在许多技术中广泛使用稀土元素(REEs),但妊娠早期暴露于REE与妊娠期糖尿病(GDM)之间的关联尚不清楚.
这项巢式病例对照研究涉及200名GDM孕妇和200名来自通州北京大学出生队列的健康孕妇。我们检查了妊娠早期14种REE的血清浓度,并分析了它们与GDM风险的关系。
当在逻辑回归模型中单独考虑元素时,在REE和GDM之间没有发现显著的关联,调整混杂变量后(P>0.05)。在加权分位数和(WQS)回归中,REEs混合指数每降低1/4,导致GDM风险增加1.67倍(95%CI:1.12~2.49).钕(Nd),镨(Pr),镧(La)是混合物中最重要的贡献者。
研究结果表明,妊娠早期暴露于较低水平的REE混合物与GDM的风险增加有关。Nd,Pr,和La在混合物中表现出最强的效果。
The extensive use of rare earth elements (REEs) in many technologies was found to have effects on human health, but the association between early pregnancy exposure to REEs and gestational diabetes mellitus (GDM) is still unknown.
This nested case-control
study involved 200 pregnant women with GDM and 200 healthy pregnant women from the Peking University Birth Cohort in Tongzhou. We examined the serum concentrations of 14 REEs during early pregnancy and analyzed their associations with the risk of GDM.
When the elements were considered individually in the logistic regression model, no significant associations were found between REEs and GDM, after adjusting for confounding variables (P > 0.05). In weighted quantile sum (WQS) regression, each quartile decrease in the mixture index for REEs resulted in a 1.67-fold (95% CI: 1.12-2.49) increased risk of GDM. Neodymium (Nd), Praseodymium (Pr), and Lanthanum (La) were the most important contributors in the mixture.
The
study findings indicated that early pregnancy exposure to lower levels of REE mixture was associated with an increased risk of GDM, and Nd, Pr, and La exhibited the strongest effects in the mixture.