累积网络荟萃分析(NMA)是一种通过实时更新向证据用户提供多种治疗的全局比较的方法。一些研究调查了累积NMA的排名和实践指南的建议。然而,据我们所知,尚无研究评估累积NMA排名和处方模式.这里,我们提出了一项元流行病学调查方案,将累积NMA的结果与绝经后骨质疏松症实践指南中的建议和实际处方进行比较.
我们将使用内分泌学会即将发布的绝经后骨质疏松症临床实践指南中的主要试验数据。我们将使用所有符合条件的试验进行累积NMA,并通过使用累积排名曲线下的表面生成治疗排名的层次结构。我们将在相关的社会网站搜索实践指南。两位综述作者将提取实践建议。我们会使用医疗开支小组调查的数据,非制度化人口的美国代表性样本,来确定处方模式。
因为所有数据都将从公共数据库中检索,不需要机构审查委员会的批准。我们将在同行评审的期刊上发表我们的发现,并在会议上介绍关键发现。
UMIN000031894:预结果。
Cumulative network meta-analysis (NMA) is a method to provide a global comparison of multiple treatments with real-time update to evidence users. Several studies investigated the ranking of cumulative NMA and the recommendations of practice
guidelines. However, to the best of our knowledge, no study has evaluated the cumulative NMA ranking and prescription patterns. Here, we present a protocol for a meta-epidemiological investigation to compare the results of cumulative NMA with the recommendations in postmenopausal osteoporosis practice
guidelines and with the actual prescriptions.
We will use the data of primary trials from the upcoming postmenopausal osteoporosis clinical practice
guideline of the Endocrine Society. We will conduct cumulative NMA using all eligible trials and generate hierarchy of treatment rankings by using the surface under the cumulative ranking curve. We will search practice
guidelines in relevant society websites. Two review authors will extract the practice recommendations. We will use data from the Medical Expenditures Panel Survey, a US representative sample of the non-institutionalised population, to determine the prescription patterns.
Because all data will be retrieved from public databases, institutional review board approval is not required. We will publish our findings in a peer-reviewed journal and present key findings at conferences.
UMIN000031894: Pre-results.