越来越多的证据强调肠道微生物群组成和各种神经系统疾病中的相对丰度存在显著变化。我们对广泛的神经系统疾病(阿尔茨海默病(AD),帕金森病(PD),多发性硬化症(MS),肌萎缩侧索硬化,和中风)。包括52项研究,代表5496名患者。在属一级,最常见的微生物群是Akkermansia,粪杆菌,还有Prevotella.MS和PD病理之间的重叠最强,共有八个属(阿克曼西亚,Butyricicocus,双歧杆菌,球菌,Dorea,粪杆菌,副杆菌属,和普雷沃氏菌)和PD和中风,共享六个属(肠球菌,粪杆菌,乳酸菌,副杆菌属,普雷沃氏菌,和Roseburia)。AD的识别签名重叠,PD,MS提出了一个问题,即这些疾病是否反映了这些疾病的共同病因或相当普遍的后果。AD的低数量和低功率阻碍了解释,ALS,和中风有充分的机会假阳性和假阴性结果。
There is a growing body of evidence highlighting there are significant changes in the gut microbiota composition and relative abundance in various neurological disorders. We performed a systematic
review of the different microbiota altered in a wide range of neurological disorders (Alzheimer\'s disease (AD), Parkinson\'s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis, and stroke). Fifty-two studies were included representing 5496 patients. At the genus level, the most frequently involved microbiota are Akkermansia, Faecalibacterium, and
Prevotella. The overlap between the pathologies was strongest for MS and PD, sharing eight genera (Akkermansia, Butyricicoccus, Bifidobacterium, Coprococcus, Dorea, Faecalibacterium, Parabacteroides, and
Prevotella) and PD and stroke, sharing six genera (Enterococcus, Faecalibacterium, Lactobacillus, Parabacteroides,
Prevotella, and Roseburia). The identification signatures overlapping for AD, PD, and MS raise the question of whether these reflect a common etiology or rather common consequence of these diseases. The interpretation is hampered by the low number and low power for AD, ALS, and stroke with ample opportunity for false positive and false negative findings.