PDF(Pubmed)
Abstract：
Coumarin derivatives are the most used class of oral anticoagulants, and almost 1-2% of adults worldwide take it in the form of warfarin (WA) or acenocoumarol (AC). Cutaneous necrosis is a rare and severe complication of oral anticoagulant therapy. Most commonly, it occurs in the first 10 days, and the incidence peaks between the third and sixth day of starting treatment. Cutaneous necrosis due to AC therapy is underreported in the literature, and studies refer to this condition as \"coumarin-induced skin necrosis\"; however, this term is not totally accurate, as coumarin itself has no anticoagulant properties. We report a case of a 78-year-old female patient with AC-induced skin necrosis, who presented with cutaneous ecchymosis purpura over her face, arms, and lower extremities 3 hours after AC intake.
摘要：
香豆素衍生物是最常用的一类口服抗凝剂，全球近1-2％的成年人以华法林（WA）或acenocoumarol（AC）的形式服用。皮肤坏死是口服抗凝治疗的罕见且严重的并发症。最常见的是,它发生在前10天，开始治疗的第3天和第6天之间的发病率达到峰值。由于AC治疗引起的皮肤坏死在文献中报道不足，研究将这种情况称为“香豆素引起的皮肤坏死”；然而，这个词并不完全准确，因为香豆素本身没有抗凝血特性。我们报告了一例78岁的女性患者，患有AC引起的皮肤坏死，她脸上出现皮肤瘀斑紫癜，武器,和下肢3小时后AC摄入。
