背景:注意缺陷/多动障碍(ADHD)是一种与几种负面结果有关的普遍疾病,其病理生理学仍然知之甚少。自发性高血压大鼠(SHR)是最常用的ADHD动物模型。如何,其有效性,尤其是它的预测有效性,已被质疑。因此,当前的协议公开了背景,对哌醋甲酯(MPH)的行为影响进行系统评价和荟萃分析的研究的目的和方法,最常用的ADHD治疗方法,在SHR。
方法:研究将通过使用三个不同的电子数据库进行文献检索来确定:Medline,Embase和WebofScience。没有语言限制。所有向SHR管理MPH并评估运动能力的研究,注意,冲动或记忆将包括在内。
UASSIGNED:研究将根据标题和摘要进行预筛选,如有必要,将进行全文审查。筛选将由两名作者进行,任何分歧都将与第三作者讨论。
UNASSIGNED:数据提取将由两名独立作者根据标准化形式进行。研究将根据报告的行为结果进行分组,并对每组进行荟萃分析。将使用meta回归和敏感性分析评估预定义的协变量对MPH的影响。数据将按照PRISMA指南报告。
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent condition related to several negative outcomes, and its pathophysiology is still poorly understood. The spontaneously hypertensive rats (SHRs) are the most commonly used animal model of ADHD. How ever, its validity, and especially its predictive validity, has been questioned. Therefore, the current protocol discloses the background, aims and methods of a systematic
review and meta-analysis of studies reporting the behavioural effects of methylphenidate (MPH), the most commonly prescribed treatment for ADHD, in the SHR.
METHODS: Studies will be identified through a literature search using three different electronic databases: Medline, Embase and Web of Science. There will be no language restrictions. All s tudies that administered MPH to SHR and evaluated locomotion, attention, impulsivity or memory will be included.
UNASSIGNED: Studies will be prescreened based on title and abstract, and a full-text
review will be performed if necessary. Screening will be performed by two authors, and any disagreement will be discussed with a third author.
UNASSIGNED: Data extraction will be performed by two independent authors according to a standardised form. Studies will be grouped according to the behavioural outcomes reported, and a meta-analysis will be performed for each group. The influence of predefined covariates on the effects of MPH will be evaluated using meta-regression and sensitivity analyses. Data will be reported following PRISMA guidelines.