 1.06-1.30, P = 0.002; UC: the overall OR = 1.13, 95% CI = 1.01-1.26, P = 0.03; IBD: the overall OR = 1.15, 95% CI = 1.06-1.24, P = 0.0009).
CONCLUSIONS: Our meta-analyses have indicated the significant associations between SNPs (IRF5 rs4728142, PTGER4 rs4613763, and IL12B rs6887695) and CD/UC/IBD.