{Reference Type}: Case Reports
{Title}: A Rare Case of Abnormal Diffuse Brain Uptake on an 123I MIBG Scan in a Patient With High-Risk Neuroblastoma.
{Author}: Basavalingu D;Sadic M;Cheeney S;Parisi MT;
{Journal}: Clin Nucl Med
{Volume}: 49
{Issue}: 5
{Year}: 2024 May 1
{Factor}: 10.782
{DOI}: 10.1097/RLU.0000000000005179
{Abstract}: <B>UNASSIGNED: </B>123I-meta-iodobenzylguanidine (123I-MIBG) is extensively used for initial staging and response evaluation in children with neuroblastoma. Physiological uptake of 123I-MIBG occurs in the salivary glands, liver, adrenal gland, myocardium, bowel, and thyroid gland. 123I-MIBG cannot cross an intact blood-brain barrier. We present the rare case of a 3-year-old boy with neuroblastoma and meningeal metastases who underwent an 123I-MIBG scan for disease restaging that showed abnormal brain uptake. Abnormal MIBG uptake in the brain can occur if there is disruption of the blood-brain barrier either secondary to metastases or after damage to blood-brain barrier.