证据表明,自杀行为的责任是可遗传的;此外,自杀部分与其他精神疾病有关。然而,到目前为止,大多数报告的信息都针对高加索人和亚洲人。因此,我们的目的是在被诊断为自杀未遂的墨西哥精神病患者中进行基因水平关联研究.
我们从墨西哥的两个临床中心招募了192人。所有参与者都出生在墨西哥,有墨西哥的父母和祖父母。使用商业平台InfiniumPsychArrayBeadChip进行直接基因分型。低于1e-05的p值被认为是基因水平显著的,低于1e-04的p值被认为是基因水平标称显著的。
我们的分析表明,SCARA5在基因水平上与自杀意图相关,具有统计学意义(p值=1.12e-6)。其他基因名义上与自杀未遂相关:GHSR(p值=0.0004),RGS10(p值=5.13e-5),和STK33(p值=3.62e-5)。关于基因变异分析,具有统计相关性(p>.05)的SNP为rs561361616,rs1537577,rs11198999(RGS10)和rs11041981,rs11041993,rs11041994,rs11041995,rs11041997,rs10840083,rs10769918(STK33)。对于这些基因,以前的研究已经将SCARA5与抑郁症联系起来,GHSR有酒精依赖和抑郁症,和RGS10患有精神分裂症和抑郁症。迄今为止,STK33与任何精神疾病无关。
我们的结果显示,SCARA5,GHSR,在我们的墨西哥精神病样本中,RGS10和STK33可以被认为是自杀未遂行为的风险生物标志物。我们建议进行更大规模的分析以获得结论性结果。
Evidence suggests that liability for suicide behavior is heritable; additionally, suicide has been partly related to other psychiatric disorders. Nevertheless, most of the information reported so far address Caucasian and Asian individuals. Hence, our aim was to conduct a gene-level association
study in Mexican psychiatric individuals diagnosed with suicide attempt.
We recruited 192 individuals from two clinical centers in Mexico. All participants were born in Mexico and had Mexican parents and grandparents. Direct genotyping was performed using the commercial platform Infinium PsychArray BeadChip. A p-value lower than 1e-05 was considered as gene-level significant and a p-value lower than 1e-04 was considered as gene-level nominal significant.
Our analyses showed that SCARA5 was associated to suicide intent at a gene-level with statistical significance (p-value = 1.12e-6). Other genes were nominally associated with suicide attempt: GHSR (p-value = 0.0004), RGS10 (p-value = 5.13e-5), and STK33 (p-value = 3.62e-5). Regarding gene variant analyses, the SNPs with a statistical association (p > .05) were rs561361616, rs1537577, rs11198999 for RGS10, and rs11041981, rs11041993, rs11041994, rs11041995, rs11041997, rs10840083, rs10769918 for STK33. For these genes, previous studies have associated SCARA5 with depression, GHSR with alcohol dependence and depression, and RGS10 with schizophrenia and depression. To date, STK33 has not been associated with any psychiatric disorder.
Our outcomes revealed that SCARA5, GHSR, RGS10 and STK33 could be considered as risk biomarkers for suicide attempt behavior in our Mexican psychiatric sample. We recommend to perform larger scale analyses to have conclusive results.