背景:结节病是一种可影响多个器官的全身性疾病。虽然最常见的是肺结节病,肾结节病的发生频率较低。我们在此报告一例结节病,其分布异常罕见,包括肾脏病变。
方法:一名51岁的日本女性因双侧腮腺肿胀和肾功能不全而转诊。计算机断层扫描显示双侧肾脏肿胀,腮腺,还有子宫.Ga闪烁显像在这些器官中也显示出明显的积累。对腮腺和子宫进行肾活检和细胞学评估,并诊断为这些器官的结节病。用泼尼松龙40mg/天开始治疗,然后肾功能障碍随后得到改善。此外,腮腺和子宫肿胀得到改善,各脏器Ga积聚消失。
结论:这是第一例合并腮腺和子宫病变的肾结节病。在Ga闪烁显像中观察到的病理学发现和反应性表明这些器官中存在病变。
BACKGROUND: Sarcoidosis is a systemic disease that can affect multiple organs. While pulmonary sarcoidosis is most commonly observed, renal sarcoidosis occurs less frequently. We herein report a
case of sarcoidosis with an exceptionally rare distribution including renal lesions.
METHODS: A 51-year-old Japanese female was referred because of bilateral parotid swelling and renal dysfunction. Computed tomography scan showed the swelling of bilateral kidneys, parotid glands, and uterus. Ga scintigraphy also showed remarkable accumulation in these organs. Renal biopsy and cytological evaluations of parotid gland and uterus were performed and she was diagnosed as sarcoidosis of these organs. Treatment was initiated with prednisolone 40 mg/day and then renal dysfunction subsequently improved. In addition, the swelling of parotid glands and uterus improved and Ga accumulation in each organ had disappeared.
CONCLUSIONS: This is a first
case of renal sarcoidosis complicated by parotid glands and uterus lesions. Pathological findings and the reactivity observed in Ga scintigraphy indicated the presence of lesions in these organs.