■各种遗传特征导致静脉血栓栓塞(VTE)的总体风险。此外,东亚VTE人群血栓形成的流行病学尚不清楚;因此,我们的目的是通过荟萃分析评估遗传性易栓症的比例.
■PubMed的出版物,EMBASE,科学网,和Cochrane在2022年12月30日之前进行了搜索。来自日本的研究,韩国,中国,香港,台湾,新加坡,泰国,越南,缅甸,柬埔寨也包括在内。先天性易栓症被描述为包括蛋白C(PC)缺乏症的疾病,蛋白质S(PS)缺乏症,抗凝血酶(AT)缺乏症,因子(F)V莱顿(FVL),和凝血酶原G20210A突变。由2名评审员选择研究进行方法学质量分析。随机效应模型用于荟萃分析,假设不同研究中的估计效果不相同。
■44项研究纳入了来自7个县/地区的6453名患者的荟萃分析。PC的普及,PS,AT缺陷为7.1%,8.3%,和3.8%,分别。在22项研究的2924名患者中,5例患者为FVL突变携带者。在10项研究的2196名患者中,在泰国的一项研究中,2例患者是凝血酶原G20210A突变的携带者。
■PC的普及,PS,AT缺陷相对较高,在东亚VTE患者中发现FVL和凝血酶原G20210A突变的患病率低得多。我们的数据强调PC的患病率相对较高,PS,东亚VTE人群的血栓形成和AT缺乏。
UNASSIGNED: Various inherited traits contribute to the overall risk of venous thromboembolism (VTE). In addition, the epidemiology of thrombophilia in the East-Asian VTE population remains unclear; thus, we aimed to assess the proportion of hereditary thrombophilia via a meta-analysis.
UNASSIGNED: Publications from PubMed, EMBASE, web of science, and Cochrane before December 30, 2022, were searched. Studies from Japan, Korea, China, Hong Kong, Taiwan, Singapore, Thailand, Vietnam, Myanmar, and Cambodia were included. Congenital thrombophilia was described as diseases including protein C (PC) deficiency, protein S (PS) deficiency, antithrombin (AT) deficiency, factor (F)V Leiden (FVL), and prothrombin G20210A mutations. Studies were selected by 2 reviewers for methodological quality analysis. A random-effects model was used for the meta-analysis, assuming that estimated effects in the different studies are not identical.
UNASSIGNED: Forty-four studies involving 6453 patients from 7 counties/regions were included in the meta-analysis. The prevalence of PC, PS, and AT deficiencies were 7.1%, 8.3%, and 3.8%, respectively. Among 2924 patients from 22 studies, 5 patients were carriers of FVL mutation. Among 2196 patients from 10 studies, 2 patients were carriers of prothrombin G20210A mutation in a Thailand study.
UNASSIGNED: The prevalence of PC, PS, and AT deficiencies was relatively high, while a much lower prevalence of FVL and prothrombin G20210A mutations were identified in East-Asian patients with VTE. Our data stress the relative higher prevalence of PC, PS, and AT deficiencies for thrombophilia in the East-Asian VTE population.