Prosthodontics

口腔修复
  • 文章类型: Journal Article
    牙髓治疗牙齿的修复(ETT)仍然是现代牙科的重大挑战。由于牙髓手术的原始病理学和侵入性,这些牙齿通常会遭受严重的结构损伤。因此,与活牙相比,ETT更容易骨折,需要恢复性策略,可以有效地恢复功能和美学,同时最大程度地减少失败的风险。近年来,粘合剂牙科的进步和高强度陶瓷的发展进一步扩大了ETT的修复选择。由于结合修复体保留了更多的牙齿结构并增强了牙齿修复体的整体强度,因此受到了欢迎。修复材料和技术的选择受多种因素的影响,包括剩余牙齿结构的数量,牙齿的功能要求,和病人的审美要求。尽管有大量可用的材料和技术,恢复ETT的最佳方法仍然是一个正在进行的研究和辩论的话题。在这次全面审查中,探讨了修复经牙髓治疗的受损牙齿的现状和最新进展。存在许多治疗选择,涉及广泛的材料。本文旨在介绍过去十年的生物材料进展及其应用,提供治疗受损ETT的替代方法,目的是延长其在牙弓上的保留时间,并为每天面临此问题的牙科医生提供宝贵的资源。
    The restoration of endodontically treated teeth (ETT) remains a significant challenge in modern dentistry. These teeth often suffer from substantial structural damage due to both the original pathology and the invasive nature of endodontic procedures. Consequently, ETT are more susceptible to fractures compared to vital teeth, necessitating restorative strategies that can effectively restore both function and aesthetics while minimizing the risk of failure. In recent years, advances in adhesive dentistry and the development of high-strength ceramics have further expanded the restorative options for ETT. Bonded restorations have gained popularity as they preserve more tooth structure and enhance the overall strenght of the tooth-restoration complex. The choice of restorative material and technique is influenced by numerous factors, including the amount of remaining tooth structure, the functional requirements of the tooth, and the aesthetic demands of the patient. Despite the plethora of available materials and techniques, the optimal approach to restoring ETT remains a topic of ongoing research and debate. In this comprehensive review, the current state of and recent advances in restoring damaged endodontically treated teeth are explored. Numerous therapeutic options exist, involving a wide range of materials. This article aims to present the biomaterial advancements of the past decade and their applications, offering alternative approaches to treating damaged ETT with the goal of prolonging their retention on the dental arch and serving as a valuable resource for dental practitioners who face this issue daily.
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  • 文章类型: Journal Article
    激光,受激辐射光放大的首字母缩写,是现代牙科中具有多种应用的强大工具。它发出单色,光子诱导的连锁反应产生的相干光。可用的牙科激光器包括二极管,氩气,呃,Cr:YSGG,呃:YAG,Nd:YAG,和CO2。这些激光器的独特特性,允许它们根据操作参数有效地用于软组织和硬组织,将它们定位为特别适合广泛的牙科手术。与传统方法相比,激光具有改善止血和更快的伤口愈合等优点。这些益处强调了在牙科治疗中向激光技术的转变。在牙科修复领域,专注于美学,功能,以及假牙的生理方面,激光提供有希望的结果。在假肢选择中,固定局部义齿因其模仿自然牙齿的能力而脱颖而出,提供美学和功能特征,如果管理得当,会导致令人满意的长期结果。这篇综述论文探讨了激光技术在涉及固定局部义齿的假肢康复中的具体应用。通过调查口腔内激光手术,它有助于了解激光在提高患者满意度和临床效率方面的作用。
    Laser, an acronym for Light Amplification by Stimulated Emission of Radiation, is a powerful tool with diverse applications in modern dentistry. It emits monochromatic, coherent light resulting from photon-induced chain reactions. Available dental lasers include diode, argon, Er,Cr:YSGG, Er:YAG, Nd:YAG, and CO2. The unique property of these lasers, allowing them to be effectively used on both soft and hard tissues based on the operational parameters, positions them as particularly suited for a wide range of dental procedures. Compared to traditional methods, lasers offer advantages such as improved hemostasis and quicker wound healing. Such benefits stress the shift towards laser technology in dental treatment. In the realm of dental prosthodontics, which focuses on esthetics, functionality, and the physiological aspects of dental prostheses, lasers provide promising outcomes. Among the prosthetic options, fixed partial dentures stand out for their ability to mimic natural teeth, offering both esthetic and functional features, leading to satisfactory long-term outcomes if managed properly. This review paper delves into the specific application of laser technology in the context of prosthetic rehabilitation involving fixed partial dentures. By investigating intraoral laser procedures, it contributes to understanding laser\'s role in improving patients\' satisfaction and clinical efficiency in this field.
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  • 文章类型: Journal Article
    目的:回顾口腔内扫描仪(IOS)技术在种植修复中的应用,强调它们对数字印象准确性的影响,咬合注册,以及植入物支持的修复体的配合。
    方法:与种植修复相关的已发表的文章,数字印象的准确性,咬合注册,以及植入物支撑的固定修复体的配合。
    方法:选择了三个搜索引擎:Medline/PubMed,EBSCO,还有Cochrane.还进行了手动搜索。
    方法:文献检索筛选了相关数据库和期刊,以研究从2018年12月至2023年12月在数字种植体修复工作流程中的IOS应用。纳入标准包括随机对照试验,临床试验,案例系列,体外研究集中在IOS在数字种植修复中的应用。
    结论:数字牙科技术利用的增加导致数字种植修复工作流程显著融入临床医生的临床实践。几个变量会影响IOS生成的数字印象的准确性。一般来说,学术论文中的普遍观点是,数字工作流程适用于解决短跨度植入物支持的修复。然而,当涉及到大跨度缺陷时,数字工作流程的准确性仍然是一个有争议的问题。数字咬合注册是工作流程的组成部分。它主要取决于缺陷的大小和位置,扫描策略,解剖牙齿的变化,过度咬伤和其他因素。数字预制植入物修复体的整体配合包括近端,咬合接触以及修复体与植入物连接的准确性。研究方法需要标准化以进一步验证。
    结论:在临床实践中,必须对可能影响数字印象准确性和最终假体在种植修复中的适合性的各种因素进行全面和最新的理解。
    To review the developments in intraoral scanner (IOS) technologies applied in implant prosthodontics, emphasizing their influence on the accuracy of digital impressions, occlusal registrations, and the fit of implant-supported restorations.
    A collection of published articles related to implant prosthodontics, the accuracy of digital impressions, occlusal registration, and the fit of implant-supported fixed restorations.
    Three search engines were selected: Medline/PubMed, EBSCO, and Cochrane. A manual search was also conducted.
    A literature search screened relevant databases and journals for studies on IOS applications in digital implant prosthodontic workflows from Dec 2018 to Dec 2023. Inclusion criteria encompassed randomized control trials, clinical trials, case series, and in vitro research focused on the use of IOS in digital implant prosthodontics.
    The increased utilization of digital dental technologies has led to significant integration of digital implant prosthodontic workflows into clinicians\' clinical practice. Several variables affect the accuracy of digital impressions generated by IOS. Generally, the prevailing opinion in academic papers is that digital workflows are suitable for addressing short-span implant-supported restorations. However, when it comes to long-span defects, the accuracy of digital workflows is still a matter of debate. Digital bite registration is an integral part of the workflow. It depends mainly on the defect size and location, scan strategy, anatomical tooth variations, overbite and other factors. The overall fit of digitally prefabricated implant restorations comprises of proximal, occlusal contacts and how accurately the restoration connects with implants. Research methodologies need standardization for further validation.
    In clinical practice, it is essential to have a thorough and up-to-date comprehension of various factors that can affect the accuracy of digital impressions and the fit of the final prosthesis in implant prosthodontics.
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  • 文章类型: Journal Article
    垂直尺寸(VD)是口腔修复的关键因素,在牙科治疗的功能和美学结果中起着关键作用。这篇文献综述探讨了VD的理论基础和各个方面,包括它的定义,测量,及其在口腔修复中的临床意义。检查了VD与颞下颌关节紊乱病(TMDs)之间的关系。此外,VD对面部比例和美学的影响是显著的,因为它会影响面部的下三分之一,并影响患者的整体外观和自尊。总之,理解VD之间的复杂关系,TMD,面部美学,心理健康对于有效的口腔修复治疗至关重要。这篇全面的综述为VD在增强功能和美学结果方面的多方面作用提供了宝贵的见解,最终提高患者满意度和生活质量。
    Vertical dimension (VD) is a critical factor in prosthodontics, playing a pivotal role in the functional and aesthetic outcomes of dental treatments. This literature review explores theoretical foundations and the various aspects of VD, including its definition, measurement, and clinical significance in prosthodontics. The relationship between VD and temporomandibular disorders (TMDs) is examined. Additionally, the impact of VD on facial proportions and aesthetics is significant, as it affects the lower third of the face and influences the patient\'s overall appearance and self-esteem. In conclusion, understanding the intricate relationship between VD, TMDs, facial aesthetics, and psychological well-being is essential for effective prosthodontic treatment. This comprehensive review provides valuable insights into the multifaceted role of VD in enhancing both functional and aesthetic outcomes, ultimately improving patient satisfaction and quality of life.
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  • 文章类型: Journal Article
    修复是牙科亚专业,包括为缺失或受损的牙齿准备牙科修复。它越来越多地使用计算机辅助技术来计划和准备假牙。这项研究旨在通过对口腔修复中人工智能(AI)出版物的系统回顾来提出发现,以确定当前的趋势和未来的机会。评论问题是“人工智能在口腔修复学中的应用是什么,它们在口腔修复学中的表现如何?”在WebofScience中进行电子搜索,ScienceDirect,PubMed,并进行了Cochrane图书馆。搜索仅限于2012年1月至2024年1月的全文。Quadas-2用于评估选定研究的质量和潜在偏倚风险。在最初的搜索中总共确定了1925项研究。删除重复项并应用排除标准后,本综述共选择了30项研究.纳入研究的Quadas-2评估结果发现,共有18.3%的研究被确定为低偏倚风险研究,52.6%和28.9%的纳入研究被确定为偏倚风险较高且不明确的研究,分别。虽然还在发展,人工智能模型已经在牙科制图领域显示出希望,牙齿阴影的选择,自动恢复设计,绘制准备终点线,制造铸造优化,预测佩戴可移动假体的患者的面部变化,并设计可移动局部假牙。
    Prosthodontics is a dental subspecialty that includes the preparation of dental prosthetics for missing or damaged teeth. It increasingly uses computer-assisted technologies for planning and preparing dental prosthetics. This study aims to present the findings from a systematic review of publications on artificial intelligence (AI) in prosthodontics to identify current trends and future opportunities. The review question was \"What are the applications of AI in prosthodontics and how good is their performance in prosthodontics?\" Electronic searching in the Web of Science, ScienceDirect, PubMed, and Cochrane Library was conducted. The search was limited to full text from January 2012 to January 2024. Quadas-2 was used for assessing quality and potential risk of bias for the selected studies. A total of 1925 studies were identified in the initial search. After removing the duplicates and applying exclusion criteria, a total of 30 studies were selected for this review. Results of the Quadas-2 assessment of included studies found that a total of 18.3% of studies were identified as low risk of bias studies, whereas 52.6% and 28.9% of included studies were identified as studies with high and unclear risk of bias, respectively. Although they are still developing, AI models have already shown promise in the areas of dental charting, tooth shade selection, automated restoration design, mapping the preparation finishing line, manufacturing casting optimization, predicting facial changes in patients wearing removable prostheses, and designing removable partial dentures.
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  • 文章类型: Journal Article
    目的:立体光刻手术指南和数字化工作流程的兴起,结合更好的材料和装载原理知识,在植入时能够放置临时假体。此范围审查旨在评估可堆叠指南中可用的当前知识。
    方法:该综述集中于完全无牙或需要完全无牙的患者。研究的程序是为无牙患者使用可堆叠的指南,以便立即放置临时假体。临床终点是在手术后立即放置临时假体,并使用可堆叠的指南进行先前的骨复位。
    结果:12例病例报告或病例系列文章符合纳入标准,这不允许通过系统审查进行分析。纳入的研究为病例报告或病例系列。大多数物品显示出由3或4个骨针稳定的基底,锚定在颊部或舌部。关于骨减少的准确性(范围从0.0248mm至1.98mm)和植入物的放置与计划相比,只有4篇文章报告了定量数据。11篇文章显示植入物放置后过渡假体立即加载。
    结论:目前还没有关于该技术效率的前瞻性或比较研究。以一种可靠的方式,可堆叠的导向器似乎能够引导医生从皮瓣升高到临时螺钉固定的植入物支撑假体的放置。鉴于缺乏在引导手术这一特定领域的研究,需要进一步的研究来证实该技术的临床相关性.
    OBJECTIVE: The rise of stereolithographic surgical guides and digital workflow, combined with a better knowledge of materials and loading principle, has enabled the placement of the temporary prosthesis at the time of implant placement. This scoping review aimed to assess the current knowledge available on stackable guides.
    METHODS: The review focused on fully edentulous or requiring total edentulism patients. The procedure studied was the use of stackable guides for edentulous patients in order to place immediate temporary prostheses. The clinical endpoint was immediate placement of the provisional prosthesis after surgery combined with a prior bone reduction using a stackable guide.
    RESULTS: 12 case reports or case series articles met inclusion criteria, which did not allow an analysis by a systematic review. The included studies were case reports or case series. Most of the articles showed a base stabilized by 3 or 4 bone-pins, anchored in buccal or lingual part. Regarding the accuracy of bone reduction (ranged from 0.0248 mm to 1.98 mm) and implant placement when compared to planned, only 4 articles reported quantitative data. 11 articles showed an immediate loading with the transitional prosthesis after implant placement.
    CONCLUSIONS: There are as yet no prospective or comparative studies on the efficiency of this technique. In a reliable way, stackable guides seem to be able to guide the practitioner from the flap elevation to the placement of the temporary screw-retained implant supported prosthesis. Given the lack of studies in this specific field of guided surgery, further studies are needed to confirm the clinical relevance of this technique.
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  • 文章类型: Journal Article
    本研究的主要目的是对现有文献进行全面回顾,讨论关于后修复和核心修复的研究,涵盖其组成等方面,制造方法,和临床有效性。本审查采用的方法包括实施定义明确的搜索策略,制定纳入和排除标准,并选择相关研究来总结他们的发现。为了收集1993年至2023年之间发表的相关文献,研究小组在PubMed上进行了单独的搜索。WebofScience,和Embase数据库。总的来说,最初从这些电子数据库中检索了168个标题。通过应用预定义的排除标准,研究人员确定了73篇文章,专门针对在桩和岩心修复中采用的常规和计算机辅助设计/计算机辅助制造(CAD/CAM)技术。这些治疗通常用于恢复已经接受牙髓治疗并随后经历牙齿结构损失的牙齿。用于创建定制职位和核心的计算机技术的发展已成为传统方法的直接有效替代方法。这篇综述综合了论文,讨论了基于CAD/CAM的桩和芯构造所涉及的技术和材料。它探索了修复牙髓治疗牙齿的策略,强调直接和间接的方法。通常提到的材料包括氧化锆,复合树脂,和混合陶瓷。尽管关于CAD/CAM岗位和核心程序的文献有限,该综述强调了进一步研究以评估长期结局和疗效的必要性.此外,它建议包括对未来研究的影响和临床建议,以提高审查的深度和实践相关性。
    The primary objective of this study is to conduct a comprehensive review of the existing literature that discusses research on post and core restorations, covering aspects such as their composition, manufacturing methods, and clinical effectiveness. The methodology employed in this review encompasses the implementation of a well-defined search strategy, the establishment of criteria for inclusion and exclusion, and the selection of relevant studies to summarize their findings. To gather relevant literature published between 1993 and 2023, the research team conducted separate searches on PubMed, Web of Science, and Embase databases. In total, 168 titles were initially retrieved from these electronic databases. By applying the predefined exclusion criteria, the researchers identified 73 articles that specifically address the conventional and computer-aided design/computer-aided manufacturing (CAD/CAM) technologies employed in post and core restorations. These treatments are commonly employed to restore teeth that have received endodontic therapy and subsequently experienced loss of dental structure. The development of computerized technology for the creation of customized posts and cores has emerged as a straightforward and efficient alternative to traditional methods. The review synthesizes papers discussing the techniques and materials involved in CAD/CAM-based construction of post and cores. It explores strategies for restoring endodontically treated teeth, highlighting both direct and indirect approaches. Commonly mentioned materials include zirconia, composite resin, and hybrid ceramics. Despite the limited literature on CAD/CAM post and core procedures, the review emphasizes the necessity of further research to assess long-term outcomes and efficacy. Additionally, it suggests including implications for future research and clinical recommendations to enhance the depth and practical relevance of the review.
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  • 文章类型: Journal Article
    目的:本系统综述和荟萃分析的目的是评估准确性(真实性和精密度),边际和内部适应,与减法制造技术相比,增材制造制造的氧化锆牙冠的余量质量。
    方法:该调查遵循PRISMA-ScR系统评价指南,并在Prospero数据库(n°CRD42023452927)注册。四个电子数据库,包括PubMed,Scopus,Embase,并进行了WebofScience和手动搜索,以查找直到2023年9月发表的相关研究。评估真实性和准确性的体外研究,边际和内部适应,包括印刷冠与碾磨冠相比的边缘质量。关于植入物上牙冠的研究,桥体,临时修复,层压板,或仅排除实验材料。
    结果:共有9项研究纳入描述性报告,7项研究纳入荟萃分析。对真实性(P<0.74,I2=90%)和边缘质量(P<0.61,I2=0%)的全局荟萃分析表明,印刷和研磨的氧化锆冠的均方根之间没有显着差异。亚组分析对打印系统有显著影响(P<0.01)。冠面积的荟萃分析表明,大多数地区没有显着差异,除了边缘(有利于铣削冠)和轴向(有利于印刷冠)区域。对于精度和适应性,两种方法均显示临床可接受水平.
    结论:增材制造技术生产的牙冠具有与减法制造相当的真实性和余量质量。这两种技术都证明了生产具有精密水平的牙冠的能力,内部差异,和边际配合在临床可接受的范围内。
    结论:s3D打印成为一种有前途且潜在适用的替代制造氧化锆冠的方法,因为它显示出与减法方法产生的修复体相当的真实性和边缘质量。
    The purpose of this systematic review and meta-analysis was to evaluate the accuracy (trueness and precision), marginal and internal adaptation, and margin quality of zirconia crowns made by additive manufacturing compared to subtractive manufacturing technology.
    The investigation adhered to the PRISMA-ScR guidelines for systematic reviews and was registered at the Prospero database (n°CRD42023452927). Four electronic databases, including PubMed, Scopus, Embase, and Web of Science and manual search was conducted to find relevant studies published until September 2023. In vitro studies that assessed the trueness and precision, marginal and internal adaptation, and margin quality of printed crowns compared to milled ones were included. Studies on crowns over implants, pontics, temporary restorations, laminates, or exclusively experimental materials were excluded.
    A total of 9 studies were included in the descriptive reporting and 7 for meta-analysis. The global meta-analysis of the trueness (P<0.74,I2=90 %) and the margin quality (P<0.61,I2=0 %) indicated no significant difference between the root mean square of printed and milled zirconia crowns. The subgroup analysis for the printing system showed a significant effect (P<0.01). The meta-analysis of the crown areas indicated no significant difference in most of the areas, except for the marginal (favoring milled crowns) and axial (favoring printed crowns) areas. For precision and adaptation, both methods showed a clinically acceptable level.
    Additive manufacturing technology produces crowns with trueness and margin quality comparable to subtractive manufacturing. Both techniques have demonstrated the ability to produce crowns with precision levels, internal discrepancy, and marginal fit within clinically acceptable limits.
    3D printing emerges as a promising and potentially applicable alternative method for manufacturing zirconia crowns, as it shows trueness and margin quality comparable to restorations produced by the subtractive method.
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  • 文章类型: Journal Article
    尽管植入物支撑假体的发展,仍有一些患者更适合采用树脂粘合固定假牙(RBFDP)等保守治疗.本研究的目的是分析全陶瓷RBFDP的现有研究。在这项研究中,WebofScience,MEDLINE/PubMed,Scopus,Embase,科克伦图书馆,谷歌学者数据库搜索了2010年至2020年期间用英语发表的文章。根据资格标准审查了总共14项研究。结果表明,使用带有一个桥台的悬臂设计比两个桥台具有优势。此外,有人建议用保持性辅助工具设计的制剂,比如近端盒子,凹槽,还有针孔,可以提高RBFDP的生存率。IPSe.maxZirCAD,In-Ceram氧化铝,和氧化锆CAD/CAM是最常用的框架材料。大多数研究使用空气磨损,盐碱化,或表面处理用氢氟酸。粘合剂树脂水泥是最常用的水泥类型。In-Ceram陶瓷的存活率(85.3%-94.8%)低于In-Ceram氧化锆和IPSe.maxZirCAD。脱粘,其次是框架断裂,是失败的主要原因。随访3-10年,全瓷RBFDP的存活率为76%~100%.尽管RBFDP作为保守治疗已显示出令人满意的成功,在各种RBFDP设计的临床成功率方面,需要长期随访和更高的临床研究样本量,才能获得更可靠的结果.
    Despite the development of implant-supported prostheses, there are still patients for whom conservative treatments such as resin-bonded fixed dental prostheses (RBFDPs) are more appropriate. This study\'s objective was to analyze the available research on full-ceramic RBFDPs. In this study, Web of Science, MEDLINE/PubMed, Scopus, Embase, Cochrane Library, and Google Scholar databases were searched for articles published in English between 2010 and 2020. A total of 14 studies were reviewed based on the eligibility criteria. The results showed that using a cantilever design with one abutment had an advantage over two abutments. Additionally, it was proposed that preparations designed with retentive aids, such as a proximal box, groove, and pinhole, could improve RBFDP survival rates. IPS e.max ZirCAD, In-Ceram alumina, and zirconia CAD/CAM were the most commonly used framework materials. Most studies used air abrasion, salinization, or hydrofluoric acid for surface treatment. Adhesive resin cements were the most frequently used type of cement. The survival rate of In-Ceram ceramics (85.3%-94.8%) was lower than that of In-Ceram zirconia and IPS e.max ZirCAD. Debonding, followed by framework fracture, was the leading cause of failure. Following 3-10 years follow-up, the survival percentage of all-ceramic RBFDPs ranged from 76% to 100%. Although RBFDPs have demonstrated satisfactory success as a conservative treatment, long-term follow-ups and higher sample sizes in clinical research are required to gain more reliable outcomes on the clinical success rate of various RBFDP designs.
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  • 文章类型: Journal Article
    壳聚糖,一种多功能的生物聚合物,由于具有突出的特性,在牙科种植学学科中获得了认可。这篇全面的综述探讨了壳聚糖在牙种植体中的潜力,专注于它的生物相容性,生物活性,以及已用于牙科种植治疗的各种基于壳聚糖的材料。该综述还强调了在牙科植入物中进行表面处理以增强骨整合和抑制细菌生物膜形成的重要性。此外,化学结构,属性,并描述了壳聚糖的来源,以及其不同的结构形式。壳聚糖的特点特别是颜色,分子量,粘度,讨论了脱乙酰度对其应用的影响。这篇综述为聚合壳聚糖在增强牙科植入物的成功和功能方面的有希望的利用提供了有价值的见解。这项研究强调了壳聚糖在口腔种植学中的潜在应用。壳聚糖具有各种有利的性质,包括粘膜粘附性,止血作用,生物相容性,生物降解性,生物活性,和抗菌和抗真菌活性,这增强了其在牙科种植中的用途。然而,它在生理pH下具有有限的水溶性,这有时会限制其生物学应用,但是这个问题可以通过使用改性壳聚糖或壳聚糖衍生物来克服,这也显示出令人鼓舞的结果。最近的研究表明,壳聚糖可能作为涂层钛基植入物的一种有前途的材料,改善骨整合与抗菌性能。
    Chitosan, a versatile biopolymer, has gained recognition in the discipline of dental implantology due to possessing salient properties. This comprehensive review explores the potential of chitosan in dental implants, focusing on its biocompatibility, bioactivity, and the various chitosan-based materials that have been utilized for dental implant therapy. The review also highlights the importance of surface treatment in dental implants to enhance osseointegration and inhibit bacterial biofilm formation. Additionally, the chemical structure, properties, and sources of chitosan are described, along with its different structural forms. The characteristics of chitosan particularly color, molecular weight, viscosity, and degree of deacetylation are discussed about their influence on its applications. This review provides valuable insights into the promising utilization of polymeric chitosan in enhancing the success and functionality of dental implants. This study highlights the potential applications of chitosan in oral implantology. Chitosan possesses various advantageous properties, including muco-adhesiveness, hemostatic action, biocompatibility, biodegradability, bioactivity, and antibacterial and antifungal activities, which enhance its uses in dental implantology. However, it has limited aqueous solubility at the physiological pH, which sometimes restricts its biological application, but this problem can be overcome by using modified chitosan or chitosan derivatives, which have also shown encouraging results. Recent research suggests that chitosan may act as a promising material for coating titanium-based implants, improving osteointegration together with antibacterial properties.
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