生物制药允许控制以前无法治愈的疾病。然而,它们的低溶解度和稳定性仍然阻碍它们的应用,运输,和存储。因此,研究人员已经应用了不同的化合物来保存和增强生物药物的输送,如离子液体(IL)和低共熔溶剂(DES)。尽管生物制药行业可以采用各种物质来增强配方,它们的作用将根据目标生物分子的性质和环境条件而改变。因此,这篇综述组织了当前关于应用IL和DES稳定生物制药的最新技术,考虑到生物分子的性质,ILs,和DES类,浓度范围,稳定的类型,和效果。我们还提供了关于IL和DES在药物制剂中的潜在利用的关键讨论,考虑到这一领域的限制,以及这些物质用于医疗应用的优点和缺点。总的来说,用于稳定生物制药的最常用的IL和DES类别是胆碱,咪唑啉-,以铵为基础,还采用了胆碱来改善其输送。有趣的是,稀释和浓缩的IL和DES溶液在生物药物的稳定性方面表现出相似的结果。通过额外的调查,IL和DES具有克服生物药物制剂中当前挑战的潜力。
Biopharmaceuticals have allowed the control of previously untreatable diseases. However, their low solubility and stability still hinder their application, transport, and storage. Hence, researchers have applied different compounds to preserve and enhance the delivery of biopharmaceuticals, such as ionic liquids (ILs) and deep eutectic solvents (DESs). Although the biopharmaceutical industry can employ various substances for enhancing formulations, their effect will change depending on the properties of the target biomolecule and environmental conditions. Hence, this
review organized the current state-of-the-art on the application of ILs and DESs to stabilize biopharmaceuticals, considering the properties of the biomolecules, ILs, and DESs classes, concentration range, types of stability, and effect. We also provided a critical discussion regarding the potential utilization of ILs and DESs in pharmaceutical formulations, considering the restrictions in this field, as well as the advantages and drawbacks of these substances for medical applications. Overall, the most applied IL and DES classes for stabilizing biopharmaceuticals were cholinium-, imidazolium-, and ammonium-based, with cholinium ILs also employed to improve their delivery. Interestingly, dilute and concentrated ILs and DESs solutions presented similar results regarding the stabilization of biopharmaceuticals. With additional investigation, ILs and DESs have the potential to overcome current challenges in biopharmaceutical formulation.