Primary prevention

初级预防
  • 文章类型: Journal Article
    目的:本研究的目的是应用和评估基于心理弹性护理模式和应对技能训练模式的预防虐待儿童计划在怀孕和产褥期未婚母亲中的应用和有效性。
    方法:本研究为前瞻性单病例,AB设计有四个重复的自我问卷措施和三个观察措施。通过从怀孕32至34周至分娩后6周的个人访问,为7名未婚母亲提供了10次预防虐待儿童计划。问卷组成与韧性有关,产妇压力,母性态度,亲子互动,虐待儿童的可能性。通过视频记录(共16次)喂养过程中亲子互动并由三名专家进行分析来测量观察结果。数据分析采用Wilcoxon符号秩检验和Friedman检验。
    结果:与干预前相比,干预后产妇态度和亲子互动在统计学上有显著改善。然而,与干预前相比,干预后产妇压力下降,但没有统计学意义。此外,复原力和虐待儿童的可能性没有统计学意义.该方案通过促进育儿态度和亲子互动,在防止虐待儿童方面部分有效。
    结论:本研究关注个体韧性,并应用系统干预作为应对技能训练,以防止虐待儿童。这项研究是有意义的,因为干预措施是通过个别访问未婚母亲在儿童虐待的高风险,程序被应用了,包括孕期和产后,尽早防止虐待儿童。
    OBJECTIVE: The purpose of this study is to apply and evaluate the effectiveness of a child abuse prevention program based on the Nursing Model of Resilience and Coping Skills Training Model for unmarried mothers during pregnancy and puerperium.
    METHODS: This study had a prospective single-case, AB design with four repeated self-questionnaire measures and three observational measures. Seven unmarried mothers were provided with 10 sessions child abuse prevention program through individual visits from 32 to 34 weeks of pregnancy to 6 weeks after childbirth. The questionnaire was composed related to resilience, maternal stress, maternal attitude, parent-child interaction, child abuse potential. The observation was measured by video recording (total 16 times) the interaction of parent-child during feeding and analyzing it by three experts. Data were analyzed by Wilcoxon signed-rank test and Friedman\'s test.
    RESULTS: Maternal attitude and parent-child interaction were statistically significantly improved after intervention compared to before intervention. However, maternal stress decreased after intervention compared to before intervention, but it was not statistically significant. Also, resilience and child abuse potential were not statistically significant. This program is partially effective in preventing child abuse by promoting parenting attitudes and parent-child interactions.
    CONCLUSIONS: This study focused on individual resilience and applied systematic intervention as coping skills training to prevent child abuse. This study is meaningful in that interventions were conducted through individual visits to unmarried mothers at high risk of child abuse, and the program was applied, including pregnancy and postpartum periods, to prevent child abuse early.
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  • 文章类型: Journal Article
    评估动脉粥样硬化性心血管疾病(ASCVD)的风险是临床医生的日常挑战,对于定制预防性医疗和指导共同决策至关重要。新的成像模式和新的生物标志物允许更准确地评估患者风险,并最大限度地减少过度或不充分治疗患者的风险。主要的心血管医学协会已在其指南中纳入了新的诊断方式,以帮助ASCVD的一级和二级预防的临床决策。本综述根据现有指南和专家意见,介绍了与评估和降低ASCVD风险相关的常见案例。
    Estimating the risk of atherosclerotic cardiovascular disease (ASCVD) is a daily challenge for clinicians and is crucial to tailoring preventive medical care and guiding shared decision-making. New imaging modalities and novel biomarkers allow for more accurate assessment of patient risk and minimize the risk of over- or undertreating patients. Major cardiovascular medicine societies have incorporated new diagnostic modalities in their guidelines to aid clinical decision-making for primary and secondary prevention of ASCVD. This review presents commonly encountered cases relevant to estimating and reducing ASCVD risk based on available guidelines and expert opinion.
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  • 文章类型: Journal Article
    目标:阐明实施旨在支持社区、尊重,西澳大利亚州一个地区城镇的平等(CRE)和家庭和家庭暴力(FDV)初级预防计划。
    方法:这项研究借鉴了文档和对LeadingLights成员的访谈,由当地组织合作产生的宣传小组,以传达CRE行动计划的目标和优先事项。访谈探讨了如何推广初级预防信息,以培养社区对解决FDV驱动因素的支持性态度。
    结果:该计划培养了一个学习社区,该社区协调了有关FDV驱动因素的公共信息,以保证组织遵守CRE价值观。随着时间的推移,消息传递的传播受到人员配置不一致的影响,资源和个人组织承诺的不连续性,以及对性别平等信息的担忧。
    结论:沟通策略提高了领先灯成员对FDV驱动因素的认识。反过来,该小组制作了媒体内容,使每个组织都致力于解决使FDV成为可能的态度和行为。
    结论:社区合作需要时间,资源,和协调,以可持续地促进支持暴力的社会规范的变化。
    OBJECTIVE: To illuminate the enablers and challenges of implementing a communication strategy designed to support Community, Respect, Equality (CRE) and a family and domestic violence (FDV) primary prevention plan in a regional Western Australian town.
    METHODS: This research draws on documentation and interviews with members of Leading Lights, an advocacy group arising from a collaboration of local organisations to communicate the goals and priorities of the CRE action plan. Interviews explored how primary prevention messages were promoted to foster supportive community attitudes toward addressing the drivers of FDV.
    RESULTS: The initiative fostered a learning community that coordinated public messaging about the drivers of FDV for organisations pledged to the CRE values. The diffusion of messaging was affected over time by inconsistent staffing, discontinuities in resourcing and individual organisational commitment, and concerns about gender equality messaging.
    CONCLUSIONS: The communications strategy increased awareness of the drivers of FDV among the members of the Leading Lights. In turn, this group produced media content that made visible each organisation\'s commitment to addressing the attitudes and behaviours that enable FDV.
    CONCLUSIONS: Community collaborations need time, resourcing, and coordination to sustainably prompt changes in social norms that underpin violence.
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  • 文章类型: Case Reports
    口服暴露前预防(PrEP)在预防人类免疫缺陷病毒(HIV)感染中非常有效,然而,大多数性活跃的青少年和年轻人(AYAs)感染艾滋病毒的风险最高,特别是与男性发生性关系的男性,没有开这种药。提供者对有风险的AYA患者处方PrEP的犹豫通常与患者不依从性及其对诱导HIV药物抵抗的影响的担忧有关。本病例报告有两个目的。首先,概述AYA患者的临床过程,该患者规定了3个月的PrEP,然后发现具有M184V抗性突变的HIV,随后开始接受HIV治疗。第二,通过提供有关PrEP药物耐药模式的临床数据,说明开始使用PrEP的益处如何大于其风险。患者最终在开始HIV治疗的5个月内实现了病毒抑制,该治疗已经持续了2年。这个案例说明了M184V抗性突变,虽然很少与PrEP相关,不太可能影响艾滋病毒治疗的选择。提供者应向有HIV感染风险的AYA患者推荐并开具口服PrEP,而不必担心不依从性会导致HIV药物抵抗。
    Oral pre-exposure prophylaxis (PrEP) in the prevention of human immunodeficiency virus (HIV) infection is highly effective, yet the majority of sexually active adolescents and young adults (AYAs) at highest risk for HIV infection, particularly AYA males who have sex with males, have not been prescribed this medication. Provider hesitancy in prescribing PrEP to at-risk AYA patients is often associated with concerns about patient nonadherence and its effect on inducing HIV medication resistance. This case report has two aims. First, to outline the clinical course for an AYA patient prescribed PrEP for 3 months and then found to have HIV with an M184V resistance mutation and subsequently started on HIV treatment. And second, to illustrate how the benefits of PrEP initiation outweigh its risks by presenting clinical data on resistance patterns to PrEP medications. The patient eventually achieved viral suppression within 5 months of starting HIV treatment which has been sustained up to 2 years. This case illustrates that M184V resistance mutations, although rarely associated with PrEP, are unlikely to impact options for HIV treatment. Providers should recommend and prescribe oral PrEP to AYA patients at risk for HIV infection without concern for nonadherence leading to HIV medication resistance.
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  • 文章类型: Review
    世界上每年有超过一百万人死亡,自杀是一个主要的公共卫生问题,可以通过有效的预防计划大大减少。电子卫生工具对初级预防特别感兴趣,因为它们可以解决广泛的人群,包括不知道自己风险的人,并提供信息和帮助,而不必担心污名化。我们的主要目标是通过定义IT特征的特征来定义法国普通人群中用于自杀一级预防的电子健康工具的总体特征;所提供信息的内容;结构的最佳方式;以及应该如何传递以及由谁传递。这项研究是通过文献综述和与利益相关者的共建阶段进行的。四种类型的策略可以指导自杀一级预防的电子健康工具的建设:教育和意识,(自我)筛选,获得支持,和心理健康应对。它们应该可以在不同的设备上访问,以覆盖大多数用户,语言和内容应适应目标人群和正在解决的问题。最后,该工具应符合道德和质量最佳实践。电子健康工具StopBlues是根据这些建议开发的。
    With over one million deaths per year in the world, suicide is a major public health problem that could be significantly reduced by effective prevention programs. E-health tools are of particular interest for primary prevention as they can address a broad population including people unaware of their own risk and provide information and help without the fear of stigma. Our main objective was to define the overall characteristics of an e-health tool for suicide primary prevention in the French general population by defining the characteristics of the IT features; the content of the information delivered; the best way to structure it; and how it should be relayed and by whom. The research was carried out through a literature review and a co-construction phase with stakeholders. Four types of strategies may guide the construction of e-health tools for suicide primary prevention: education and awareness, (self-)screening, accessing support, and mental health coping. They should be accessible on different devices to reach the most users, and language and content should be adapted to the target population and to the issue being addressed. Finally, the tool should be consistent with ethical and quality best practices. The e-health tool StopBlues was developed following those recommendations.
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  • 文章类型: Journal Article
    背景:在Aotearoa/新西兰(NZ)的一般实践诊断和管理糖尿病前期。这项工作很重要,因为它有可能延迟或预防2型糖尿病(T2DM)的发病。减少新西兰的健康不平等,以及T2DM对医疗保健服务的负担。然而,以前没有研究检查这项工作是如何在新西兰常规进行的。
    方法:两个为种族和社会经济不同人群服务的实践案例研究,其次是跨案例分析。
    结果:新西兰医疗保健环境,包括筹资机制,报告目标,疾病以护理为中心,共同采取行动,在一般实践中不激励和取消优先考虑糖尿病前期护理。健康的社会决定因素差异影响患者参与和应对糖尿病前期护理的能力,对这项工作产生重大影响。确定了关于糖尿病前期的重要性和系统筛查实践中的差距的不同观点。所使用的干预措施不一致,缺乏全面的持续支持。
    结论:复杂的多层因素对糖尿病前期护理的影响,许多障碍无法在一般实践层面解决。为同时患有糖尿病前期/T2DM的最弱势群体服务的实践受到所确定的障碍的不利影响更大。
    In Aotearoa/New Zealand (NZ) general practices diagnose and manage pre-diabetes. This work is important as it has the potential to delay or prevent the onset of Type 2 Diabetes (T2DM), reduce NZ\'s health inequities, and the burden that T2DM places on health care services. However, no study has previously examined how this work routinely occurs in NZ.
    Two case studies of practices serving ethnically and socio-economically diverse populations, followed by cross-case analysis.
    The NZ health care context including funding mechanisms, reporting targets, and the disease centred focus of care, acted together to dis-incentivise and de-prioritise pre-diabetes care in general practices. The social determinants of health differentially influenced patients\' ability to engage with and respond to pre-diabetes care, significantly impacting this work. Differing perspectives about the significance of pre-diabetes and gaps in systematic screening practices were identified. Interventions used were inconsistent and lacked comprehensive ongoing support.
    Complex multi-layered factors impact on pre-diabetes care, and many of the barriers cannot be addressed at the general practice level. The practice serving the most disadvantaged population who concurrently have higher rates of pre-diabetes/T2DM were more adversely affected by the barriers identified.
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  • 文章类型: Journal Article
    脊柱裂是一种影响中枢神经系统的严重出生缺陷,以神经管不完全闭合为特征。埃塞俄比亚的脊柱裂患病率很高,影响到每10,000名新生儿约40例。出生时脊柱裂的婴儿需要早期闭合手术,在出生后的前2-3天内完成。有些婴儿需要重复手术来解决并发症,包括脑积水.没有医疗,婴儿在生命的头5年内有很高的死亡风险。出生时脊柱裂闭合手术的神经外科能力在埃塞俄比亚是一个相对较新的发展。到达另一个基金会,一个基于OR的非营利组织,美国,2009年开始在埃塞俄比亚工作,并在培训神经外科医生和改善脊柱裂和脑积水的治疗方面发挥了重要作用。随着神经外科的发展,基金会已投资培训多学科团队进行患者善后护理,并启动了改善患者结局研究的平台.截至2022年,他们在全国范围内支持六个脊柱裂“卓越中心”,并通过在埃塞俄比亚强制强化主食,不断倡导脊柱裂的一级预防。本文描述了Reachother在埃塞俄比亚短时间内的努力,许多脊柱裂和无脑畸形患者和家庭受益。我们将其作为其他国家的案例研究记录,以模拟资源有限且脊柱裂和脑积水的患病率很高的情况。尤其是在亚洲和非洲。
    Spina bifida is a serious birth defect affecting the central nervous system, characterized by incomplete closure of the neural tube. Ethiopia has a very high prevalence of spina bifida, affecting about 40 cases per 10,000 births. Babies born with spina bifida require early closure surgery, done within the first 2-3 days after birth. Some babies need repeat surgeries to address complications, including hydrocephalus. Without medical care, babies have a high risk of death within the first 5 years of their life. Neurosurgical capacity for spina bifida closure surgery at birth is a relatively new development in Ethiopia. ReachAnother Foundation, a not-for-profit organization based in OR, USA, started work in Ethiopia in 2009 and has been instrumental in training neurosurgeons and improving treatment for spina bifida and hydrocephalus. Along with the development of neurosurgical care, the Foundation has invested in training multi-disciplinary teams to conduct patient aftercare and has launched a platform for improved patient outcomes research. As of year 2022, they support six spina bifida \"Centers of Excellence\" nationwide and are continuously advocating for primary prevention of spina bifida through mandatory fortification of staple foods in Ethiopia. This paper describes ReachAnother\'s efforts in Ethiopia in a short interval of time, benefiting numerous patients and families with spina bifida and anencephaly. We document this as a case study for other countries to model where resources are limited and the prevalence of spina bifida and hydrocephalus is high, especially in Asia and Africa.
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  • 文章类型: Case Reports
    未经证实:皮下植入式心脏复律除颤器(S-ICD)越来越多地用于无起搏指征的患者,并且可以减少静脉并发症,心内膜炎和拔牙发病率。皮下可植入的心脏复律除颤器移位可能不如经静脉的移位明显。
    未经证实:一名59岁的男子在研究中风后被发现患有与大量饮酒相关的扩张型心肌病。尽管戒烟和最佳药物治疗2年,他的射血分数仍然严重受损,他使用制造商推荐的筛查和植入方法获得了S-ICD,由经验丰富的操作员。十个月后,尽管进行了最佳编程,但仍提供了不适当的电击。在第二次不适当治疗的情况下,通过侧向胸部X线照相术证明了设备移位。在第一次入场时,没有进行横向电影,进行了简单的设备编程,但未能防止第二次发生。患者要求外植体;因为在开始使用sacutril/valsartan后心室功能得到改善,临床团队选择移除该装置。
    UNASSIGNED:需要仔细检查外侧胸膜并检查器械适应症,以减少不适当电击的风险。这是对发电机位移-引线位移后不适当装置活动的首次描述。
    UNASSIGNED: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are increasingly used in patients without a pacing indication, and may reduce venous complications, endocarditis and extraction morbidity. Subcutaneous implantable cardioverter-defibrillator displacements may be less obvious than their transvenous counterparts.
    UNASSIGNED: A 59-year-old man was found to have dilated cardiomyopathy associated with heavy alcohol intake following investigation for a stroke. Despite 2 years of alcohol cessation and optimal drug therapy, his ejection fraction remained severely impaired, and he received an S-ICD using the manufacturer recommended screening and implant method, and by an experienced operator. Ten months later, inappropriate shocks were delivered despite optimal programming. Device displacement was demonstrated by lateral chest radiography on the second instance of inappropriate therapy. On the first admission, a lateral film was not performed, and simple device programming was undertaken which failed to prevent the second occurrence. The patient requested an explant; as ventricular function had improved following initiation of sacubutril/valsartan, the clinical team opted to remove the device.
    UNASSIGNED: Careful inspection of lateral chest films and review of device indication are needed to reduce the risk of inappropriate shocks. This is the first description of inappropriate device activity following lone generator displacement-lead displacement is well described.
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  • 文章类型: Journal Article
    A组链球菌(GAS)感染可引发免疫介导的反应,导致急性风湿热(ARF)。社会和环境危险因素对GAS咽炎和皮肤感染的作用尚不清楚。本研究旨在确定与GAS咽炎和皮肤感染相关的因素,并确定这些是否与ARF相同。
    病例对照研究,包括733名5-14岁的儿童,于2018年3月至2019年10月在奥克兰进行,新西兰。健康对照(n=190)和有症状的病例,包括GAS咽炎(n=210),GAS血清阴性携带者(n=182),和GAS皮肤感染(n=151)被招募。训练有素的面试官管理全面,预先测试,面对面的问卷调查。
    多变量分析确定了获得初级医疗保健的障碍与患有GAS咽炎之间的强关联(调整后的OR3·3;95%CI1·8-6·0),GAS携带(aOR2·9;95%CI1·5-6·0)或GAS皮肤感染(aOR3·5;95%CI1·6-7·6)。患有GAS皮肤感染的儿童比所有其他人群更有可能报告生活在拥挤的家中(aOR1·9;95%CI1·0-3·4),有毛利人或太平洋祖父母(aOR3·0;95%CI1·2-7·6),ARF家族史(aOR2·2;95%CI1·1-4·3),或既往诊断为湿疹(aOR3·9;95%CI2·2-6·9)。
    减少获得初级医疗保健的障碍(包括财务限制,无法预约,缺乏运输,以及其他儿童缺乏托儿服务)来治疗GAS咽炎和皮肤感染可能会减少这些感染并减少后遗症,包括ARF。这些战略应共同设计,并在文化上适合所服务和仔细评估的社区。
    这项工作得到了新西兰健康研究委员会(HRC)的支持,奖励编号16/005。
    UNASSIGNED: Group A streptococcal (GAS) infections can trigger an immune-mediated response resulting in acute rheumatic fever (ARF). The role of social and environmental risk factors for GAS pharyngitis and skin infections are not well understood. This study aimed to identify factors associated with GAS pharyngitis and skin infections, and to determine if these are the same as those for ARF.
    UNASSIGNED: A case-control study, including 733 children aged 5-14 years, was undertaken between March 2018 and October 2019 in Auckland, New Zealand. Healthy controls (n = 190) and symptomatic cases including GAS pharyngitis (n = 210), GAS seronegative carriers (n = 182), and GAS skin infections (n = 151) were recruited. Trained interviewers administered a comprehensive, pre-tested, face-to-face questionnaire.
    UNASSIGNED: Multivariable analysis identified strong associations between barriers to accessing primary healthcare and having GAS pharyngitis (adjusted OR 3·3; 95% CI 1·8-6·0), GAS carriage (aOR 2·9; 95% CI 1·5-6·0) or a GAS skin infection (aOR 3·5; 95% CI 1·6-7·6). Children who had GAS skin infections were more likely than all other groups to report living in a crowded home (aOR 1·9; 95% CI 1·0-3·4), have Māori or Pacific grandparents (aOR 3·0; 95% CI 1·2-7·6), a family history of ARF (aOR 2·2; 95% CI 1·1-4·3), or having a previous diagnosis of eczema (aOR 3·9; 95% CI 2·2-6·9).
    UNASSIGNED: Reducing barriers to accessing primary healthcare (including financial restrictions, the inability to book an appointment, lack of transport, and lack of childcare for other children) to treat GAS pharyngitis and skin infections could potentially reduce these infections and lead to a reduction in their sequelae, including ARF. These strategies should be co-designed and culturally appropriate for the communities being served and carefully evaluated.
    UNASSIGNED: This work was supported by the Health Research Council of New Zealand (HRC), award number 16/005.
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  • 文章类型: Journal Article
    最近的指南建议已从建议在生命的头3年中长期避免使用过敏性食物转变为一级预防方法,包括有意早期引入有发生食物过敏风险的婴儿。尽管如此,一些婴儿,尤其是那些患有严重湿疹的人,他们患花生过敏的风险最高,由于犹豫和其他因素,未能获得早期花生引进的预防益处。引入后难以坚持定期摄入进一步降低了一级预防的有效性。正如新兴的现实世界证据表明,在婴儿中进行花生口服免疫疗法(OIT)是有效且安全的,花生OIT可能是花生过敏婴儿的治疗选择。这篇评论讨论了好处,风险,以及向一级预防策略失败的婴儿提供花生OIT的障碍。我们提出了一个新的概念,即在花生引入失败后,通过与家人的共同决策过程,尽快为花生过敏的婴儿提供花生OIT,在这种情况下,人们更倾向于主动管理,而不是回避。
    Recent guideline recommendations have shifted from recommending prolonged avoidance of allergenic foods in the first 3 years of life to a primary prevention approach involving the deliberate early introduction to infants at risk of developing food allergy. Despite this, some infants, especially those with severe eczema who are at highest risk for developing peanut allergy, fail to receive the preventative benefits of early peanut introduction due to hesitancy and other factors. Difficulty adhering to regular ingestion after introduction further reduces the effectiveness of primary prevention. As emerging real-world evidence has demonstrated that performing peanut oral immunotherapy (OIT) among infants is effective and safe, peanut OIT could be a treatment option for infants with peanut allergy. This review discusses the benefits, risks, and barriers to offering peanut OIT to infants who fail primary prevention strategies. We propose the novel concept that infants with peanut allergy be offered peanut OIT as soon as possible after failed peanut introduction through a shared decision-making process with the family, where there is a preference for active management rather than avoidance.
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